Abstract: To provide a method for testing a xenotransplantation material for pathogen infection, the method allowing redundant procedures in which the same test procedures are repeated using different primers for each pathogen to be at least reduced when a plurality of types of pathogens are tested for; a test kit; and a method for producing a xenotransplantation material product which has been evaluated for pathogen infection. A method for testing a xenotransplantation material for pathogen infection, the method comprising performing genetic tests for infection by pathogens comprising two or more types of bacteria and a virus or a protozoon, in which the genetic test for the two or more types of bacteria comprises using a primer that targets a common base sequence among at least two types of bacteria.
Abstract: Disease model pigs produced by nuclear transplantation, disease model pigs exhibiting stable phenotypes and production methods thereof are provided. Chimeric pigs for producing disease model pigs exhibiting stable phenotypes, genital glands thereof, and germ cells thereof are also provided. A method for producing a genetically modified disease model pig, includes: (a) transplanting a nucleus of a genetically modified cell into cytoplasm of an egg; (b) developing an obtained clonal embryo in a womb of a female pig to obtain an offspring; and mating the obtained offspring or having the offspring undergo sexual reproduction to further obtain the genetically modified offspring as a disease model pig.
Abstract: Provided is a method for developing a secondary organ by using a non-human animal in which organ formation is inhibited, for the purpose of establishing a process for producing a functional cell such as a ? cell within the body of an animal such as a pig, the method including the step of raising a newborn or a fetus of the non-human animal in which organ formation is inhibited by complementing at least a part of the function of the organ whose formation is inhibited.
Type:
Application
Filed:
October 6, 2021
Publication date:
January 27, 2022
Applicant:
PORMEDTEC CO., LTD.
Inventors:
Hiroshi NAGASHIMA, Hitomi MATSUNARI, Kazuaki NAKANO, Koki HASEGAWA
Abstract: Provided is a method for developing a secondary organ by using a non-human animal in which organ formation is inhibited, for the purpose of establishing a process for producing a functional cell such as a ? cell within the body of an animal such as a pig, the method including the step of raising a newborn or a fetus of the non-human animal in which organ formation is inhibited by complementing at least a part of the function of the organ whose formation is inhibited.
Type:
Grant
Filed:
September 18, 2018
Date of Patent:
November 16, 2021
Assignee:
PORMEDTEC CO., LTD.
Inventors:
Hiroshi Nagashima, Hitomi Matsunari, Kazuaki Nakano, Koki Hasegawa