Patents Assigned to Prime Synthesis, Inc.
  • Hybrid solid supports useful for oligonucleotide production
    Patent number: 9273087
    Abstract: A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within 1½ hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon.
    Type: Grant
    Filed: January 19, 2015
    Date of Patent: March 1, 2016
    Assignee: Prime Synthesis, Inc.
    Inventors: Marc L. Rothstein, Dianne M. Rothstein, Dan P. Lee
  • Hybrid solid supports comprising conformal crosslinked polymeric coating and useful for oligonucleotide production
    Patent number: 8956725
    Abstract: A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within 1½ hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon.
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: February 17, 2015
    Assignee: Prime Synthesis, Inc.
    Inventors: Marc L. Rothstein, Dianne M. Rothstein, Dan P. Lee
  • HYBRID SOLID SUPPORTS USEFUL FOR OLIGONUCLEOTIDE PRODUCTION
    Publication number: 20140087189
    Abstract: A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within 1½ hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon.
    Type: Application
    Filed: December 4, 2013
    Publication date: March 27, 2014
    Applicant: Prime Synthesis, Inc.
    Inventors: Marc L. Rothstein, Dianne M. Rothstein, Dan P. Lee
  • Hybrid solid supports useful for oligonucleotide production
    Patent number: 8628822
    Abstract: A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within 1½ hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon.
    Type: Grant
    Filed: June 24, 2008
    Date of Patent: January 14, 2014
    Assignee: Prime Synthesis, Inc.
    Inventors: Marc L Rothstein, Dianne M Rothstein, Dan P Lee
  • HYBRID SOLID SUPPORTS USEFUL FOR OLIGONUCLEOTIDE PRODUCTION
    Publication number: 20090005536
    Abstract: A method for preparing a crosslinked polymer coated controlled porosity glass (CPG) particle is provided. The method involves mixing CPG particles in a solution comprising polyvinylbenzylchloride and a first solvent at a temperature below 10° C. A second solvent is added and a crosslinking agent is added to the mixture. The first solvent is removed rapidly within 1½ hours of addition of the crosslinking agent. The crosslinking reaction is permitted to proceed and the mixture is then cooled and treated to remove any remaining solvent. The resulting coated CPG particles are washed and dried. Also provided a polymer coated CPG particles using for loading ligand thereon.
    Type: Application
    Filed: June 24, 2008
    Publication date: January 1, 2009
    Applicant: Prime Synthesis, Inc.
    Inventors: MARC L. ROTHSTEIN, Dianne M. Rothstein, Dan P. Lee