Patents Assigned to PRESIDENT & FELLOWS OF HARVARD
  • 3-d printed devices formed with magnetic inks and methods of making graded index structures
    Patent number: 11845219
    Abstract: A 3-D printed device comprising one or more structures, the structures comprising a plurality of magnetically responsive particles and one or more diblock or triblock copolymers; the diblock or triblock copolymers having an A-B, A-B-A, or A-B-C block-type structure in which the A-blocks and C-blocks are an aromatic-based polymer or an acrylate-based polymer and the B-blocks are an aliphatic-based polymer. These 3-D printed devices may be formed using a method that comprises providing a magnetic ink composition; applying the magnetic ink composition to a substrate in a 3-D solvent cast printing process to form one or more structures; and drying the one or more structures formed from the magnetic ink composition. The dried structures can exhibit one or more regions of magnetic permeability greater than 1.3×10?6 H/m.
    Type: Grant
    Filed: May 1, 2020
    Date of Patent: December 19, 2023
    Assignees: Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Theodore H. Fedynyshyn, Jennifer A. Lewis, Bradley P. Duncan
  • WW-DOMAIN-ACTIVATED EXTRACELLULAR VESICLES
    Publication number: 20230398202
    Abstract: Disclosed herein are methods, systems, compositions and strategies for the creation and use WW-domain-Activated Extracellular Vesicles, or WAEVs. These WAEVs can be harnessed to deliver and present viral or bacterial antigens useful for vaccine development; to display homing molecules for targeted delivery of therapeutic molecules to specific cells or tissues; and for packaging and delivery of therapeutic molecules via interactions with the WW domains.
    Type: Application
    Filed: October 15, 2021
    Publication date: December 14, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: Quan Lu, Sengjin Choi
  • PROGRAMMABLE METAMATERIAL AND METHOD OF CONTROLLING MACROSCOPIC PROPERTIES OF A METAMATERIAL
    Publication number: 20230398729
    Abstract: A method of controlling macroscopic properties of a metamaterial includes 3D printing a lattice structure comprising interconnected struts, where each strut comprises one or more printed filaments. Each printed filament comprises an active material or a passive material, and the active material has a modulus with a higher stimulus dependence than that of the passive material. The printed filaments comprising the active material are disposed at predetermined regions of the lattice structure. After 3D printing, the lattice structure is exposed to a stimulus, and the predetermined regions comprising the active material soften or stiffen. Thus, the macroscopic properties of the lattice structure may be controlled.
    Type: Application
    Filed: November 11, 2021
    Publication date: December 14, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: Jochen MUELLER, Jennifer A. LEWIS, Katia BERTOLDI
  • WW-DOMAIN-ACTIVATED EXTRACELLULAR VESICLES TARGETING HIV
    Publication number: 20230390382
    Abstract: Disclosed herein are methods, systems, compositions and strategies for the creation and use WW-domain-Activated Extracellular Vesicles (WAEVs) for presenting HIV antigen domains. These WAEVs can be harnessed to deliver and present HIV antigens useful for vaccine development. Specifically, the disclosure provides a fusion protein comprising: (a) a WW-containing domain; (b) a transmembrane domain; and (c) an extracellular domain, wherein the extracellular domain is an HIV antigen domain. Further provided are sequences of each domain as well as methods of producing and using the fusion protein.
    Type: Application
    Filed: October 15, 2021
    Publication date: December 7, 2023
    Applicants: President and Fellows of Harvard College, Board of Regents of the University of Nebraska
    Inventors: Quan Lu, Shi-Hua Xiang
  • WW-DOMAIN-ACTIVATED EXTRACELLULAR VESICLES TARGETING CORONAVIRUSES
    Publication number: 20230391834
    Abstract: Disclosed herein are methods, systems, compositions and strategies for the creation and use WW-domain-Activated Extracellular Vesicles, or WAEVs for presenting SARS-CoV-2 antigen domains, for example the SARS-CoV-2 M protein, the SARS-CoV-2 E protein, or the SARS-CoV-2 S protein. These WAEVs can be harnessed to deliver and present SARS-CoV-2 antigens useful for vaccine development.
    Type: Application
    Filed: October 15, 2021
    Publication date: December 7, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: Quan Lu, Sengjin Choi
  • Meta-lens doublet for aberration correction
    Patent number: 11835680
    Abstract: An optical device comprises a first meta-lens and a second meta-lens. The first meta-lens includes a first plurality of nanostructures that define a first phase profile of the first meta-lens. The second meta-lens includes a second plurality of nanostructures that define a second phase profile of the second meta-lens. A combination of the first meta-lens having the first phase profile and the second meta-lens having the second phase profile is configured to achieve a diffraction-limited focusing and correct an aberration of light transmitted through the optical device.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: December 5, 2023
    Assignee: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Benedikt Groever, Wei-Ting Chen, Federico Capasso
  • Single cell nucleic acid detection and analysis
    Patent number: 11834712
    Abstract: Methods and compositions for digital profiling of nucleic acid sequences present in a sample are provided.
    Type: Grant
    Filed: March 2, 2023
    Date of Patent: December 5, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: Xiaoliang Sunney Xie, Katsuyuki Shiroguchi, Peter A. Sims, Tony Z. Jia
  • Topology optimized multi-layered meta-optics
    Patent number: 11835681
    Abstract: A multi-layered lens comprises a plurality of metasurface layers. At least some layers of the plurality of metasurface layers include features that exhibit angular phase controls. The angular phases of the at least some layers cause an angular aberration correction or an angle convergence that focuses light onto a focal point regardless of angles of incidence.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: December 5, 2023
    Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, PRINCETON UNIVERSITY
    Inventors: Zin Lin, Federico Capasso, Alejandro W. Rodriquez, Marko Loncar, Benedikt Groever
  • Integrated circuits for neurotechnology and other applications
    Patent number: 11833346
    Abstract: The present invention generally relates to nanowires. In one aspect, the present invention is generally directed to systems and methods of individually addressing nanowires on a surface, e.g., that are substantially upstanding or vertically-oriented with respect to the surface. In some cases, one or more nanowires may be individually addressed using various integrated circuit (“IC”) technologies, such as CMOS. For example, the nanowires may form an array on top of an active CMOs integrated circuit.
    Type: Grant
    Filed: January 8, 2021
    Date of Patent: December 5, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: Hongkun Park, Donhee Ham, Jeffrey T. Abbott, Ling Qin, Marsela Jorgolli, Tianyang Ye
  • Compositions and methods for diagnosing, evaluating and treating cancer by means of the DNA methylation status
    Patent number: 11834718
    Abstract: The present invention relates to methods of determining a cancer treatment prognosis for a subject in need thereof by evaluating epigenetic and genetic changes within a tumor sample from the subject. The present invention further provides methods of treating cancer in a subject by evaluating epigenetic and genetic changes within a tumor sample from the subject. In addition, the present invention provides methods of screening test agents to identify agents that decrease tumor cell plasticity.
    Type: Grant
    Filed: September 10, 2020
    Date of Patent: December 5, 2023
    Assignees: The Broad Institute, Inc., Dana-Farber Cancer Institute, Inc., The General Hospital Corporation, President and Fellows of Harvard College
    Inventors: Mark Kendell Clement, Gad Getz, Dan-Avi Landau, Alexander Meissner, Catherine Ju-Ying Wu
  • METHODS AND COMPOSITIONS FOR PRIME EDITING NUCLEOTIDE SEQUENCES
    Publication number: 20230383289
    Abstract: Compositions and methods are provided herein for conducting prime editing of a target DNA molecule (e.g., a genome) that enables the incorporation of a nucleotide change and/or targeted mutagenesis. The compositions include fusion proteins comprising nucleic acid programmable DNA binding proteins (napDNAbp) and a polymerase (e.g., reverse transcriptase), which is guided to a specific DNA sequence by a modified guide RNA, named an PEgRNA. The PEgRNA has been altered (relative to a standard guide RNA) to comprise an extended portion that provides a DNA synthesis template sequence which encodes a single strand DNA flap which is synthesized by the polymerase of the fusion protein and which becomes incorporated into the target DNA molecule.
    Type: Application
    Filed: May 31, 2023
    Publication date: November 30, 2023
    Applicants: The Broad Institute, Inc., President and Fellows of Harvard College
    Inventors: David R. Liu, Andrew Vito Anzalone, James William Nelson
  • POLAR LIQUIDS WITH HIGH POROSITY AND USES THEREOF
    Publication number: 20230381739
    Abstract: To increase the gas solubility of polar liquids, the invention leverages coordination chemistry, nanoscience, and porous materials design to create porous liquids, e.g., aqueous solutions, containing a high density of networks of dry pores—which will feature dramatically higher capacities for dissolved gases than conventional polar liquids.
    Type: Application
    Filed: October 8, 2021
    Publication date: November 30, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: Jarad A. MASON, Malia B. WENNY, Daniel P. ERDOSY, Joy CHO, Christopher DELRE
  • METHODS FOR REGULATING BLOOD-CENTRAL NERVOUS SYSTEM (BLOOD-CNS) BARRIER AND USES THEREOF
    Publication number: 20230383295
    Abstract: The present disclosure, at least in part, provides methods for regulating Blood-Central Nervous System (blood-CNS) barrier permeability (e.g., increasing or decreasing Blood-CNS barrier permeability) by regulating signaling between pericyte derived vitronectin and integrin expressed on CNS endothelial cells (e.g., integrin ?5). In some aspects, the present disclosure also provides a Blood-Central Nervous System (blood-CNS) barrier model comprising CNS endothelial cells and vitronectin or a plurality of cells secreting vitronectin, and methods for producing the same.
    Type: Application
    Filed: April 5, 2023
    Publication date: November 30, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: Swathi Ayloo, Chenghua Gu
  • Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs)
    Patent number: 11827910
    Abstract: Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.
    Type: Grant
    Filed: February 5, 2021
    Date of Patent: November 28, 2023
    Assignees: President and Fellows of Harvard College, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Quan Lu, Qiyu Wang, Stanley N. Cohen
  • SC-beta cells and compositions and methods for generating the same
    Patent number: 11827905
    Abstract: Disclosed herein are methods, compositions, kits, and agents useful for inducing ? cell maturation, and isolated populations of SC-? cells for use in various applications, such as cell therapy.
    Type: Grant
    Filed: November 1, 2022
    Date of Patent: November 28, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: Quinn P. Peterson, Felicia J. Pagliuca, Douglas A. Melton, Jeffrey Robert Millman, Michael Saris Segel, Mads Gurtler
  • Antibody molecules to PD-1 and uses thereof
    Patent number: 11827704
    Abstract: Antibody molecules that specifically bind to PD-1 are disclosed. The anti-PD-1 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious conditions and disorders.
    Type: Grant
    Filed: July 10, 2020
    Date of Patent: November 28, 2023
    Assignees: Novartis AG, DANA-FARBER CANCER INSTITUTE, INC., PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Gordon James Freeman, Arlene Helen Sharpe, Walter A. Blattler, Jennifer Marie Mataraza, Catherine Anne Sabatos-Peyton, Hwai Wen Chang, Gerhard Johann Frey
  • OPTIMIZED CRISPR-CAS DOUBLE NICKASE SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION
    Publication number: 20230374550
    Abstract: The invention provides for delivery, engineering and optimization of systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in prokaryotic and eukaryotic cells to ensure enhanced specificity for target recognition and avoidance of toxicity.
    Type: Application
    Filed: February 6, 2023
    Publication date: November 23, 2023
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, President and Fellows of Harvard College
    Inventors: Feng ZHANG, Patrick HSU, Chie-yu LIN, Fei RAN
  • METHODS FOR MODULATING TLR4 SIGNALING
    Publication number: 20230372407
    Abstract: Provided herein are methods of use involving Bacteroides glycolipid compositions.
    Type: Application
    Filed: June 15, 2021
    Publication date: November 23, 2023
    Applicant: President and Fellows of Harvard College
    Inventors: Dennis L. Kasper, Kailyn L. Stefan
  • IMMUNOTHERAPEUTIC VIRUS FOR THE TREATMENT OF CANCER
    Publication number: 20230372472
    Abstract: Provided herein is a replication-defective oncolytic herpes simplex virus 1 (HSV-1) recombinant virus, comprising within its genome: a coding sequence encoding a fusion protein.
    Type: Application
    Filed: September 24, 2021
    Publication date: November 23, 2023
    Applicants: PRESIDENT AND FELLOWS OF HARVARD COLLEGE, DANA-FARBER CENTER INSTITUTE, INC.
    Inventors: David M. KNIPE, Michael J. WALSH, Stephanie K. DOUGAN
  • Detection of an antibody against a pathogen
    Patent number: 11821110
    Abstract: Provided herein are methods of detecting an antibody directed against a pathogen and uses thereof.
    Type: Grant
    Filed: July 8, 2020
    Date of Patent: November 21, 2023
    Assignees: The Brigham and Women's Hospital, Inc., President and Fellows of Harvard College
    Inventors: Stephen J. Elledge, Harry B. Larman, Tomasz Kula, George Xu