Patents Assigned to Prionics AG
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Patent number: 10520506Abstract: Method for the detection and classification of PRRSV-infections in swine herds, comprising a) the incubation of tissue samples taken from the animals with at least one antigen capable to bind a neutralizing antibody against the Type I-virus possibly present in the animal and with at least one antigen capable to bind a neutralizing antibody against the Type II-virus possibly present in the animal, b) testing whether a binding of antibodies against the Type I-virus and/or the Type II-virus has taken place and c) determining from the presence of possible epitope-antibody complexes whether an infection of the PRRSV I-Type and/or PRRSV II-Type is present in the herd and diagnostic compositions for such a method.Type: GrantFiled: May 3, 2018Date of Patent: December 31, 2019Assignee: PRIONICS AGInventors: Alex Raber, Franziska Baader Kuhn, Bjorn Schroder, Maria Frias Blanco
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Patent number: 10285379Abstract: The present specification relates to apparatus, methods and kits for applying an identification tag to an animal and removing a tissue sample from the animal. Apparatus of the disclosure cannot be manipulated to transfer an identification tag from one animal to another. An apparatus can comprise a sample container, a flap, a downholder clip and a cutting element that can be placed on a male part of an ear-tag and at least one element/feature that supports movement of the sample container out of the movement path of the male tag toward the female part of the ear-tag.Type: GrantFiled: December 28, 2015Date of Patent: May 14, 2019Assignee: PRIONICS AGInventor: Alexander Berner
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Patent number: 10272435Abstract: The present disclosure, according to one embodiment, describes a laboratory vessel for storing and treating a tissue sample comprises a closable opening, and additionally comprises a pipe part which is insertable in the opening of the laboratory vessel, wherein in inserted position, the pipe part seals against the laboratory vessel with its outer circumference and is clampingly displaceable with respect to said laboratory vessel, wherein a pestle is mounted in the laboratory vessel, over which the pipe part can be placed sealingly with its inner circumference. The laboratory vessel also comprises one or more tissue sample treatment agents. The tissue sample and the treatment agents are separated by placing the pipe part over the pestle, which separates a treatment agent region from a sample region.Type: GrantFiled: May 20, 2015Date of Patent: April 30, 2019Assignee: PRIONICS AGInventor: Alexander Berner
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Patent number: 9977022Abstract: Method for the detection and classification of PRRSV-infections in swine herds, comprising a) the incubation of tissue samples taken from the animals with at least one antigen capable to bind a neutralizing antibody against the Type I-virus possibly present in the animal and with at least one antigen capable to bind a neutralizing antibody against the Type II-virus possibly present in the animal, b) testing whether a binding of antibodies against the Type I-virus and/or the Type II-virus has taken place and c) determining from the presence of possible epitope-antibody complexes whether an infection of the PRRSV I-Type and/or PRRSV II-Type is present in the herd and diagnostic compositions for such a method.Type: GrantFiled: May 14, 2014Date of Patent: May 22, 2018Assignee: PRIONICS AGInventors: Alex Räber, Franziska Baader Kuhn, Bjorn Schröder, Maria Frias Blanco
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Patent number: 9804063Abstract: Sampling device for samples containing DNA in particular, with a sample-collecting area provided at the free end of an elongate holding device, wherein the sample-collecting area is designed to be separable from the sampling device.Type: GrantFiled: July 31, 2013Date of Patent: October 31, 2017Assignee: PRIONICS AGInventors: Eligio Lardi, Christoph Stamm, Bernhard Hostettler, Mathias Blaser, Andreas Rüegg
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Patent number: 8895021Abstract: Novel polynucleotide and amino acids of Brachyspira hyodysenteriae are described. These sequences are useful for diagnosis of B. hyodysenteriae disease in animals and as a therapeutic treatment or prophylactic treatment of B. hyodysenteriae disease in animals. These sequences may also be useful for diagnostic and therapeutic and/or prophylactic treatment of diseases in animals caused by other Brachyspira species.Type: GrantFiled: June 10, 2013Date of Patent: November 25, 2014Assignee: Prionics AGInventors: David J. Hampson, Tom La, Matthew I. Bellgard, Nyree D. Phillips
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Patent number: 8865422Abstract: A method for the diagnosis of a tuberculosis infection caused by Mycobacteria belonging to the Mycobacteria tuberculosis complex group (MTC) in an animal including a human being, which comprises in vitro-detection of cell-mediated immune response to OmpAtb and/or antibodies against OmpAtb in a sample taken from that animal.Type: GrantFiled: December 18, 2012Date of Patent: October 21, 2014Assignee: Prionics AGInventors: Bruno Oesch, Irene Schiller, Martin Vordermeier
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Publication number: 20130288389Abstract: Methods are disclosed for detecting prions and/or prion disease-associated forms of prion protein. These methods provide sensitive and specific identification of prions in both biological and environmental samples. These methods include the use of both immunoprecipitation and an amplification assay that uses shaking in the absence of sonication, such as QuIC(SQ) or RT-QuIC(RTQ). In specific non-limiting examples, the methods include the use of monoclonal antibody 15B3 and/or RT-QuIC(RTQ), and/or a substrate replacement step.Type: ApplicationFiled: January 17, 2012Publication date: October 31, 2013Applicants: Prionics AG, THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and HumanInventors: Christina D. Orru, Byron W. Caughey, Franziska Kuhn, Bjorn Schroder, Alex Raeber
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Patent number: 8512962Abstract: The present invention relates to the method for treatment of tissue samples with proteolytic/histolytic additive collagenase or other similar protease prior to testing with an antigen capture immunoassay to identify cattle infected with Bovine Viral Diarrhea Virus (BVDV). The use of collagenase or other similar protease in antigen extraction step of the assay drastically increases accuracy of the assay, thus it allows for a more effective, reliable, quick, and cost effective way of identifying and thereby removing infected cattle and/or other animals from an otherwise uninfected herd.Type: GrantFiled: December 3, 2008Date of Patent: August 20, 2013Assignee: Prionics AGInventor: Miladin Kostovic
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Patent number: 8465932Abstract: Method for the determination of Trichinella infections in an animal or a human, comprising the incubation with Trichinella antigens of a tissue sample taken from the animal or the human, the processing of the tissue sample, the addition of anti-antibodies to the tissue sample, and the verification of whether binding of the anti-antibodies to any antigen/antibody complexes present in the tissue sample has taken place, where the anti-antibodies added are anti-IgG antibodies and simultaneously anti-IgM antibodies.Type: GrantFiled: June 16, 2009Date of Patent: June 18, 2013Assignee: Prionics AGInventors: Alex Raber, Tina Haupt, Patrik Buholzer
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Patent number: 8460681Abstract: Novel polynucleotide and amino acids of Brachyspira hyodysenteriae are described. These sequences are useful for diagnosis of B. hyodysenteriae disease in animals and as a therapeutic treatment or prophylactic treatment of B. hyodysenteriae disease in animals. These sequences may also be useful for diagnostic and therapeutic and/or prophylactic treatment of diseases in animals caused by other Brachyspira species.Type: GrantFiled: March 26, 2009Date of Patent: June 11, 2013Assignee: Prionics AGInventors: David J. Hampson, Tom La, Matthew I. Bellgard, Nyree D. Phillips
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Publication number: 20130102491Abstract: A method for the diagnosis of a tuberculosis infection caused by Mycobacteria belonging to the Mycobacteria tuberculosis complex group (MTC) in an animal including a human being, which comprises in vitro-detection of cell-mediated immune response to OmpAtb and/or antibodies against OmpAtb in a sample taken from that animal.Type: ApplicationFiled: December 18, 2012Publication date: April 25, 2013Applicant: PRIONICS AGInventor: Prionics AG
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Patent number: 8361416Abstract: The invention relates to a sample container (10, 100, 500, 700) for biological sample material (23, 230), comprising an upper opening (11) that can be closed by a lid (14, 140, 540), a lateral wall region (12) and a base (13) and a hygroscopic substance (19, 190, 590, 790) contained in the interior of the sample container for drying sample material (23, 230) in the sample container, wherein the sample container is partitioned into at least two compartments, of which one is a sample compartment (16, 160, 560), and the other is a drying compartment (18, 180, 580) containing the hygroscopic substance, wherein the hygroscopic substance is connected to the interior of the sample container in a steam exchange connection, and wherein the sample compartment extends from an upper end, particularly equipped with an opening (40, 400), in the longitudinal direction to the opening in a flush manner to the base (13) of the sample container.Type: GrantFiled: January 22, 2009Date of Patent: January 29, 2013Assignee: Prionics AGInventors: Alexander Berner, Bernhard Hostettler
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Patent number: 8048637Abstract: A diagnostic composition to detect antibodies in a sample obtained from an animal or human being infected by Trichinella, comprising at least one peptide containing a series of amino acids that form a continuous or discontinuous epitope recognized by sera from pigs infected with Trichinella.Type: GrantFiled: June 29, 2007Date of Patent: November 1, 2011Assignee: Prionics AGInventors: Patrik Buholzer, Alex Raber, Paul Price, Daniel Zwald, Weldy Bonilla Pinschewer, Roger Marti, Jurg Weidmann, Christoph Stamm
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Patent number: 7980500Abstract: An apparatus for cutting up biological sample material, including a sample container, a rotary drive device separate from the sample container, and a shaft rotatably arranged in the sample container, wherein the shaft has a laterally projecting cutting device in the region of a working end and has a coupling piece in the region of a coupling end, said coupling piece being accessible from outside and being designed for coupling engagement with a coupling counterpart of the rotary drive device, wherein the shaft (14) is arranged with lateral guidance and in an axially displaceable manner in the sample container (10), the coupling piece (19) and the coupling counterpart (21) are designed for producing coupling engagement which is positive-locking in the direction of rotation (23) and permits an axial displacement, and the cutting device (16) is designed in a propeller shape in such a way that, during rotation of the shaft (14) in the working direction, it exerts a propulsive force on the latter in the directionType: GrantFiled: August 25, 2006Date of Patent: July 19, 2011Assignee: Prionics AGInventors: Stefan Jenni, Daniel Krieg, Karsten Meissner
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Publication number: 20110127177Abstract: Container for receiving lab samples, whereby the samples are held in the container at a distance from the internal wall and in a defined height range, and whereby a drying device is provided inside the container at least in said height range and surrounds the sample on the side, at least partially, and includes a drying agent, and is constructed such that gas exchange between sample and drying agent is feasible.Type: ApplicationFiled: July 28, 2009Publication date: June 2, 2011Applicant: PRIONICS AGInventors: Bernhard Hostettler, Brigitta Kipfer-Schafer, Christoph Stamm
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Publication number: 20110033871Abstract: Method for the determination of Trichinella infections in an animal or a human, comprising the incubation with Trichinella antigens of a tissue sample taken from the animal or the human, the processing of the tissue sample, the addition of anti-antibodies to the tissue sample, and the verification of whether binding of the anti-antibodies to any antigen/antibody complexes present in the tissue sample has taken place, where the anti-antibodies added are anti-IgG antibodies and simultaneously anti-IgM antibodies.Type: ApplicationFiled: June 16, 2009Publication date: February 10, 2011Applicant: PRIONICS AGInventors: Alex Raber, Tina Haupt, Patrik Buholzer
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Publication number: 20100291662Abstract: The invention relates to a sample container (10, 100, 500, 700) for biological sample material (23, 230), comprising an upper opening (11) that can be closed by a lid (14, 140, 540), a lateral wall region (12) and a base (13) and a hygroscopic substance (19, 190, 590, 790) contained in the interior of the sample container for drying sample material (23, 230) in the sample container, wherein the sample container is partitioned into at least two compartments, of which one is a sample compartment (16, 160, 560), and the other is a drying compartment (18, 180, 580) containing the hygroscopic substance, wherein the hygroscopic substance is connected to the interior of the sample container in a steam exchange connection, and wherein the sample compartment extends from an upper end, particularly equipped with an opening (40, 400), in the longitudinal direction to the opening in a flush manner to the base (13) of the sample container.Type: ApplicationFiled: January 22, 2009Publication date: November 18, 2010Applicant: PRIONICS AGInventors: Alexander Berner, Bernhard Hostettler
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Publication number: 20100240026Abstract: The present invention relates to the method for treatment of tissue samples with proteolytic/histolytic additive collagenase or other similar protease prior to testing with an antigen capture immunoassay to identify cattle infected with Bovine Viral Diarrhea Virus (BVDV). The use of collagenase or other similar protease in antigen extraction step of the assay drastically increases accuracy of the assay, thus it allows for a more effective, reliable, quick, and cost effective way of identifying and thereby removing infected cattle and/or other animals from an otherwise uninfected herd.Type: ApplicationFiled: December 3, 2008Publication date: September 23, 2010Applicant: PRIONICS AGInventor: Miladin Kostovic
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Patent number: D729942Type: GrantFiled: December 4, 2013Date of Patent: May 19, 2015Assignee: PRIONICS AGInventors: Gerrit Dirk Keizer, Wilhelmus Joseph Gerardus Schielen