Abstract: Personal communication devices and computer-implemented systems for monitoring of ALS disease state of a patient are presented. The computer-implemented system comprises assignment selection module configured to access a library comprising predefined activity(ies), and enable selection of at least one predefined activity to be monitored by sensor(s) associated with the patient; assignment execution module configured to identify sensing signal(s) from the sensor(s) and generate corresponding output signal(s) indicative of the predefined activity, the sensing signal(s) comprising at least one of the following: reading, drawing, finger tapping, speaking, breathing, walking; and assignment reporting module configured to communicate with a data analyzer for communicating the output signal(s) indicative of the predefined activity to the data analyzer, thereby enabling storing the output data in a memory for use in monitoring and analyzing the ALS disease state of the patient.