Patents Assigned to PRECISION GENOME ENGINEERING, INC.
  • Laglidadg homing endonuclease cleaving the C-C chemokine receptor type-5 (CCR5) gene and uses thereof
    Patent number: 10006052
    Abstract: Disclosed herein are compositions for inactivating the human CCR5 gene comprising engineered LAGLIDADG homing endonucleases (LHEs) and their derivatives, particularly derived from members of the \-Onul subfamily of LHE. Polynucleotides encoding such endonucleases, vectors comprising said polynucleotides, cells comprising or having been treated with such endonucleases, and therapeutic compositions deriving therefrom are also provided.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: June 26, 2018
    Assignees: CELLECTIS, PRECISION GENOME ENGINEERING, INC.
    Inventors: Jordan Jarjour, Alexander Astrakhan
  • LAGLIDADG homing endonuclease cleaving the T cell receptor alpha gene and uses thereof
    Patent number: 10000746
    Abstract: Disclosed herein are compositions for inactivating the human TCR-alpha gene comprising engineered LAGLIDADG homing endonucleases (LHEs) and their derivatives, particularly derived from members of the \-Onul subfamily of LHEs. Polynucleotides encoding such endonucleases, vectors comprising said polynucleotides, cells comprising or having been treated with such endonucleases, and therapeutic compositions deriving therefore are also provided.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: June 19, 2018
    Assignees: CELLECTIS, PRECISION GENOME ENGINEERING, INC.
    Inventors: Jordan Jarjour, Alexander Astrakhan