Abstract: A method for inducing necrosis in susceptible malignant cells, comprises two general steps. First, positioning a collection of cells containing the susceptible malignant cells within a treatment domain, wherein the treatment domain is subjected to a non-ionizing radiation field. Second, pulsing said non-ionizing radiation field with a frequency and an intensity selected to produce necrosis in the susceptible malignant cells by creating a transmembrane potential that causes an increase in ionic diffusion in the susceptible malignant cells or generates reversible electroporation of the susceptible malignant cells. Though both malignant and non-malignant cells may be reversibly porated, it is posited that many forms of cancer will be more vulnerable to the subject procedure.