Abstract: A method and material for augmenting the shape and thickness of the cornea in situ includes applying a clear liquid collagen mixed with a customized crosslinker onto the augmentation surface or in a cavity (with or without a mold) and exposing the mixture to UVA radiation in vivo. Application of UVA at varying dosages demonstrate progressive optically clear gelation and biomechanical adherence properties, and in vitro optical properties (RI), mechanical suture strength and rheometric parameters are comparable to native corneal stromal tissue. Photochemical corneal collagen augmentation according to the invention makes it suitable to reconstruct and strengthen diseased and damaged eyes, ulcerated corneas, as well as provide a substrate for refractive onlay/inlay procedures and lamellar transplantation.

Abstract: Method and apparatus for performing oculoplasty including applying a photosensitizer solution to a human eye surface includes defining a treatment region within the human eye surface. The treatment region is associated with a predetermined spatial pattern. The method further includes irradiating the treatment region with controlled photoactivating radiation. In relation to presbyopia treatments, shrinkage of the paralimbal scleral region near the scleral spur results in improved near focus with no loss in far acuities.