Abstract: An imaging device for image generation of a specimen is disclosed. Layers of images may be captured by an optical system and then compiled to create an integrated image. Each layer may include a different focal point. A consolidated image may then be created by combining one or more integrated images.

Abstract: A system and method for automated slide retrieval and scanning is disclosed. The system comprises at least a processor configured to receive, from a user, a set of scan requirements, identify a current slide configuration, generate an operational scan sequence based on the received scan requirements and the current slide configuration, and execute the generated operational scan sequence.

Abstract: An apparatus for imaging a slide, the apparatus including at least an optical system, including an optical sensor, a slide port configured to hold the slide, at least a processor, and a memory communicatively connected to the at least a processor, the memory containing instructions configuring the at least a processor to receive at least a region of interest, capture, using the at least an optical system, a plurality of first images of the slide at a first position within the at least a region of interest, wherein each of the plurality of first images has a different focus distance, and identify a focus pattern.

Abstract: A system of digitalizing a slide, comprising at least one imaging device and a computing device communicatively connected to the imaging device, wherein the computing device is configured to scan each slide of a plurality of slides at the imaging device to generate an initial slide image and associated scanning metadata for each slide, determine a quality control metric for each slide as a function of the initial slide image and the associated scanning metadata, wherein determining the quality control metric includes flagging the slide based on the determined quality control metric, generate at least one scanning profile as a function of the scanning metadata based on the quality control metric, and re-scan the flagged slides at the imaging device using the at least one scanning profile.

Abstract: A system for detecting and cleaning contaminants from an imaging optical path, comprising an imaging device configured to receive a slide and capture a first slide image, at least a computing device configured to determine a contaminant presence indicator associated with a contaminant within an optical path of the imaging device based on the first slide image and execute a contaminant cleaning protocol as a function of the contaminant presence indicator, a contaminant removal mechanism configured to remove the contaminant from the optical path according to the contaminant cleaning protocol, wherein the computing device is further configured to re-evaluate the contaminant presence indicator based on a second slide image of the slide captured using the imaging device and request a user input upon a positive re-evaluation of the contaminant presence indicator.

Abstract: An apparatus and method of use of a mechanism that converts rotary motion into linear motion are disclosed. The method includes mechanically connecting, using a first connecting component, a rotary component and one or more movable components, mechanically connecting, using a second connecting component, a plurality of gripping components and the one or more movable components, generating, using the rotary component, rotary motion about a rotational axis, transferring, using the first connecting component, the rotary motion to the one or more movable components, transferring, using the second connecting component, the off-axis motion of the one or more movable components to the plurality of gripping components and moving the plurality of gripping components linearly in opposite directions.

Abstract: A method for visualization of digitized slides is disclosed. The method comprises retrieving, by one or more computer processors, a digitized slide, determining, by the one or more computer processors, one or more visualization components of the digitized slide, generating, by the one or more computer processors, a virtual slide corresponding to the digitized slide based on the one or more visualization components, and displaying, by the one or more computer processors, a visualization of the virtual slide.

Abstract: An apparatus for identifying regions of interest during slide digitization is disclosed. The apparatus includes at least processor and a memory communicatively connected to the processor. The memory contains instructions configuring the processor to receive a user dataset associated with at least a pathology slide. The memory contains instructions configuring the processor to identify one or more regions of interest within at least a pathology slide as a function of the user dataset. The memory contains instructions configuring the processor to identify at least one scan parameter as a function of the one or more regions of interest. The memory contains instructions configuring the processor to generate a digitized slide by scanning the at least a pathology slide as a function the at least one scan parameter.

Abstract: The present disclosure describes an exemplary system and method for the digitization of tissue slides based on associations among serial sections. The system includes at least a computing device, wherein the computing device includes a memory and processor communicatively connected to one another, and a scanner, configured to scan a slide and send a digitized image of the slide to the computing device. A method for the digitization of tissue slides based on associations among serial sections may include receiving a candidate tissue map associated with a candidate tissue section, receiving a reference tissue map associated with a reference tissue section, aligning the candidate tissue map to the reference tissue map, comparing the aligned candidate tissue map to the reference tissue map, and generating a regenerated candidate tissue map as a function of the reference tissue map.

Abstract: A method for visualization of digitized slides is disclosed. The method comprises retrieving, using at least a processor, a digitized slide, determining, using the at least a processor, one or more visualization components of the digitized slide, generating, using the at least a processor, a virtual slide corresponding to the digitized slide based on the one or more visualization components, conditionally adjusting, using the at least a processor, a parameter of the virtual slide using one or more predefined temples, and displaying, using a user display, a visualization of the virtual slide.

Abstract: An exemplary apparatus according to this disclosure includes at least a display, a processor, and a memory communicatively connected to the processor. The processor generates a display data structure comprising a plurality of visual elements, configures a display device to display the visual elements, receives an activation of an event handler of the plurality of event handlers, wherein receiving the activation further comprises receiving a user selection of a visual element of the plurality of visual elements that is linked to the event handler, and executes the algorithm module associated with the activated event handler comprising an image processing module configured to receive an initial image and output a modified image.

Abstract: A system for microscopy slide locking include a stage slot configured to fit a microscopy slide, the stage slot including a first corner and a second corner diagonally across the first corner, a static securing element disposed at the first corner and configured to contact a microscopy slide at a first pair of its orthogonal, intersecting edges, and a dynamic securing element disposed at the second corner and configured to contact the microscopy slide at a second pair of its orthogonal, intersecting edges diagonally opposite the first pair of its orthogonal, intersecting edges, wherein the dynamic securing element includes a translating portion configured to slide in a translational direction between a proximal position and a distal position and a rotating portion rotationally connected to the translating portion and configured to rotate around an axis of rotation normal to a face of the microscopy slide and the translational direction.

Abstract: An apparatus for visualization of digitized glass slides belonging to a patient case having a processor and a memory communicatively connected to the processor, the memory containing instructions configuring the processor to receive an image data set having a plurality of images of one or more specimens and metadata of the plurality of images of the one or more specimens, identify one or more constituent virtualization components for each image, determine a relationship between the one or more constituent visualization components as a function of the image data set, construct a plurality of virtual images as a function of the image data set and the relationship between the one or more virtual constituent components, wherein each of plurality of the images includes at least one virtual constituent component, generate a consolidated virtual image as a function of the plurality of virtual images and display the consolidated virtual image.

Abstract: An apparatus for generating a confidence score associated with a scanned label is disclosed. The apparatus includes at least a processor and a memory communicatively connected to the at least a processor. The memory instructs the processor to receive a profile, wherein the profile includes at least a label and a plurality of digital representations of slides, perform a flip detection process on the profile to verify the orientation of at least slide data of the profile, generate a scanned label as a function of the at least a label, determine a confidence score associated with the scanned label, adjust the confidence score for accuracy, and display the confidence score using a display device.

Abstract: A system for color gamut normalization for pathology slides, the system including at least computing device, wherein the computing device is configured to receive a whole slide image, generate a plurality of segments associated with the whole slide image as a function of one or more biological tissue type variabilities, apply a segment-specific transformation to each segment of the plurality of segments, create a user interface data structure, wherein the user interface data structure includes the plurality of segments and display the plurality of segments through a graphical user interface as a function of the user interface data structure.

Abstract: An apparatus and method for adaptive handling of slides using a robot arm. The apparatus includes at least a computing device comprised of a processor and a memory communicatively connected to the processor. The memory instructs the processor to receive a calibration procedure, wherein the calibration procedure is generated using a plurality of waypoints. The processor controls the at least a robotic arm as a function of the calibration procedure, wherein the calibration procedure is configured to cause the robotic arm to pick, using a pick waypoint of the plurality of waypoints, and place, using a place waypoint of the plurality of waypoints, a slide. The processor receives a plurality of feedback from the at least a robotic arm. The processor generates, using the plurality of feedback, an adapted pick waypoint. The memory instructs the processor to generate, using the plurality of feedback, an adapted place waypoint.

Abstract: An apparatus and method for detecting content of interest on a slide using machine learning. The apparatus includes at least a processor and a memory communicatively connected to the at least a processor. The memory instructs the processor to receive a first image, comprising a macro image, identify areas of interest associated with the grids of the first image, receive a second image comprising a high magnification image associated with the areas of interest of the first image, classify, using at least a probed point, the grids of the first image, wherein classifying the grids of the first image includes classifying the grids into accepted grids of the grids and rejected grids of the grids, scan, using the image capturing device, the accepted grids to generate an output image, and display, using a display device, the output image.

Abstract: The present disclosure describes an exemplary system and method for the digitization of tissue slides based on associations among serial sections. The system includes at least a computing device, wherein the computing device includes a memory and processor communicatively connected to one another, and a scanner, configured to scan a slide and send a digitized image of the slide to the computing device. A method for the digitization of tissue slides based on associations among serial sections may include receiving a candidate tissue map associated with a candidate tissue section, receiving a reference tissue map associated with a reference tissue section, aligning the candidate tissue map to the reference tissue map, comparing the aligned candidate tissue map to the reference tissue map, and generating a regenerated candidate tissue map as a function of the reference tissue map.

Abstract: An apparatus for identifying regions of interest during slide digitization is disclosed. The apparatus includes at least processor and a memory communicatively connected to the processor. The memory contains instructions configuring the processor to receive a user dataset associated with at least a pathology slide. The memory contains instructions configuring the processor to identify one or more regions of interest within at least a pathology slide as a function of the user dataset. The memory contains instructions configuring the processor to identify at least one scan parameter as a function of the one or more regions of interest. The memory contains instructions configuring the processor to generate a digitized slide by scanning the at least a pathology slide as a function the at least one scan parameter.

Abstract: An imaging device for image generation of a specimen is disclosed. Layers of images may be captured by an optical system and then compiled to create an integrated image. Each layer may include a different focal point. A consolidated image may then be created by combining one or more integrated images.