Patents Assigned to Polymedix, Inc.
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Publication number: 20130274502Abstract: The present invention provides methods for preparing a polymeric compound of Formula I: or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.Type: ApplicationFiled: December 19, 2012Publication date: October 17, 2013Applicant: PolyMedix, Inc.Inventors: Robert W. Kavash, Haizhong Tang, Carol Mulrooney, Dahui Liu
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Publication number: 20130252964Abstract: The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for killing or inhibiting the growth of a Candida or Aspergillus species or preventing or treating a mammal having candidiasis (oral and/or disseminated) or an Aspergillus infection.Type: ApplicationFiled: January 18, 2013Publication date: September 26, 2013Applicant: PolyMedix, Inc.Inventors: Richard W. Scott, Katie Freeman, Haizhong Tang, Gill Diamond
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Patent number: 8507723Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: GrantFiled: June 21, 2012Date of Patent: August 13, 2013Assignee: Polymedix, Inc.Inventors: Shaker Mousa, Dahui Liu
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Publication number: 20130137706Abstract: The present invention provides methods of inhibiting the growth of Mycobacterium species or treating an animal having a Mycobacterium infection (including multi-drug resistance strains and extensively drug resistant strains) by administering a compound of the invention, a salt thereof, or a composition comprising the same.Type: ApplicationFiled: October 23, 2012Publication date: May 30, 2013Applicant: POLYMEDIX, INC.Inventor: POLYMEDIX, INC.
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Publication number: 20130090345Abstract: The present invention provides arylamide compounds and methods of making and using them as antibiotics.Type: ApplicationFiled: August 1, 2012Publication date: April 11, 2013Applicant: POLYMEDIX, INC.Inventors: Willam F. DeGrado, Haizhong Tang, Bozena Korczak, Dahui Liu, Richard W. Scott, Yongjiang Xu
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Patent number: 8354556Abstract: The present invention provides methods for preparing a polymeric compound of Formula I: or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.Type: GrantFiled: October 21, 2010Date of Patent: January 15, 2013Assignee: PolyMedix, Inc.Inventors: Robert W. Kavash, Haizhong Tang, Carol Mulrooney, Dahui Liu
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Publication number: 20120322878Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: ApplicationFiled: June 21, 2012Publication date: December 20, 2012Applicant: POLYMEDIX, INC.Inventors: Shaker Mousa, Dahui Liu
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Publication number: 20120295922Abstract: The present invention provides methods for treating and/or preventing mucostitis with one or more compounds, or pharmaceutically acceptable salts thereof, disclosed herein, or compositions comprising the same.Type: ApplicationFiled: May 15, 2012Publication date: November 22, 2012Applicant: POLYMEDIX, INC.Inventors: Richard W. Scott, Bozena Korczak
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Publication number: 20120258141Abstract: The present invention provides compounds and compositions thereof that modulate the immune system.Type: ApplicationFiled: July 6, 2011Publication date: October 11, 2012Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, POLYMEDIX, INC.Inventors: Richard W. Scott, Gill Diamond
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Patent number: 8278309Abstract: The present invention provides arylamide compounds and methods of making and using them as antibiotics.Type: GrantFiled: October 26, 2009Date of Patent: October 2, 2012Assignee: PolyMedix, Inc.Inventors: William F. DeGrado, Dahui Liu, Richard W. Scott, Yongjiang Xu, Haizhong Tang, Bozena Korczak
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Patent number: 8232428Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: GrantFiled: March 10, 2010Date of Patent: July 31, 2012Assignee: PolyMedix,Inc.Inventors: Shaker Mousa, Dahui Liu
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Publication number: 20120115877Abstract: The present invention discloses compositions of facially amphiphilic compounds and their use in methods for treating or reducing cancers in animals, such as humans.Type: ApplicationFiled: August 20, 2011Publication date: May 10, 2012Applicant: POLYMEDIX, INC.Inventors: Richard W. Scott, Dylan Clements, Yongjiang Xu, Haizhong Tang, Carol Mulrooney, Ehab Khalil, Damian Weaver, Xiaodong Fan
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Patent number: 8129566Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: GrantFiled: December 17, 2010Date of Patent: March 6, 2012Assignee: PolyMedix, Inc.Inventors: Shaker Mousa, Dahui Liu
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Publication number: 20120039945Abstract: The present invention provides compounds and compositions thereof that modulate the immune system.Type: ApplicationFiled: July 6, 2011Publication date: February 16, 2012Applicants: UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY, POLYMEDIX, INC.Inventors: Richard W. Scott, Gill Diamond
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Publication number: 20110178104Abstract: The present invention provides compounds and methods for antagonizing the anticoagulant effect of an anticoagulant agent that is selected from UFH, LMWH, and a heparin/LMWH derivative in a patient comprising administering to the patient a compound of the invention or a salt thereof, or a composition comprising the same.Type: ApplicationFiled: January 5, 2011Publication date: July 21, 2011Applicant: POLYMEDIX INC.Inventors: Richard W. Scott, Dahui Liu, Robert W. Kavash, Trevor Young, Michael J. Costanzo, Carol Ann Mulrooney
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Publication number: 20110124664Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: ApplicationFiled: December 17, 2010Publication date: May 26, 2011Applicant: POLYMEDIX, INC.Inventors: Shaker Mousa, Dahui Liu
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Publication number: 20110098498Abstract: The present invention provides methods for preparing a polymeric compound of Formula I: or pharmaceutically acceptable salt thereof. The present invention also provides useful intermediates for preparing the compound of Formula I or pharmaceutically acceptable salt thereof.Type: ApplicationFiled: October 21, 2010Publication date: April 28, 2011Applicant: POLYMEDIX, INC.Inventors: Robert W. Kavash, Haizhong Tang, Carol Mulrooney, Dahui Liu
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Patent number: 7745662Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: GrantFiled: May 14, 2009Date of Patent: June 29, 2010Assignee: Polymedix, Inc.Inventor: Mousa Shaker
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Publication number: 20100105703Abstract: The present invention provides arylamide compounds and methods of making and using them as antibiotics.Type: ApplicationFiled: October 26, 2009Publication date: April 29, 2010Applicant: POLYMEDIX, INC.Inventors: William F. DeGrado, Dahui Liu, Richard W. Scott, Yongjiang Xu, Haizhong Tang, Bozena Korczak
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Publication number: 20090239811Abstract: Aspects of the present invention relate to compounds and methods useful in modulating angiogenesis and methods of treating or preventing diseases associated with angiogenesis by administering a polycationic compound. The present invention relates to methods of use and compositions for inhibiting angiogenesis-mediated disorders in mammals including animals and humans. Additionally, this invention relates to the combined use of polycations with other anti-angiogenesis agents for the treatment of different angiogenesis-mediated disorders. Additionally, those polycationic compounds can be used with various anti-inflammatory and cytotoxic agents as well as with radio-therapeutic agents in cancer patients to prevent and treat tumor growth and metastasis.Type: ApplicationFiled: May 14, 2009Publication date: September 24, 2009Applicant: POLYMEDIX, INC.Inventor: Mousa Shaker