Patents Assigned to PORTON PHARMA SOLUTIONS LTD.
  • Method of preparation of (1R,3S)-3-amino-1-cyclopentanol and salt thereof
    Patent number: 11459291
    Abstract: Provided is a method of preparation of (1R, 3S)-3-amino-1-cyclopentanol, the method including: contacting N-acylhydroxyamine and cyclopentadiene for an asymmetric cycloaddition, to yield a first intermediate I; hydrogenating the first intermediate I to yield a second intermediate II; hydrolyzing, ammonolyzing, hydrazinolyzing, or alcoholyzing an amido bond of the second intermediate II to yield a third intermediate III; and hydrogenating the third intermediate III to yield (1R, 3S)-3-amino-1-cyclopentanol.
    Type: Grant
    Filed: January 31, 2021
    Date of Patent: October 4, 2022
    Assignee: PORTON PHARMA SOLUTIONS LTD.
    Inventors: Wenqing Lin, Hongjie Zheng, Jianping Zhu, Yong Zhang, Jianchong Wang