Abstract: Provided herein are methods and materials for diagnosing a subject's predisposition for pulmonary infection in a CF subject by detecting a pulmonary infection genetic marker. Pulmonary infection markers have been identified in the IL-1 gene cluster and may be useful in predicting CF disease progression and assessing a CF subject's response to therapy.
Type:
Grant
Filed:
November 15, 2011
Date of Patent:
September 15, 2015
Assignee:
Presidental and Fellows of Harvard College
Inventors:
Hara Levy, Craig Gerard, Gerald Pier, Scott Weiss, Christoph Lange