Abstract: Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The methods comprise providing a whole (unfractionated) saliva sample from a subject; contacting an aliquot of the saliva with two or more lectins under conditions that allow the two or more lectins to bind to a lectin-binding component of the saliva; detecting the amount of bound lectin; and comparing the amount of bound lectin to the amount known to bind a saliva sample from a control patient, to predict the risk of a disease in the subject. Also provided are methods for reducing the risk of a disease and a method for assessing the risk of the disease at a defined level.
Type:
Application
Filed:
April 24, 2012
Publication date:
October 18, 2012
Applicants:
UNIVERSITY OF SOUTHERN CALIFORNIA, PROACTIVE ORAL SOLUTIONS, INC.
Inventors:
Patricia Denny, Paul C. Denny, Mahvash Navazesh
Abstract: Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The methods comprise providing a whole (unfractionated) saliva sample from a subject; contacting an aliquot of the saliva with two or more lectins under conditions that allow the two or more lectins to bind to a lectin-binding component of the saliva; detecting the amount of bound lectin; and comparing the amount of bound lectin to the amount known to bind a saliva sample from a control patient, to predict the risk of a disease in the subject. Also provided are methods for reducing the risk of a disease and a method for assessing the risk of the disease at a defined level.
Type:
Grant
Filed:
May 24, 2010
Date of Patent:
April 24, 2012
Assignees:
Proactive Oral Solutions, Inc., University of Southern California
Inventors:
Patricia Denny, Paul C. Denny, Mahvash Navazesh
Abstract: Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The methods comprise providing a whole (unfractionated) saliva sample from a subject; contacting an aliquot of the saliva with two or more lectins under conditions that allow the two or more lectins to bind to a lectin-binding component of the saliva; detecting the amount of bound lectin; and comparing the amount of bound lectin to the amount known to bind a saliva sample from a control patient, to predict the risk of a disease in the subject. Also provided are methods for reducing the risk of a disease and a method for assessing the risk of the disease at a defined level.
Type:
Grant
Filed:
April 1, 2004
Date of Patent:
June 15, 2010
Assignees:
Proactive Oral Solutions, Inc., University of Southern California
Inventors:
Patricia Denny, Paul C. Denny, Mahvash Navazesh
Abstract: Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The method comprises providing a whole (unfractionated) saliva sample from a subject; contacting an aliquot of said saliva with one or more lectins under conditions that allow said one or more lectins to bind to a lectin-binding component of said saliva; detecting the amount of bound lectin; and comparing the amount of bound lectin to the amount known to bind a saliva sample from a control patient, to predict the risk of a disease in the subject. Also provided are methods for reducing the risk of a disease and a method for assessing the risk of the disease at a defined level.
Type:
Application
Filed:
April 1, 2004
Publication date:
November 23, 2006
Applicant:
Proactive Oral Solutions, Inc.
Inventors:
Patricia Denny, Paul Denny, Mahvash Navazesh