Patents Assigned to Portal Instruments, Inc.
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Patent number: 12280244Abstract: An active injection guide concurrently monitors surface contact and an instantaneous contact force along an injection axis of an injector in order to ensure that the injector is properly positioned on a patient before an injection can be initiated.Type: GrantFiled: November 17, 2020Date of Patent: April 22, 2025Assignee: Portal Instruments, Inc.Inventors: Robert J. Dyer, Andrew Coats, Patrick Anquetil
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Patent number: 12239824Abstract: A needle-free injector includes a housing, a cartridge positioned within the housing, and a plunger slidably coupled to and disposed within the chamber, a motor operatively coupled to the plunger, the motor operable to actuate the plunger in the chamber, and a controller operatively coupled to the motor. The controller is operable to selectively operate the plunger according to any of a first delivery profile, a second delivery profile, and a third delivery profile. The controller may transition from the first delivery profile to the second delivery profile responsive to compression of a gas in the chamber, e.g., upon detecting a spike in a measured current applied to the motor. The controller may transition from the second delivery profile to the third delivery profile responsive to detecting a steady state condition between the measured current and a velocity of the plunger. Methods of delivering an injectate using the needle-free injectors are provided.Type: GrantFiled: September 4, 2020Date of Patent: March 4, 2025Assignee: Portal Instruments, Inc.Inventors: Tyler F. Barkin, Marc Pelletier
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Patent number: 12115353Abstract: An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.Type: GrantFiled: November 24, 2020Date of Patent: October 15, 2024Assignee: Portal Instruments, Inc.Inventors: Robert J. Dyer, Carl Tappan, Eric VanWyk
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Patent number: 12064602Abstract: A device for administering needle-free subcutaneous treatment to a patient comprises an actuator configured to deliver a plurality of volumes of a treatment at a plurality of locations on a body of the patient; at least one imaging device configured to detect a movement of the needle-free device from a first location on the body of the patient to a second location on the body of the patient; and a processor configured to determine the second location on the body of the device relative to the first location from the movement of the needle-free device relative to the first location on the body, the processor further configured to determine a volume of the plurality of volumes of the treatment to deliver to the body of the patient at the second location.Type: GrantFiled: June 20, 2023Date of Patent: August 20, 2024Assignee: Portal Instruments, Inc.Inventors: Patrick Armand Anquetil, Ian Hunter
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Patent number: 11980743Abstract: An apparatus for use in injectate delivery includes an actuator including a linkage, a force generating mechanism mechanically coupled to the linkage, and a controller coupled to the force generating mechanism. The force generating mechanism includes a passive force generator and an active force generator. In operation and on the basis of a control signal, the controller is configured to control the force generating mechanism to provide an input force to the linkage that is a combination of the first force provided by the passive force generator and a second force provided by the active force generator.Type: GrantFiled: August 10, 2020Date of Patent: May 14, 2024Assignee: Portal Instruments, Inc.Inventors: Andrew Coats, Robert J. Dyer
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Patent number: 11786666Abstract: A needleless injection system includes a pusher that pushes a plunger within a tapered bore of a cartridge. The pusher includes a nib, the tip of which is a ball.Type: GrantFiled: August 19, 2020Date of Patent: October 17, 2023Assignee: Portal Instruments, Inc.Inventors: Jessica Ong, Robert J. Dyer, Andrew Coats, Nikolay Lapin
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Patent number: 11715391Abstract: A needle-free injector conditionally detects a training cartridge based on the detected response to linear actuation of a plunger and enters a training mode instead of an injection mode.Type: GrantFiled: April 8, 2021Date of Patent: August 1, 2023Assignee: Portal Instruments, Inc.Inventor: Patrick Armand Anquetil
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Patent number: 11400220Abstract: An active injection guide concurrently monitors surface contact and an instantaneous contact force along an injection axis of an injector in order to ensure that the injector is properly positioned on a patient before an injection can be initiated.Type: GrantFiled: May 1, 2019Date of Patent: August 2, 2022Assignee: Portal Instruments, Inc.Inventors: Robert J. Dyer, Andrew Coats, Patrick Anquetil
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Patent number: 11344677Abstract: An injection guide globally aligns an injector to an angle selected for consistent subcutaneous delivery of an injectate, while locally aligning a patient's skin normal to the injection path at the location where the injection pierces the skin. This arrangement advantageously maintains controlled contact between an injector and a subject's skin in order to deliver the full, intended volume of injectate into the patient's subcutaneous layer while avoiding misdelivery into adjacent layers such as the patient's dermis or muscle.Type: GrantFiled: April 17, 2020Date of Patent: May 31, 2022Assignee: Portal Instruments Inc.Inventors: Pragun Goyal, Nikola Kojic
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Patent number: 10918808Abstract: An adapter for use with an injection device includes a first end, a second end and a first longitudinal axis extending from the first end and the second end. The adapter also includes a chamber defined by a sidewall between the first end and second end and a nozzle having a passageway extending through the sidewall, the passageway having an input at the chamber, an output at an outer surface of the body and a passageway axis extending from the input to the output, the passageway axis being angularly offset from the longitudinal axis of the channel. A cartridge can include such an adapter.Type: GrantFiled: March 9, 2017Date of Patent: February 16, 2021Assignee: Portal Instruments, Inc.Inventors: Andrew Coats, Robert J. Dyer
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Patent number: 10857297Abstract: An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.Type: GrantFiled: September 17, 2019Date of Patent: December 8, 2020Assignee: Portal Instruments, Inc.Inventors: Robert J. Dyer, Carl Tappan, Eric VanWyk
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Patent number: 10857298Abstract: An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.Type: GrantFiled: September 17, 2019Date of Patent: December 8, 2020Assignee: Portal Instruments, Inc.Inventors: Robert J. Dyer, Carl Tappan, Eric VanWyk
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Patent number: 10850038Abstract: An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.Type: GrantFiled: September 17, 2019Date of Patent: December 1, 2020Assignee: Portal Instruments, Inc.Inventors: Robert J. Dyer, Carl Tappan, Eric VanWyk
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Patent number: 10842467Abstract: Needle-less extraction of a biospecimen from tissue having a number of tissue layers including an epidermis layer includes creating a first port through a target surface and into an underlying one of the tissue layers, creating a second port through the target surface and into the underlying one of tissue layers, providing an injectate through the first port to the underlying one of the tissue layers underlying the epidermis layer, and extracting at least a portion of the injectate and the biospecimen from the underlying one of the layers through the second port.Type: GrantFiled: December 14, 2016Date of Patent: November 24, 2020Assignee: Portal Instruments, Inc.Inventor: Andrew Coats
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Patent number: 10737032Abstract: An apparatus for use in injectate delivery includes an actuator including a linkage, a force generating mechanism mechanically coupled to the linkage, and a controller coupled to the force generating mechanism. The force generating mechanism includes a passive force generator and an active force generator. In operation and on the basis of a control signal, the controller is configured to control the force generating mechanism to provide an input force to the linkage that is a combination of the first force provided by the passive force generator and a second force provided by the active force generator.Type: GrantFiled: November 25, 2015Date of Patent: August 11, 2020Assignee: Portal Instruments, Inc.Inventors: Andrew Coats, Robert J. Dyer
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Patent number: 10625020Abstract: An injection guide globally aligns an injector to an angle selected for consistent subcutaneous delivery of an injectate, while locally aligning a patient's skin normal to the injection path at the location where the injection pierces the skin. This arrangement advantageously maintains controlled contact between an injector and a subject's skin in order to deliver the full, intended volume of injectate into the patient's subcutaneous layer while avoiding misdelivery into adjacent layers such as the patient's dermis or muscle.Type: GrantFiled: November 21, 2016Date of Patent: April 21, 2020Assignee: Portal Instruments, Inc.Inventors: Pragun Goyal, Nikola Kojic
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Patent number: 10625021Abstract: An apparatus for transdermal injection includes a collet configured to transition between first and second states. In the first state, the collet receives a cartridge with a predetermined elongate shape. In the second state, an inner surface of the collet substantially conforms to the predetermined elongate shape of the cartridge such that expansion of the cartridge, when the cartridge is pressurized, is substantially uniformly opposed.Type: GrantFiled: January 31, 2017Date of Patent: April 21, 2020Assignee: Portal Instruments, Inc.Inventors: Robert J. Dyer, Andrew Coats, Nikolay Lapin
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Patent number: 10532158Abstract: An injection device for use with a cartridge containing an injectate includes a housing. The housing includes an end wall at its distal end and an inner wall. The inner wall extends in a direction from the proximal end of the housing to the distal end of the housing and separates a first chamber from a second chamber in the housing. The housing includes a first opening disposed in the end wall and is in fluid communication with the first chamber. The housing includes a second opening is in fluid communication with the second chamber. A coupler is disposed in the first chamber for coupling to the cartridge. The first opening and the second opening are in fluid communication via a channel for transfer of fluid between the first chamber and the second chamber.Type: GrantFiled: October 9, 2015Date of Patent: January 14, 2020Assignee: Portal Instruments, Inc.Inventors: Robert J. Dyer, Andrew Coats
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Patent number: 10413671Abstract: An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.Type: GrantFiled: September 12, 2018Date of Patent: September 17, 2019Assignee: Portal Instruments, Inc.Inventors: Robert J. Dyer, Carl Tappan, Eric VanWyk
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Patent number: 10376656Abstract: An injector cartridge is configured for sterile storage and transfer of a fluid in a pre-filled syringe. The injector cartridge includes a first housing section and a second housing section and is configured to move the pre-filled syringe from a sterile storage position to a fluid transfer position upon linear displacement of the first housing section relative to the second housing section.Type: GrantFiled: May 18, 2017Date of Patent: August 13, 2019Assignee: Portal Instruments, Inc.Inventors: Robert J. Dyer, Andrew Coats