Patents Assigned to PolyMASC Pharmaceuticals plc.
  • Process for fractionating polyethylene glycol (PEG) - protein adducts and an adduct of PEG and granulocyt-macrophage colony stimulating factor
    Publication number: 20020127244
    Abstract: The present invention provides adducts of polyethylene glycol and granulocyte-macrophage colony stimulating factor as well as methods for modifying a protein with pleiotropic activities which involve coupling polyethylene glycol to the protein.
    Type: Application
    Filed: March 12, 2002
    Publication date: September 12, 2002
    Applicant: PolyMASC Pharmaceuticals plc.
    Inventors: Cristina Delgado, Gillian Elizabeth Francis, Derek Fisher
  • Process for fractionating polyethylene glycol (PEG) —protein adducts and an adduct of PEG and granulocyt-macrophage colony stimulating factor
    Patent number: 6384195
    Abstract: The present invention provides adducts of polyethylene glycol and granulocyte-macrophage colony stimulating factor as well as methods for modifying a protein with pleiotropic activities which involve coupling polyethylene glycol to the protein.
    Type: Grant
    Filed: January 21, 1999
    Date of Patent: May 7, 2002
    Assignee: PolyMASC Pharmaceuticals plc.
    Inventors: Cristina Delgado, Gillian Elizabeth Francis, Derek Fisher
  • Tissue entrapment
    Publication number: 20020009488
    Abstract: Delivery of diagnostic and therapeutic agents to skin or solid tumours is improved by optimisation of the lipid containing macromolecular structures (eg liposomes) encapsulating the agents and the type and amount of hydrophilic moieties bound to the exterior of the macromolecular structures as well as the relative proportions of the various lipids or other hydrophobic entities forming the macromolecular structures.
    Type: Application
    Filed: December 14, 2000
    Publication date: January 24, 2002
    Applicant: POLYMASC PHARMACEUTICALS PLC
    Inventors: Gillian E. Francis, Derek Fisher
  • Liposomes
    Patent number: 6132763
    Abstract: Liposomes with covalently bound PEG moieties on the external surface which demonstrate improved serum half-life following intravenous administration are provided.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: October 17, 2000
    Assignee: PolyMASC Pharmaceuticals plc
    Inventor: Derek Fisher
  • Process for fractionating polyethylene glycol (PEG)-protein adducts and an adduct of PEG and granulocyte-macrophage colony stimulating factor
    Patent number: 5880255
    Abstract: The invention relates to fractionating a mixture of polyethylene glycol (PEG)-protein adducts having different degrees of PEG substitution by partitioning the PEG-protein adducts in a PEG-containing aqueous biphasic system according to the degree of PEG substitution. A new PEG-gm-CSF obtained by the process is useful in pharmaceutical compositions for use in therapeutic or diagnostic methods.
    Type: Grant
    Filed: April 14, 1995
    Date of Patent: March 9, 1999
    Assignee: PolyMASC Pharmaceuticals plc
    Inventors: Cristina Delgado, Gillian Elizabeth Francis, Derek Fisher