Patents Assigned to Polychip Pharmaceuticals PTY LTD
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Publication number: 20120225811Abstract: A dicarba analogue of insulin comprising an A-chain and a B-chain or fragments, salts, solvates, derivatives, isomers or tautomers of the A-chain, the B-chain or both, provided that the dicarba analogue is not [A7,B7-(2,7-diaminosuberoyl]-des-(B26-B30)-insulin B25-amide.Type: ApplicationFiled: May 25, 2011Publication date: September 6, 2012Applicants: POLYCHIP PHARMACEUTICALS PTY LTD, MONASH UNIVERSITYInventors: Andrea Robinson, Bianca Van Lierop
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Publication number: 20120142892Abstract: According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides.Type: ApplicationFiled: February 16, 2012Publication date: June 7, 2012Applicants: POLYCHIP PHARMACEUTICALS PTY LTD., MONASH UNIVERSITYInventors: Andrea Robinson, Jomana Elaridi
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Patent number: 8188217Abstract: The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis.Type: GrantFiled: February 16, 2007Date of Patent: May 29, 2012Assignees: Monash University, Polychip Pharmaceuticals Pty Ltd.Inventors: Andrea Jane Robinson, William Roy Jackson, Jim Patel, Jomana Elaridi
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Patent number: 8124726Abstract: According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides.Type: GrantFiled: May 20, 2009Date of Patent: February 28, 2012Assignees: Monash University, Polychip Pharmaceuticals Pty Ltd.Inventors: Andrea Robinson, Jomana Elaridi
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Publication number: 20100191665Abstract: A service value calculation system includes: crisis problem inspection means which detects a crisis or a problem of a service object; and virtual damage amount calculation means which calculates a virtual damage amount generated if a detected crisis or problem is not solved when a service is not applied and calculates the service value.Type: ApplicationFiled: July 10, 2008Publication date: July 29, 2010Applicants: MONASH UNIVERSITY, POLYCHIP PHARMACEUTICALS PTY LTD,Inventors: Kyoji Hirata, Ken Hanazawa, Masahiro Iwadare
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Patent number: 7745573Abstract: According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides.Type: GrantFiled: June 30, 2006Date of Patent: June 29, 2010Assignees: Polychip Pharmaceuticals Pty Ltd., Monash UniversityInventors: Andrea Robinson, Jomana Elaridi
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Publication number: 20100036089Abstract: The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis.Type: ApplicationFiled: February 16, 2007Publication date: February 11, 2010Applicants: MONASH UNIVERSITY, POLYCHIP PHARMACEUTICALS PTY LTDInventors: Andrea Jane Robinson, William Roy Jackson, Jim Patel, Jomana Elaridi
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Publication number: 20100022749Abstract: According to the present invention, there is provided a range of new conotoxin derivatives and methods for synthesizing these analogues and other intramolecular dicarba bridge-containing peptides, including dicarba-disulfide bridge-containing peptides.Type: ApplicationFiled: May 20, 2009Publication date: January 28, 2010Applicants: MONASH UNIVERSITY, POLYCHIP PHARMACEUTICALS PTY LTD.Inventors: Andrea Robinson, Jomana Elaridi
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Patent number: 7538190Abstract: Described herein are methods for forming two or more dicarba bridges, as well as new compounds containing dicarba bridges.Type: GrantFiled: June 30, 2006Date of Patent: May 26, 2009Assignees: Polychip Pharmaceuticals Pty Ltd, Monash UniversityInventors: Andrea Robinson, Roy William Jackson, Jim Patel, Jomana Elaridi
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Patent number: 7176332Abstract: A method for the preparation of a compound of formula (VI): in which R2 is an optionally substituted C1–C6 alkyl; R4 is H, OH, an optionally substituted C1–C6 alkyl or an optionally substituted C1–C6 alkoxy; R5 is an optionally substituted aryl, an optionally substituted aralkyl, or an optionally substituted alkyl; and R6 is H or an optionally substituted C1–C6 alkyl; the method including the step of subjecting a ketone of formula (V) in which R2, R4 and R5 are as defined above, to reductive amination with an amine of formula R3NH2 in which R3 is an optionally substituted alkyl, and a reductant to form the compound of formula (VI), wherein the reaction is conducted in the presence of a supercritical fluid or a liquefied gas.Type: GrantFiled: August 26, 2002Date of Patent: February 13, 2007Assignees: Victoria University of Technology, Polychip Pharmaceuticals Pty. Ltd.Inventors: Andrew John Smallridge, Maurice Arthur Trewhella, Kylie Anne Wilkinson
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Patent number: 7063969Abstract: The invention provides a method of synthesis of a substituted or unsubstituted carbinol compound, comprising the steps of subjecting the corresponding substituted or unsubstituted aromatic aldehyde to acyloin condensation mediated by yeast in the presence of either (a) a supereritical fluid or (b) a liquefied gas, and recovering the carbinol compound. Preferably the yeast is Saccharomyces cerevisiae. In a particularly preferred embodiment the aromatic aldehyde is benzaldehyde and the carbinol is phenylacetylcarbinol, according to the reaction (I): in which the benzaldehyde, the pyruvic acid, or both may optionally be substituted.Type: GrantFiled: December 13, 2000Date of Patent: June 20, 2006Assignees: Victoria University of Technology, Polychip Pharmaceuticals Pty, Ltd.Inventors: Andrew John Smallridge, Maurice Arthur Trewhella, Kylie Anne Wilkinson
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Patent number: 6962907Abstract: The invention provides compounds of the formula II: wherein R represents propyl, butyl, pentyl, neo-pentyl or cyclohexyl, and salts thereof. These compounds are selective GABAC receptor antagonists. The invention also provides a method of enhancing the cognitive activity of an animal and a method of stimulating memory capacity in an animal, comprising administering to the animal an effective amount of a compound of formula II or a pharmaceutically acceptable salt thereof.Type: GrantFiled: November 29, 2002Date of Patent: November 8, 2005Assignees: The University of Sydney, Polychip Pharmaceuticals Pty. Ltd.Inventors: Mary Chebib, Jane Hanrahan, Graham A. R. Johnston
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Publication number: 20050084943Abstract: Organic compounds, such as precursors for aryl ethylamines such as ephedrine, aryl propylamines such as fluoxetine and propionic acid derivatives such as ibuprofen, naproxen and fenoprofen, are subjected to a yeast mediated reduction conducted in the absence of a solvent. The yeast is moistened with water and contacted with the organic compound. The yeast may then be contacted with an organic solvent to dissolve the product of the reaction into the solvent, and a solid/liquid separation used to separate the product from the yeast.Type: ApplicationFiled: March 31, 2004Publication date: April 21, 2005Applicants: Victoria University of Technology, Polychip Pharmaceuticals Pty LtdInventors: Maurice Trewhella, Nick Athanasiou, Andrew Smallridge
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Patent number: 6632806Abstract: The invention provides methods for enhancing cognitive activity and stimulating memory capacity, comprising the step of administering an effective amount of a compound with GABAC receptor antagonist activity to an animal in need of such treatment. Preferably the compound has selective GABAc receptor antagonist activity, and more preferably comprises a phosphinic acid group. The invention also provides novel compounds and compositions. The methods of the invention are useful in the treatment of dementias and conditions involving cognitive deficit, or memory impairment.Type: GrantFiled: December 22, 1999Date of Patent: October 14, 2003Assignees: The University of Sydney, Polychip Pharmaceuticals Pty. Ltd.Inventors: Graham A. R. Johnston, Peter M. Burden, Kenneth Noel Mewett, Mary Chebib
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Patent number: 6271008Abstract: This invention relates to yeast-mediated catalysis in organic solvents, and in particular the yeast-mediated condensation between pyruvate and a substituted aromatic aldehyde to yield the corresponding acyloin (hydroxy ketone) compound. The invention provides a method of synthesis of a substituted carbinol compound, comprising the step of subjecting the corresponding substituted aromatic aldehyde to acyloin condensation mediated by a yeast in an organic solvent under non-fermenting conditions. Preferably the yeast is Saccharomyces cerevisiae. In a preferred embodiment, the reaction is that between pyruvate and benzaldehyde to yield phenylacetylcarbinol, the precursor to ephedrine, to yield a product of high enantiomeric purity.Type: GrantFiled: February 20, 2001Date of Patent: August 7, 2001Assignees: Victoria University of Technology, Polychip Pharmaceuticals PTY LTDInventors: Andrew John Smallridge, Maurice Arthur Trewhella, Margaret Mary Del Guidice
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Patent number: 5929082Abstract: The invention provides novel sulphonylurea, sulphonylthiourea and sulphonylguanidine compounds which have the ability to block potassium ion channels regulated by intracellular concentrations of ATP. Methods of synthesis, pharmaceutical compositions and methods for the treatment of conditions such as type II diabetes, cardiac arrhythmias, ischaemic and hypoxic cardiovascular incidents, and cancers are also claimed.Type: GrantFiled: January 23, 1998Date of Patent: July 27, 1999Assignees: Polychip Pharmaceuticals Pty Ltd, The University of SydneyInventors: Noel John Chambers, Graham Allen Ross Johnston