Abstract: A plumbing distribution and control panel system is provided. The plumbing distribution and control panel system has a main control panel unit having an interior. A portion of each of a plurality of pipes of a residence or commercial building may pass through the control panel to various zones of the building such as, for example, a water heater or tankless heater, a kitchen, a bathroom, a utility room, a laundry room, a basement, an exterior unit, or a mechanical room of a commercial building. The main control panel may allow a user to control the flow of water through the pipes in those zones. The main control panel allows for the easy cut-off of flowing water which may prevent damage to the residence or commercial building. A wireless system may also allow a user to wirelessly control the flow of water through the pipes.