Patents Assigned to Prionics AG
  • Patent number: 10520506
    Abstract: Method for the detection and classification of PRRSV-infections in swine herds, comprising a) the incubation of tissue samples taken from the animals with at least one antigen capable to bind a neutralizing antibody against the Type I-virus possibly present in the animal and with at least one antigen capable to bind a neutralizing antibody against the Type II-virus possibly present in the animal, b) testing whether a binding of antibodies against the Type I-virus and/or the Type II-virus has taken place and c) determining from the presence of possible epitope-antibody complexes whether an infection of the PRRSV I-Type and/or PRRSV II-Type is present in the herd and diagnostic compositions for such a method.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: December 31, 2019
    Assignee: PRIONICS AG
    Inventors: Alex Raber, Franziska Baader Kuhn, Bjorn Schroder, Maria Frias Blanco
  • Patent number: 10285379
    Abstract: The present specification relates to apparatus, methods and kits for applying an identification tag to an animal and removing a tissue sample from the animal. Apparatus of the disclosure cannot be manipulated to transfer an identification tag from one animal to another. An apparatus can comprise a sample container, a flap, a downholder clip and a cutting element that can be placed on a male part of an ear-tag and at least one element/feature that supports movement of the sample container out of the movement path of the male tag toward the female part of the ear-tag.
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: May 14, 2019
    Assignee: PRIONICS AG
    Inventor: Alexander Berner
  • Patent number: 10272435
    Abstract: The present disclosure, according to one embodiment, describes a laboratory vessel for storing and treating a tissue sample comprises a closable opening, and additionally comprises a pipe part which is insertable in the opening of the laboratory vessel, wherein in inserted position, the pipe part seals against the laboratory vessel with its outer circumference and is clampingly displaceable with respect to said laboratory vessel, wherein a pestle is mounted in the laboratory vessel, over which the pipe part can be placed sealingly with its inner circumference. The laboratory vessel also comprises one or more tissue sample treatment agents. The tissue sample and the treatment agents are separated by placing the pipe part over the pestle, which separates a treatment agent region from a sample region.
    Type: Grant
    Filed: May 20, 2015
    Date of Patent: April 30, 2019
    Assignee: PRIONICS AG
    Inventor: Alexander Berner
  • Patent number: 9977022
    Abstract: Method for the detection and classification of PRRSV-infections in swine herds, comprising a) the incubation of tissue samples taken from the animals with at least one antigen capable to bind a neutralizing antibody against the Type I-virus possibly present in the animal and with at least one antigen capable to bind a neutralizing antibody against the Type II-virus possibly present in the animal, b) testing whether a binding of antibodies against the Type I-virus and/or the Type II-virus has taken place and c) determining from the presence of possible epitope-antibody complexes whether an infection of the PRRSV I-Type and/or PRRSV II-Type is present in the herd and diagnostic compositions for such a method.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: May 22, 2018
    Assignee: PRIONICS AG
    Inventors: Alex Räber, Franziska Baader Kuhn, Bjorn Schröder, Maria Frias Blanco
  • Patent number: 9804063
    Abstract: Sampling device for samples containing DNA in particular, with a sample-collecting area provided at the free end of an elongate holding device, wherein the sample-collecting area is designed to be separable from the sampling device.
    Type: Grant
    Filed: July 31, 2013
    Date of Patent: October 31, 2017
    Assignee: PRIONICS AG
    Inventors: Eligio Lardi, Christoph Stamm, Bernhard Hostettler, Mathias Blaser, Andreas Rüegg
  • Patent number: 8895021
    Abstract: Novel polynucleotide and amino acids of Brachyspira hyodysenteriae are described. These sequences are useful for diagnosis of B. hyodysenteriae disease in animals and as a therapeutic treatment or prophylactic treatment of B. hyodysenteriae disease in animals. These sequences may also be useful for diagnostic and therapeutic and/or prophylactic treatment of diseases in animals caused by other Brachyspira species.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: November 25, 2014
    Assignee: Prionics AG
    Inventors: David J. Hampson, Tom La, Matthew I. Bellgard, Nyree D. Phillips
  • Patent number: 8865422
    Abstract: A method for the diagnosis of a tuberculosis infection caused by Mycobacteria belonging to the Mycobacteria tuberculosis complex group (MTC) in an animal including a human being, which comprises in vitro-detection of cell-mediated immune response to OmpAtb and/or antibodies against OmpAtb in a sample taken from that animal.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: October 21, 2014
    Assignee: Prionics AG
    Inventors: Bruno Oesch, Irene Schiller, Martin Vordermeier
  • Publication number: 20130288389
    Abstract: Methods are disclosed for detecting prions and/or prion disease-associated forms of prion protein. These methods provide sensitive and specific identification of prions in both biological and environmental samples. These methods include the use of both immunoprecipitation and an amplification assay that uses shaking in the absence of sonication, such as QuIC(SQ) or RT-QuIC(RTQ). In specific non-limiting examples, the methods include the use of monoclonal antibody 15B3 and/or RT-QuIC(RTQ), and/or a substrate replacement step.
    Type: Application
    Filed: January 17, 2012
    Publication date: October 31, 2013
    Applicants: Prionics AG, THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human
    Inventors: Christina D. Orru, Byron W. Caughey, Franziska Kuhn, Bjorn Schroder, Alex Raeber
  • Patent number: 8512962
    Abstract: The present invention relates to the method for treatment of tissue samples with proteolytic/histolytic additive collagenase or other similar protease prior to testing with an antigen capture immunoassay to identify cattle infected with Bovine Viral Diarrhea Virus (BVDV). The use of collagenase or other similar protease in antigen extraction step of the assay drastically increases accuracy of the assay, thus it allows for a more effective, reliable, quick, and cost effective way of identifying and thereby removing infected cattle and/or other animals from an otherwise uninfected herd.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: August 20, 2013
    Assignee: Prionics AG
    Inventor: Miladin Kostovic
  • Patent number: 8465932
    Abstract: Method for the determination of Trichinella infections in an animal or a human, comprising the incubation with Trichinella antigens of a tissue sample taken from the animal or the human, the processing of the tissue sample, the addition of anti-antibodies to the tissue sample, and the verification of whether binding of the anti-antibodies to any antigen/antibody complexes present in the tissue sample has taken place, where the anti-antibodies added are anti-IgG antibodies and simultaneously anti-IgM antibodies.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: June 18, 2013
    Assignee: Prionics AG
    Inventors: Alex Raber, Tina Haupt, Patrik Buholzer
  • Patent number: 8460681
    Abstract: Novel polynucleotide and amino acids of Brachyspira hyodysenteriae are described. These sequences are useful for diagnosis of B. hyodysenteriae disease in animals and as a therapeutic treatment or prophylactic treatment of B. hyodysenteriae disease in animals. These sequences may also be useful for diagnostic and therapeutic and/or prophylactic treatment of diseases in animals caused by other Brachyspira species.
    Type: Grant
    Filed: March 26, 2009
    Date of Patent: June 11, 2013
    Assignee: Prionics AG
    Inventors: David J. Hampson, Tom La, Matthew I. Bellgard, Nyree D. Phillips
  • Publication number: 20130102491
    Abstract: A method for the diagnosis of a tuberculosis infection caused by Mycobacteria belonging to the Mycobacteria tuberculosis complex group (MTC) in an animal including a human being, which comprises in vitro-detection of cell-mediated immune response to OmpAtb and/or antibodies against OmpAtb in a sample taken from that animal.
    Type: Application
    Filed: December 18, 2012
    Publication date: April 25, 2013
    Applicant: PRIONICS AG
    Inventor: Prionics AG
  • Patent number: 8361416
    Abstract: The invention relates to a sample container (10, 100, 500, 700) for biological sample material (23, 230), comprising an upper opening (11) that can be closed by a lid (14, 140, 540), a lateral wall region (12) and a base (13) and a hygroscopic substance (19, 190, 590, 790) contained in the interior of the sample container for drying sample material (23, 230) in the sample container, wherein the sample container is partitioned into at least two compartments, of which one is a sample compartment (16, 160, 560), and the other is a drying compartment (18, 180, 580) containing the hygroscopic substance, wherein the hygroscopic substance is connected to the interior of the sample container in a steam exchange connection, and wherein the sample compartment extends from an upper end, particularly equipped with an opening (40, 400), in the longitudinal direction to the opening in a flush manner to the base (13) of the sample container.
    Type: Grant
    Filed: January 22, 2009
    Date of Patent: January 29, 2013
    Assignee: Prionics AG
    Inventors: Alexander Berner, Bernhard Hostettler
  • Patent number: 8048637
    Abstract: A diagnostic composition to detect antibodies in a sample obtained from an animal or human being infected by Trichinella, comprising at least one peptide containing a series of amino acids that form a continuous or discontinuous epitope recognized by sera from pigs infected with Trichinella.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: November 1, 2011
    Assignee: Prionics AG
    Inventors: Patrik Buholzer, Alex Raber, Paul Price, Daniel Zwald, Weldy Bonilla Pinschewer, Roger Marti, Jurg Weidmann, Christoph Stamm
  • Patent number: 7980500
    Abstract: An apparatus for cutting up biological sample material, including a sample container, a rotary drive device separate from the sample container, and a shaft rotatably arranged in the sample container, wherein the shaft has a laterally projecting cutting device in the region of a working end and has a coupling piece in the region of a coupling end, said coupling piece being accessible from outside and being designed for coupling engagement with a coupling counterpart of the rotary drive device, wherein the shaft (14) is arranged with lateral guidance and in an axially displaceable manner in the sample container (10), the coupling piece (19) and the coupling counterpart (21) are designed for producing coupling engagement which is positive-locking in the direction of rotation (23) and permits an axial displacement, and the cutting device (16) is designed in a propeller shape in such a way that, during rotation of the shaft (14) in the working direction, it exerts a propulsive force on the latter in the direction
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: July 19, 2011
    Assignee: Prionics AG
    Inventors: Stefan Jenni, Daniel Krieg, Karsten Meissner
  • Publication number: 20110127177
    Abstract: Container for receiving lab samples, whereby the samples are held in the container at a distance from the internal wall and in a defined height range, and whereby a drying device is provided inside the container at least in said height range and surrounds the sample on the side, at least partially, and includes a drying agent, and is constructed such that gas exchange between sample and drying agent is feasible.
    Type: Application
    Filed: July 28, 2009
    Publication date: June 2, 2011
    Applicant: PRIONICS AG
    Inventors: Bernhard Hostettler, Brigitta Kipfer-Schafer, Christoph Stamm
  • Publication number: 20110033871
    Abstract: Method for the determination of Trichinella infections in an animal or a human, comprising the incubation with Trichinella antigens of a tissue sample taken from the animal or the human, the processing of the tissue sample, the addition of anti-antibodies to the tissue sample, and the verification of whether binding of the anti-antibodies to any antigen/antibody complexes present in the tissue sample has taken place, where the anti-antibodies added are anti-IgG antibodies and simultaneously anti-IgM antibodies.
    Type: Application
    Filed: June 16, 2009
    Publication date: February 10, 2011
    Applicant: PRIONICS AG
    Inventors: Alex Raber, Tina Haupt, Patrik Buholzer
  • Publication number: 20100291662
    Abstract: The invention relates to a sample container (10, 100, 500, 700) for biological sample material (23, 230), comprising an upper opening (11) that can be closed by a lid (14, 140, 540), a lateral wall region (12) and a base (13) and a hygroscopic substance (19, 190, 590, 790) contained in the interior of the sample container for drying sample material (23, 230) in the sample container, wherein the sample container is partitioned into at least two compartments, of which one is a sample compartment (16, 160, 560), and the other is a drying compartment (18, 180, 580) containing the hygroscopic substance, wherein the hygroscopic substance is connected to the interior of the sample container in a steam exchange connection, and wherein the sample compartment extends from an upper end, particularly equipped with an opening (40, 400), in the longitudinal direction to the opening in a flush manner to the base (13) of the sample container.
    Type: Application
    Filed: January 22, 2009
    Publication date: November 18, 2010
    Applicant: PRIONICS AG
    Inventors: Alexander Berner, Bernhard Hostettler
  • Publication number: 20100240026
    Abstract: The present invention relates to the method for treatment of tissue samples with proteolytic/histolytic additive collagenase or other similar protease prior to testing with an antigen capture immunoassay to identify cattle infected with Bovine Viral Diarrhea Virus (BVDV). The use of collagenase or other similar protease in antigen extraction step of the assay drastically increases accuracy of the assay, thus it allows for a more effective, reliable, quick, and cost effective way of identifying and thereby removing infected cattle and/or other animals from an otherwise uninfected herd.
    Type: Application
    Filed: December 3, 2008
    Publication date: September 23, 2010
    Applicant: PRIONICS AG
    Inventor: Miladin Kostovic
  • Patent number: D729942
    Type: Grant
    Filed: December 4, 2013
    Date of Patent: May 19, 2015
    Assignee: PRIONICS AG
    Inventors: Gerrit Dirk Keizer, Wilhelmus Joseph Gerardus Schielen