Abstract: Conjugates comprising at least two active agents linked by a diglycolic acid or polyglycol diacid linker are disclosed. The invention also concerns oligomers and polymers of these conjugates and their use in therapeutic and industrial applications for localized, immediate or fast release delivery of an active agent, such as an anti-microbial, anti-infective, or antiseptic agent.
Type:
Grant
Filed:
July 9, 2015
Date of Patent:
October 9, 2018
Assignee:
Polymerix Corporation
Inventors:
Suseela Kanamathareddy, Karen J. Giroux
Abstract: Conjugates comprising at least two active agents linked by a diglycolic acid or polyglycol diacid linker are disclosed. The invention also concerns oligomers and polymers of these conjugates and their use in therapeutic and industrial applications for localized, immediate or fast release delivery of an active agent, such as an anti-microbial, anti-infective, or antiseptic agent.
Type:
Grant
Filed:
May 9, 2012
Date of Patent:
August 18, 2015
Assignee:
POLYMERIX CORPORATION
Inventors:
Suseela Kanamathareddy, Karen J. Giroux
Abstract: Medical devices with at least one surface comprising a polymer or polymers on the surface are provided. The polymer or polymers are capable of breaking down (e.g., including, but not limited to, hydrolyzing) in the physiologic milieu to form an active agent or agents under physiologic conditions, and can contain other active agents dispersed within or appended to the polymer matrix. Methods of delivering an active agent to an interior surface of a vein or artery are also provided.
Abstract: Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers are suitable for use in compositions, formulations, coatings, devices, and the like that benefit from the controlled release of an agent(s) over a period of time. The polymers are prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The polymers are suitable as delivery systems, either by themselves, as compositions, formulations or devices.
Type:
Application
Filed:
June 4, 2004
Publication date:
March 3, 2005
Applicant:
Polymerix Corporation
Inventors:
Anthony East, Alan Letton, Suseela Kanamathareddy, Bryant Pudil, Stephen Goodrich, Michael Hicks, Karen Giroux, Yun Choe