Patents Assigned to Precision NanoSystems ULC
  • Compositions for transfecting resistant cell types
    Patent number: 11679159
    Abstract: A reagent composition for delivery nucleic acid therapeutics to cells is provided. The reagent includes ionizable lipid, structural lipid, and a stabilizing agent which improves the transfection efficiency of nucleic acids, and leaves transfected cells viable. The 5 transfection reagent is effective in plasmid and mRNA delivery, and in neurons and progenitor-like cells. It may be used for ex vivo cell therapy.
    Type: Grant
    Filed: April 15, 2019
    Date of Patent: June 20, 2023
    Assignee: Precision Nanosystems ULC
    Inventors: Anitha Thomas, Andrew William Brown, Rebecca Anne Grace De Souza, Tara L. Fernandez
  • Compositions for transfecting resistant cell types
    Patent number: 11572575
    Abstract: A transfection reagent composition comprising: 30-60 MOL. % of a cationic lipid, or a pharmaceutical acceptable salt thereof; 10-60 MOL % of a structural lipid; 10-20 MOL % of a triglyceride; and 0.1 to about 10 MOL. % of a stabilizing agent, is provided. The transfection agent is effective in transfecting cells, particularly neurons, with siRNA, mRNA and plasmid nucleic acid, Sand maintaining viability of the cells as well as activity of the delivered nucleic acid.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: February 7, 2023
    Assignee: Precision NanoSystems ULC
    Inventors: Anitha Thomas, Rebecca Anne Grace De Souza, Eric Ouellet, Grace Tharmini Tharmarajah, Jagbir Singh, Shyam Madhusudan Garg