Patents Assigned to PPD Discovery, Inc.
  • Prenylation inhibitors and methods of their synthesis and use
    Patent number: 7501444
    Abstract: The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: March 10, 2009
    Assignee: PPD Discovery, Inc.
    Inventors: Bradley B. Brown, Kenneth S. Rehder
  • Prenylation inhibitors and methods of their synthesis and use
    Patent number: 7501446
    Abstract: The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
    Type: Grant
    Filed: January 1, 2007
    Date of Patent: March 10, 2009
    Assignee: PPD Discovery, Inc.
    Inventors: Francine Feirong Li, Kenneth S. Rehder, Michael Gordon Campbell, Celeste Patrice Viscardi, Jon-Paul Strachan, Zhengming Guo
  • Prenylation inhibitors and methods of their synthesis and use
    Patent number: 7112596
    Abstract: The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
    Type: Grant
    Filed: September 27, 2005
    Date of Patent: September 26, 2006
    Assignee: PPD Discovery, Inc.
    Inventors: Bradley B. Brown, Kenneth S. Rehder
  • Prenylation inhibitors and methods of their synthesis and use
    Publication number: 20060025454
    Abstract: The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
    Type: Application
    Filed: September 27, 2005
    Publication date: February 2, 2006
    Applicant: PPD Discovery, Inc.
    Inventors: Bradley Brown, Kenneth Rehder
  • Prenylation inhibitors and methods of their synthesis and use
    Patent number: 6960603
    Abstract: The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
    Type: Grant
    Filed: August 22, 2003
    Date of Patent: November 1, 2005
    Assignee: PPD Discovery, Inc.
    Inventors: Bradley B. Brown, Kenneth S. Rehder
  • Prenylation inhibitors and methods of their synthesis and use
    Publication number: 20040053970
    Abstract: The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
    Type: Application
    Filed: August 22, 2003
    Publication date: March 18, 2004
    Applicant: PPD Discovery, Inc.
    Inventors: Bradley B. Brown, Kenneth S. Rehder
  • Prenylation inhibitors containing dimethylcyclobutane and methods of their synthesis and use
    Patent number: 6664277
    Abstract: The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: December 16, 2003
    Assignee: PPD Discovery, Inc.
    Inventors: Bradley B. Brown, Kenneth S. Rehder, Jon-Paul Strachan, Jeron H. Eaves, Christopher T. Lowden
  • Prenylation inhibitors and methods of their synthesis and use
    Patent number: 6649638
    Abstract: The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: November 18, 2003
    Assignee: PPD Discovery, Inc.
    Inventors: Bradley B. Brown, Kenneth S. Rehder
  • Pyrazole compounds and uses thereof
    Patent number: 6191147
    Abstract: The present invention is directed to compounds of the formula: and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same, where R1, R2, R3, R4, R5, R6, R7 and X are defined herein.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: February 20, 2001
    Assignees: PPD Discovery, Inc., Duke University
    Inventors: Bradley B. Brown, Patrick J. Casey, Casey Pritchard Purdy, Zita Latona, Sarah Tavares