Patents Assigned to Princeton Biochemicals, Inc.
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Patent number: 11931741Abstract: Micro-valve system includes two or more superimposed tubes and a pressing device for fluid control in miniaturized capillary connections. The micro-valve system and method of fabrication can be tailored to the requirements of a wide range of applications; composition, sturdiness and thickness of plastic tubes; and capable of been adapted to the resilient of mechanical pressure and the passing and transport of fluid types.Type: GrantFiled: May 11, 2021Date of Patent: March 19, 2024Assignee: Princeton Biochemicals, IncInventors: Norberto Guzman, Daniel E. Guzman
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Patent number: 11740204Abstract: A diagnostic and prognostic method and system for sequentially analyzing in a biological fluid or tissue extract the presence of an antigenic infectious agent, infectious organism or its toxic product; an antibody response to the antigenic infectious agent, infectious organism or its toxic product; one or more biomarkers formed during infection in response to a communicable disease; and one or more biomarkers to assess the severity of the disease and to monitor the effectiveness of drug therapy or vaccination.Type: GrantFiled: February 16, 2022Date of Patent: August 29, 2023Assignee: PRINCETON BIOCHEMICALS INCInventor: Norberto A. Guzman
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Patent number: 11287396Abstract: A diagnostic and prognostic method and system for sequentially analyzing in a biological fluid or tissue extract the presence of an antigenic infectious agent, infectious organism or its toxic product; an antibody response to the antigenic infectious agent, infectious organism or its toxic product; one or more biomarkers formed during infection in response to a communicable disease; and one or more biomarkers to assess the severity of the disease and to monitor the effectiveness of drug therapy or vaccination.Type: GrantFiled: June 5, 2020Date of Patent: March 29, 2022Assignee: PRINCETON BIOCHEMICALS, INC.Inventor: Norberto A. Guzman
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Patent number: 11262330Abstract: An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest.Type: GrantFiled: July 2, 2019Date of Patent: March 1, 2022Assignee: PRINCETON BIOCHEMICALS, INC.Inventor: Norberto A. Guzman
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Patent number: 11198118Abstract: The present invention relates to an immunoaffinity device for capturing, isolating and purifying one or more analytes of interest present at high or low concentration in simple or complex matrices. The device is designed as an integrated modular unit that includes one or more analyte concentrator-microreactor devices anchored into a T-shaped support box, which is built-in or connected to a interchangeable cartridge-cassette of a capillary electrophoresis or liquid chromatography apparatus for the isolation, enrichment, derivatization, separation and characterization of small molecules and polymeric macromolecules, primarily protein and peptide biomarkers. The integrated modular unit is also designed to perform metabolic or bioactivity studies.Type: GrantFiled: March 28, 2018Date of Patent: December 14, 2021Assignee: PRINCETON BIOCHEMICALS, INC.Inventors: Norberto Guzman, Daniel E. Guzman
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Patent number: 10408789Abstract: An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest.Type: GrantFiled: September 28, 2015Date of Patent: September 10, 2019Assignee: PRINCETON BIOCHEMICALS, INC.Inventor: Norberto A. Guzman
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Patent number: 9482602Abstract: The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as an integrated modular unit and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers. The integrated modular unit includes an analyte-concentrator-microreaction device connected to a modified cartridge-cassette.Type: GrantFiled: April 22, 2014Date of Patent: November 1, 2016Assignee: PRINCETON BIOCHEMICALS, INC.Inventor: Norberto A. Guzman
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Patent number: 9146234Abstract: A disease detection system which includes an electrophoresis apparatus and a biomarker detector. The apparatus includes: (a) a transport passage; (b) a plurality of separation passages, each of the separation passages having an overlapping portion that overlaps the transport passage; and (c) a different biomarker concentrator in each of the overlapping portions and which concentrates at least one different biomarker from a specimen from an animal introduced into the transport passage. A plurality of the different biomarkers is associated with at least one predetermined disease, such as diabetes, heart disease or cancer. The detector detects the presence of the different biomarkers which were concentrated by the biomarker concentrators and delivered to the biomarker detector via the separation passages. First and second sets of the biomarker concentrators can be associated with respective first and second predetermined diseases and the user can determine which set will be used in each procedure.Type: GrantFiled: February 26, 2010Date of Patent: September 29, 2015Assignee: PRINCETON BIOCHEMICALS, INC.Inventor: Norberto A. Guzman
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Patent number: 8865075Abstract: The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as a modular, multi-task immunoaffinity device secured to a peripheral box and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers. In one embodiment, two devices are coupled in-tandem to perform separately and sequentially microreactions and concentrations of proteins. In this embodiment, biological samples containing proteins can be subjected to proteolytic processing in the first device, and the resulting peptides subjected to selective purification and concentration in the second device.Type: GrantFiled: October 28, 2011Date of Patent: October 21, 2014Assignee: Princeton Biochemicals, Inc.Inventor: Norberto A. Guzman
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Patent number: 8703061Abstract: The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as an integrated modular unit and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers. The integrated modular unit includes an analyte-concentrator-microreaction device connected to a modified cartridge-cassette.Type: GrantFiled: June 4, 2012Date of Patent: April 22, 2014Assignee: Princeton Biochemicals, Inc.Inventor: Norberto A. Guzman
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Patent number: 8268247Abstract: An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest.Type: GrantFiled: May 5, 2009Date of Patent: September 18, 2012Assignee: Princeton Biochemicals, Inc.Inventor: Norberto A. Guzman
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Patent number: 8182746Abstract: An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest.Type: GrantFiled: October 31, 2007Date of Patent: May 22, 2012Assignee: Princeton Biochemicals, Inc.Inventor: Norberto A. Guzman
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Patent number: 8030092Abstract: An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest.Type: GrantFiled: November 17, 2006Date of Patent: October 4, 2011Assignee: Princeton Biochemicals, Inc.Inventor: Norberto A. Guzman
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Patent number: 8007724Abstract: An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest.Type: GrantFiled: November 17, 2006Date of Patent: August 30, 2011Assignee: Princeton Biochemicals, Inc.Inventor: Norberto A. Guzman
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Patent number: 8007725Abstract: An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries and includes a valve system. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes. The apparatus may also include a plurality of valves surrounding each of the analyte concentrators to localize each of the concentrators to improve the binding of one or more analytes of interest.Type: GrantFiled: November 17, 2006Date of Patent: August 30, 2011Assignee: Princeton Biochemicals, Inc.Inventor: Norberto A. Guzman
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Patent number: 7811436Abstract: An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective inter-sections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes.Type: GrantFiled: October 31, 2007Date of Patent: October 12, 2010Assignee: Princeton Biochemicals, Inc.Inventor: Norberto A. Guzman
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Publication number: 20100213062Abstract: A disease detection system which includes an electrophoresis apparatus and a biomarker detector. The apparatus includes: (a) a transport passage; (b) a plurality of separation passages, each of the separation passages having an overlapping portion that overlaps the transport passage; and (c) a different biomarker concentrator in each of the overlapping portions and which concentrates at least one different biomarker from a specimen from an animal introduced into the transport passage. A plurality of the different biomarkers is associated with at least one predetermined disease, such as diabetes, heart disease or cancer. The detector detects the presence of the different biomarkers which were concentrated by the biomarker concentrators and delivered to the biomarker detector via the separation passages. First and second sets of the biomarker concentrators can be associated with respective first and second predetermined diseases and the user can determine which set will be used in each procedure.Type: ApplicationFiled: February 26, 2010Publication date: August 26, 2010Applicant: Princeton Biochemicals, Inc.Inventor: Norberto A. Guzman
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Patent number: 7736480Abstract: An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective intersections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes.Type: GrantFiled: January 24, 2006Date of Patent: June 15, 2010Assignee: Princeton Biochemicals, Inc.Inventor: Norberto A. Guzman
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Patent number: D857231Type: GrantFiled: March 30, 2016Date of Patent: August 20, 2019Assignee: PRINCETON BIOCHEMICALS, INC.Inventors: Norberto Guzman, Daniel E. Guzman
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Patent number: D923817Type: GrantFiled: July 1, 2019Date of Patent: June 29, 2021Assignee: PRINCETON BIOCHEMICALS, INCInventors: Norberto Guzman, Daniel E. Guzman