Patents Assigned to Primorigen Biosciences, Inc.
  • COMPOSITIONS AND METHODS FOR DIFFERENTIATING PLURIPOTENT STEM CELLS INTO PRIMITIVE BLOOD CELLS AND USES THEREOF
    Publication number: 20160369235
    Abstract: Compositions and methods that employ various combinations of such factors as retinoic acid signaling inhibitors, antioxidants, BMP4, VEGF, prostaglandin E2 pathway stimulants, TPO, SCF, FLT-3, EPO, TGF?1, p38 MAPK inhibitors, beta adrenergic receptor agonists, cell cycle inhibitors, RXR agonists, Cripto, and chromatin remodelers to drive differentiation of pluripotent stem cells towards primitive blood cells. Uses of such primitive blood cells are provided.
    Type: Application
    Filed: August 29, 2016
    Publication date: December 22, 2016
    Applicant: Primorigen Biosciences, Inc.
    Inventors: Niels-Bjarne Woods, Roger Ronn, Carolina Guibentif
  • Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof
    Patent number: 9428732
    Abstract: Compositions and methods that employ various combinations of such factors as retinoic acid signaling inhibitors, antioxidants, BMP4, VEGF, prostaglandin E2 pathway stimulants, TPO, SCF, FLT-3, EPO, TGF?1, p38 MAPK inhibitors, beta adrenergic receptor agonists, cell cycle inhibitors, RXR agonists, Cripto, and chromatin remodelers to drive differentiation of pluripotent stem cells towards primitive blood cells. Uses of such primitive blood cells are provided.
    Type: Grant
    Filed: December 5, 2012
    Date of Patent: August 30, 2016
    Assignee: Primorigen Biosciences, Inc.
    Inventors: Niels-Bjarne Woods, Roger Ronn, Carolina Guibentif