Patents Assigned to Pro-Neuron, Inc.
  • Compositions and methods for treatment of mitochondrial diseases
    Publication number: 20070010479
    Abstract: Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidine nucleotide precursors in amounts sufficient to treat symptoms resulting from mitochondrial respiratory chain deficiencies.
    Type: Application
    Filed: September 14, 2006
    Publication date: January 11, 2007
    Applicant: Pro-Neuron, Inc.
    Inventor: Reid von Borstel
  • Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
    Publication number: 20040235782
    Abstract: The invention relates to certain oxypurine nucleosides, congeners of such oxypurine nucleosides, and acyl derivatives thereof, and compositions which contain at least one of these compounds. The invention also relates to methods of treating or preventing hematopoietic disorders and modifying hematopoiesis, and treating or preventing inflammatory diseases and bacterial infections by administering a compound or composition of the present invention to an animal.
    Type: Application
    Filed: June 25, 2004
    Publication date: November 25, 2004
    Applicant: Pro-Neuron, Inc.
    Inventors: Reid W. von Borstel, Michael K. Bamat, Bradley M. Hiltbrand, James C. Butler, Shyam Shirali
  • Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
    Publication number: 20040220134
    Abstract: Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
    Type: Application
    Filed: May 28, 2004
    Publication date: November 4, 2004
    Applicant: Pro-Neuron, Inc.
    Inventors: Reid W. von Borstel, Michael K. Bamat, Bradley M. Hiltbrand
  • Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
    Publication number: 20040033981
    Abstract: Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
    Type: Application
    Filed: June 24, 2003
    Publication date: February 19, 2004
    Applicant: Pro-Neuron Inc.
    Inventors: Reid W. von Borstel, Michael K. Bamat, Bradley M. Hiltbrand
  • Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory heptitis
    Publication number: 20030212036
    Abstract: Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
    Type: Application
    Filed: April 24, 2003
    Publication date: November 13, 2003
    Applicant: Pro Neuron, Inc.
    Inventors: Reid W. von Borstel, Michael K. Bamat, Bradley M. Hiltbrand
  • Inhibitor of stem cell proliferation and uses thereof
    Publication number: 20030104984
    Abstract: Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation.
    Type: Application
    Filed: April 24, 2002
    Publication date: June 5, 2003
    Applicant: Pro-Neuron Inc.
    Inventors: Irena Tsyrlova, Stephen D. Wolpe
  • Compositions and methods for treatment of mitochondrial diseases
    Patent number: 6472378
    Abstract: Compounds, compositions, and methods are provided for treatment of disorders related to mitochondrial dysfunction. The methods comprise administering to a mammal a composition containing pyrimidine nucleotide precursors in amounts sufficient to treat symptoms resulting from mitochondrial respiratory chain deficiencies.
    Type: Grant
    Filed: August 31, 1998
    Date of Patent: October 29, 2002
    Assignee: Pro-Neuron, Inc.
    Inventor: Reid W. von Borstel
  • Inhibitor of stem cell proliferation and uses thereof
    Patent number: 6432917
    Abstract: Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 13, 2002
    Assignee: Pro-Neuron, Inc.
    Inventors: Vladimir Kozlov, Irena Tsyrlova
  • Inhibitor of stem cell proliferation and uses thereof
    Publication number: 20020098583
    Abstract: Disclosed and claimed are methods for the isolation and use of stem cell inhibiting factors for regulating the abnormal stem cell cycle and for accelerating the post-chemotherapy peripheral blood cell recovery. Also disclosed and claimed are the inhibitors of stem cell proliferation.
    Type: Application
    Filed: April 23, 2001
    Publication date: July 25, 2002
    Applicant: Pro-Neuron, Inc.
    Inventors: Vladimir Kozlov, Irena Tsyrlova
  • Antimutagenic compositions for treatment and prevention of photodamage to skin
    Patent number: 6417170
    Abstract: A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in concentrations sufficient to enhance DNA repair or reduce mutation frequency in a vehicle capable of delivering effective amounts of deoxyribonucleosides to the necessary skin cells.
    Type: Grant
    Filed: June 4, 2001
    Date of Patent: July 9, 2002
    Assignee: Pro-Neuron, Inc.
    Inventors: Reid W. von Borstel, Fedor Romantsev
  • Antimutagenic compositions for treatment and prevention of photodamage to skin
    Patent number: 6403565
    Abstract: A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in concentrations sufficient to enhance DNA repair or reduce mutation frequency in a vehicle capable of delivering effective amounts of deoxyribonucleosides to the necessary skin cells.
    Type: Grant
    Filed: September 1, 1999
    Date of Patent: June 11, 2002
    Assignee: Pro-Neuron, Inc.
    Inventors: Reid W. von Borstel, Fedor Romantsev
  • Acylated uridine and cytidine and uses thereof
    Publication number: 20020035086
    Abstract: The invention relates to compositions comprising acyl derivatives of cytidine and uridine. The invention also relates to methods of treating hepatopathies, diabetes, heart disease, cerebrovascular disorders, Parkinson's disease, infant respiratory distress syndrome and for enhancement of phospholipid biosynthesis comprising administering the acyl derivatives of the invention to an animal.
    Type: Application
    Filed: September 28, 2001
    Publication date: March 21, 2002
    Applicant: Pro Neuron, Inc.
    Inventors: Reid Warren von Borstel, Michael Kevin Bamat
  • Acyl deoxyribonucleoside derivatives and uses thereof
    Patent number: 6348451
    Abstract: The invention relates to compositions comprising acyl derivatives of 2′-deoxyribonucleosides. The invention also relates to methods of treating or preventing radiation, mutagen and sunlight-induced biological damage, and methods for improving wound healing and tissue repair, comprising administering the compositions of the present invention to an animal.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: February 19, 2002
    Assignee: Pro-Neuron, Inc.
    Inventors: Reid Warren von Borstel, Michael Kevin Bamat
  • Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides
    Patent number: 6344447
    Abstract: The subject invention discloses compounds, compositions and methods for treatment and prevention of toxicity due to chemotherapeutic agents and antiviral agents. Disclosed are acylated derivatives of non-methylated pyrimidine nucleosides. These compounds are capable of attenuating damage to the hematopoietic system in animals receiving antiviral or antineoplastic chemotherapy.
    Type: Grant
    Filed: February 16, 1999
    Date of Patent: February 5, 2002
    Assignee: Pro-Neuron, Inc.
    Inventors: Reid W. von Borstel, Michael K. Bamat
  • Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
    Patent number: 6329350
    Abstract: Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: December 11, 2001
    Assignee: Pro-Neuron, Inc.
    Inventors: Reid W. von Borstel, Michael K. Bamat, Bradley M. Hiltbrand
  • Antimutagenic compositions for treatment and prevention of photodamage to skin
    Publication number: 20010044421
    Abstract: A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in concentrations sufficient to enhance DNA repair or reduce mutation frequency in a vehicle capable of delivering effective amounts of deoxyribonucleosides to the necessary skin cells.
    Type: Application
    Filed: June 4, 2001
    Publication date: November 22, 2001
    Applicant: Pro-Neuron, Inc.
    Inventors: Reid W. von Borstel, Fedor Romantsev
  • Antimutagenic compositions for treatment and prevention of photodamage to skin
    Publication number: 20010044419
    Abstract: A method of improving DNA repair and reducing DNA damage and for reducing mutation frequency in skin for the purpose of reducing consequences of exposure to solar or ultraviolet radiation is disclosed. The methods comprise administering to the skin a composition containing deoxyribonucleosides in concentrations sufficient to enhance DNA repair or reduce mutation frequency in a vehicle capable of delivering effective amounts of deoxyribonucleosides to the necessary skin cells.
    Type: Application
    Filed: June 4, 2001
    Publication date: November 22, 2001
    Applicant: Pro-Neuron, Inc.
    Inventors: Reid W. von Borstel, Fedor Romantsev
  • Acylated uridine and cytidine and uses thereof
    Patent number: 6316426
    Abstract: The invention relates to compositions comprising acyl derivatives of cytidine and uridine. The invention also relates to methods of treating hepatopathies, diabetes, heart disease, cerebrovascular disorders, Parkinson's disease, infant respiratory distress syndrome and for enhancement of phospholipid biosynthesis comprising administering the acyl derivatives of the invention to an animal.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 13, 2001
    Assignee: Pro-Neuron, Inc.
    Inventors: Reid Warren von Borstel, Michael Kevin Bamat
  • Acyl deoxyribonucleoside derivatives and uses thereof
    Patent number: 6306834
    Abstract: The invention relates to compositions comprising acyl derivatives of 2′-deoxyribonucleosides. The invention also relates to methods of treating or preventing radiation, mutagen and sunlight-induced biological damage, and methods for improving wound healing and tissue repair, comprising administering the compositions of the present invention to an animal.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: October 23, 2001
    Assignee: Pro-Neuron, Inc.
    Inventors: Reid Warren von Borstel, Michael Kevin Bamat
  • Acyl deoxyribonucleoside derivatives and uses thereof
    Patent number: 6297222
    Abstract: The invention relates to compositions comprising acyl derivatives of 2′-deoxyribonucleosides. The invention also relates to methods of treating or preventing radiation, mutagen and sunlight-induced biological damage, and methods for improving wound healing and tissue repair, comprising administering the compositions of the present invention to an animal.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 2, 2001
    Assignee: Pro-Neuron, Inc.
    Inventors: Reid Warren von Borstel, Michael Kevin Bamat