Abstract: A peptide probe that generates fluorescence signals rapidly upon recognition of various A? aggregates without significant perturbation of samples. The present peptide probes display an increase in fluorescence signals upon coincubation with A? oligomers, but neither monomeric/dimeric species nor fibrils. The detection can occur within an hour or two without any additional sample preparation and incubation steps.
Abstract: A strategy to improve protein stability by domain insertion. TEM 1 beta-lactamase (BLA) and exo-inulinase, as model target enzymes, are inserted into a hyperthermophilic maltose binding protein from Pyrococcus furiosus (PfMBP). Unlike conventional protein stabilization methods that employ mutations and recombinations, the inventive approach does not require any modification on a target protein except for its connection with a hyperthermophilic protein scaffold. For that reason, target protein substrate specificity was largely maintained, which is often modified through conventional protein stabilization methods. The insertion was achieved through gene fusion by recombinant DNA techniques.
Type:
Grant
Filed:
March 5, 2010
Date of Patent:
November 26, 2013
Assignee:
Polytechnic Institute of NYU
Inventors:
Jin Ryoun Kim, Brennal Pierre, Marc Ostermeier, Chung-Sei Kim
Abstract: The present invention provides a biocompatible material in the form of a water insoluble cross-linked gel, which contains a stable complex of TNF-stimulated gene 6 protein (TSG-6) and hyaluronan.
Type:
Grant
Filed:
November 18, 2011
Date of Patent:
April 16, 2013
Assignees:
New York University, Polytechnic Institute of NYU
Inventors:
Hans-Georg Wisniewski, Mary K. Cowman, Philip Band
Abstract: A method to monitor the progress of hybridization between nucleic acid strands in solution and Morpholino strands immobilized on a solid support such as a working electrode in-situ, in real-time, and using label-free electrochemical measurements sensitive to hybridization-induced changes in the near-surface dielectric constant and charge organization.
Type:
Grant
Filed:
January 29, 2009
Date of Patent:
September 11, 2012
Assignee:
Polytechnic Institute of NYU
Inventors:
Rastislav Levicky, Napoleon Tercero, Kang Wang, Ping Gong, Kenneth Shepard
Abstract: The present invention provides a biocompatible material in the form of a solid, a water insoluble cross-linked gel or a liposome, which contains a stable comples of TNF-stimulated gene 6 protein (TSG-6) and hyaluronan.
Type:
Application
Filed:
November 18, 2011
Publication date:
March 15, 2012
Applicant:
NEW YORK UNIVERSITY POLYTECHNIC INSTITUTE OF NYU
Inventors:
Hans-Georg WISNIEWSKI, Mary K. Cowman, Philip Band
Abstract: The present invention provides a biocompatible material in the form of a solid, a water insoluble cross-linked gel or a liposome, which contains a stable complexes of TNF-stimulated gene protein (TSG-6) and hyaluronan.
Type:
Grant
Filed:
February 17, 2009
Date of Patent:
January 10, 2012
Assignees:
New York University, Polytechnic Institute of NYU
Inventors:
Hans-Georg Wisniewski, Mary K. Cowman, Philip Band
Abstract: An extensometer having a loop of a single-mode optical fiber. At least two points of the loop are attached to desired locations on a specimen. Light is transmitted through the loop and the transmitted optical power is measured by a photodetector. The deformation of the specimen causes the size and shape of the loop to change, which changes the transmitted optical power. The change in optical power is related to extension or compression using calibration curves. The sensor works on the principle of transmitted power modulation through the curved section.
Abstract: The present invention provides a biocompatible material in the form of a solid, a water insoluble cross-linked gel or a liposome, which contains a stable comples of TNF-stimulated gene protein (TSG-6) and hyaluronan.
Type:
Application
Filed:
February 17, 2009
Publication date:
September 10, 2009
Applicants:
NEW YORK UNIVERSITY, POLYTECHNIC INSTITUTE OF NYU
Inventors:
Hans-Georg WISNIEWSKI, Mary K. Cowman, Philip Band