Abstract: A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing polymer and a free amino group-containing drug which are ionically bonded to each other.
Type:
Grant
Filed:
January 26, 2000
Date of Patent:
March 15, 2005
Assignees:
Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S., Poly-Med, Incorporated
Inventors:
Shalaby Wahba Shalaby, Steven A. Jackson, Jacques-Pierre Moreau
Abstract: Disclosed is a sustained release pharmaceutical composition. The composition includes a polyester containing a free COOH group ionically conjugated with a bioactive polypeptide comprising at least one effective ionogenic amine, wherein at least 50% by weight of the polypeptide present in the composition is ionically conjugated to the polyester.
Type:
Grant
Filed:
January 26, 1999
Date of Patent:
April 24, 2001
Assignees:
Societe de Conseils de Recherches et d'Applications
Scientifiques, SAS, Poly-Med Incorporated
Inventors:
Shalaby Wahba Shalaby, Steven A. Jackson, Jacques-Pierre Moreau