Patents Assigned to Probelte Pharma, S.A.
  • Patent number: 9155708
    Abstract: An orally administrable immunostimulant product comprises a microencapsulated cytokine and an enteric protection polymer to protect the cytokine, the cytokine is a fish, mollusc or crustacean cytokine, preferably a recombinant cytokine such as tumor necrosis factor ? (TNF?) over-expressed in a host microorganism.
    Type: Grant
    Filed: October 10, 2008
    Date of Patent: October 13, 2015
    Assignee: PROBELTE PHARMA, S.A.
    Inventors: Sergio A. Streitenberger, Marcos Peñalver Mellado, José A. López Más, Yolanda Pedreño López, Juan P. Sola González, Pedro Martínez Ortiz, Victoriano Mulero Mendez, Francisco Roca Soler, Jorge Galindo Villegas
  • Patent number: 8968811
    Abstract: Hydroxytyrosol extracted from olives and/or from the solid residues of olives after the extraction of olive oil, by acid hydrolysis and purification on resin columns eluted with water contains hydroxytyrosol and tyrosol, is free from sugars, has a residual content of Benzo[a]pyrene that is less than 2 microg/Kg (weight BaP/weight of extract as dry matter), containing a weight ratio of hydroxytyrosol to hydroxymethylfurfural of between 45:1 and 10000:1, and the content of hydroxytyrosol in the extract is at least 0.5% (w/w) with purity of at least 40% (by HPLC 280 nm).
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: March 3, 2015
    Assignee: Probelte Pharma, S.A.
    Inventors: Jose A. Lopez Mas, Sergio A. Streitenberger, Marcos Peñ{tilde over ( )}alver Mellado, Pedro Martinez Ortiz
  • Publication number: 20130178537
    Abstract: Hydroxytyrosol extracted from olives and/or from the solid residues of olives after the extraction of olive oil, by acid hydrolysis and purification on resin columns eluted with water contains hydroxytyrosol and tyrosol, is free from sugars, has a residual content of Benzo[a]pyrene that is less than 2 microg/Kg (weight BaP/weight of extract as dry matter), containing a weight ratio of hydroxytyrosol to hydroxymethylfurfural of between 45:1 and 10000:1, and the content of hydroxytyrosol in the extract is at least 0.5% (w/w) with purity of at least 40% (by HPLC 280 nm).
    Type: Application
    Filed: July 6, 2012
    Publication date: July 11, 2013
    Applicant: Probelte Pharma, S.A.
    Inventors: Jose A. Lopez Mas, Sergio A. Streitenberger, Marcos Penalver Mellado, Pedro Martinez Ortiz
  • Patent number: 8236993
    Abstract: Hydroxytyrosol is extracted from olives and/or from the solid residues of olives after the extraction of olive oil, by carrying out acid hydrolysis at a temperature within the range of 110° C. to 140° C. and at a pH within the range of 1.0 to 6.0, and by purifying the obtained solution on a column containing acid activated anion exchange resins, and a column containing an adsorbent non-ionic resin; both columns being eluted with water to recover the hydroxytyrosol.
    Type: Grant
    Filed: January 25, 2008
    Date of Patent: August 7, 2012
    Assignee: Probelte Pharma, S.A.
    Inventors: José A. López Más, Sergio A. Streitenberger, Marcos Peñalver Mellado, Pedro Martinez Ortiz
  • Publication number: 20110225660
    Abstract: An orally administrable immunostimulant product comprises a microencapsulated cytokine and an enteric protection polymer to protect the cytokine, the cytokine is a fish, mollusc or crustacean cytokine, preferably a recombinant cytokine such as tumor necrosis factor ? (TNF?) over-expressed in a host microorganism.
    Type: Application
    Filed: October 10, 2008
    Publication date: September 15, 2011
    Applicant: PROBELTE PHARMA, S.A.
    Inventors: Sergio A. Streitenberger, Marcos Peñalver Mellado, José A. López Más, Yolanda Pedreño López, Juan P. Sola González, Pedro Martínez Ortiz, Victoriano Mulero Mendez, Francisco Roca Soler, Jorge Galindo Villegas
  • Publication number: 20100210586
    Abstract: The present invention relates to new pomegranate extracts, combined or not with soluble fiber, compositions free of any kind of organic solvent, soluble in cold water in high concentration, with very low sugar content and specially standardized to punicalagins, and its addition to foods to provide nutritional products and beverages with increased antioxidant capacity to be used as a source of punicalagins for preventing or treating cardiovascular diseases, plaque build-up in the arteries, arterial hypertension, and metabolic syndrome.
    Type: Application
    Filed: September 5, 2008
    Publication date: August 19, 2010
    Applicant: PROBELTE PHARMA, S.A.
    Inventors: Jose A. Lopez Mas, Sergio A. Streitenberger, Marcos Penalver Mellado, Yolanda Pedreno Lopez, Pedro Martinez Ortiz