Abstract: The present disclosure provides a scalable and cost-effective method of purifying recombinant viruses, such as recombinant lentiviruses. Also provided herein are recombinant viruses (e.g., lentiviruses) purified using the methods provided herein, which have a low level of impurities and high activity retention.
Type:
Grant
Filed:
October 25, 2022
Date of Patent:
January 23, 2024
Assignee:
PORTON ADVANCED SOLUTIONS LTD.
Inventors:
Dichao Hu, Chuanzhen Pi, Kai Weng, Jinbo Guo, Hailong Liu, Yangzhou Wang, Weimeng Zhang, Jun Hua