Abstract: The present disclosure provides, in some aspects, nucleic acid-based molecular tools that enable the recording of molecular structure and soluble signals as well as the programmed assembly of molecular structures.
Type:
Application
Filed:
February 16, 2017
Publication date:
April 11, 2019
Applicant:
President and Fellows of Harward College
Inventors:
Jocelyn Yoshiko Kishi, Thomas E. Schaus, Peng Yin, Feng Xuan, Nikhil Gopalkrishnan, Sungwook Woo
Abstract: Specific cortistatin derivatives with advantageous properties for in vivo administration to a host, including a human, in need thereof are provided. These novel species have advantageous pharmacokinetics, low toxicity, low to moderate hERG activity, and/or other pharmacological properties which make them stand out among the class of cortistatins as superior candidates for human administration.
Type:
Application
Filed:
December 21, 2016
Publication date:
February 28, 2019
Applicant:
President and Fellows of Harward College
Inventors:
Matthew D. SHAIR, Henry Efrem PELISH, Jae Young AHN
Abstract: The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.
Type:
Application
Filed:
July 15, 2014
Publication date:
May 26, 2016
Applicant:
PRESIDENT AND FELLOWS OF HARWARD COLLEGE
Inventors:
Mark J. CARTWRIGHT, Nazita GAMINI, Donald E. INGBER, Martin ROTTMAN, Michael SUPER, Julie A. TOMOLONIS, Karen A. SINCLAIR