Abstract: An approach to genetic vaccine methodology is described. A genetic construction encoding antigenic determinants of a filovirus is transfected into cells of the vaccinated individuals using a particle acceleration protocol so as to express the viral antigens in healthy cells to produce an immune response to those antigens.
Type:
Grant
Filed:
December 4, 1996
Date of Patent:
March 13, 2001
Assignee:
PowerJect Vaccines Inc.
Inventors:
Joel R. Haynes, Connie S. Schmaljohn, Deborah L. Fuller, Alan Schmaljohn, Peter B. Jahrling