Abstract: Certain 1,5-disubstituted benzimidazol-2-one compounds useful as therapeutic agents. The compounds may be of the Formula I wherein: R? represents hydrogen or alkyl; R? represents halogen or trihalogenmethyl; and Hlg represents halogen; provided, however, that if Hlg is F, then R? is not Cl. Also, use of the 1,5-disubstituted benzimidazol-2-one compounds, or pharmaceutically-acceptable addition salts thereof, in applications that benefit from increasing the blood-brain barrier permeability.
Type:
Grant
Filed:
June 17, 2003
Date of Patent:
July 17, 2007
Assignee:
Poseidon Pharmaceuticals A/S
Inventors:
Lars Siim Madsen, Camilla ærteberg Bæk, Annette Lauridsen, Søren Peter Olesen
Abstract: This invention relates to novel compounds useful as potassium channel modulators. More specifically the invention provides chemical compounds useful as modulators of SKCa and/or IKCa channels.
Type:
Grant
Filed:
January 6, 2003
Date of Patent:
April 24, 2007
Assignee:
Poseidon Pharmaceuticals A/S
Inventors:
Alex Haahr Gouliaev, Frank Abildgaard Slok, Lene Teuber, Joachim Demnitz
Abstract: The present invention relates to ion channel modulating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as modulators of SK Ca, IK Ca and BK Ca channels. In further aspects, the present invention relates to the use of these SK/IK/BK channel modulating agents for the manufacture of medicaments, for methods of therapy, and pharmaceutical compositions comprising the SK/IK/BK channel modulating agents. The SK/IK/BK channel modulating agents of the invention are useful for the treatment or alleviation of diseases and conditions associated with the SK/IK/BK channels.
Abstract: The present invention relates to chemical compounds having inhibitory activity on an intermediate conductance Ca2+ activated potassium channel (IKCa), and the use of such compounds for the treatment or alleviation of diseases or conditions relating to immune dysfunction.
Type:
Grant
Filed:
November 9, 2001
Date of Patent:
September 28, 2004
Assignee:
Poseidon Pharmaceuticals A/S
Inventors:
Bo Skaaning Jensen, Soren Peter Olsen, Palle Christophersen