Abstract: An orally administrable immunostimulant product comprises a microencapsulated cytokine and an enteric protection polymer to protect the cytokine, the cytokine is a fish, mollusc or crustacean cytokine, preferably a recombinant cytokine such as tumor necrosis factor ? (TNF?) over-expressed in a host microorganism.
Type:
Grant
Filed:
October 10, 2008
Date of Patent:
October 13, 2015
Assignee:
PROBELTE PHARMA, S.A.
Inventors:
Sergio A. Streitenberger, Marcos Peñalver Mellado, José A. López Más, Yolanda Pedreño López, Juan P. Sola González, Pedro Martínez Ortiz, Victoriano Mulero Mendez, Francisco Roca Soler, Jorge Galindo Villegas
Abstract: Hydroxytyrosol extracted from olives and/or from the solid residues of olives after the extraction of olive oil, by acid hydrolysis and purification on resin columns eluted with water contains hydroxytyrosol and tyrosol, is free from sugars, has a residual content of Benzo[a]pyrene that is less than 2 microg/Kg (weight BaP/weight of extract as dry matter), containing a weight ratio of hydroxytyrosol to hydroxymethylfurfural of between 45:1 and 10000:1, and the content of hydroxytyrosol in the extract is at least 0.5% (w/w) with purity of at least 40% (by HPLC 280 nm).
Type:
Grant
Filed:
July 6, 2012
Date of Patent:
March 3, 2015
Assignee:
Probelte Pharma, S.A.
Inventors:
Jose A. Lopez Mas, Sergio A. Streitenberger, Marcos Peñ{tilde over ( )}alver Mellado, Pedro Martinez Ortiz
Abstract: Hydroxytyrosol extracted from olives and/or from the solid residues of olives after the extraction of olive oil, by acid hydrolysis and purification on resin columns eluted with water contains hydroxytyrosol and tyrosol, is free from sugars, has a residual content of Benzo[a]pyrene that is less than 2 microg/Kg (weight BaP/weight of extract as dry matter), containing a weight ratio of hydroxytyrosol to hydroxymethylfurfural of between 45:1 and 10000:1, and the content of hydroxytyrosol in the extract is at least 0.5% (w/w) with purity of at least 40% (by HPLC 280 nm).
Type:
Application
Filed:
July 6, 2012
Publication date:
July 11, 2013
Applicant:
Probelte Pharma, S.A.
Inventors:
Jose A. Lopez Mas, Sergio A. Streitenberger, Marcos Penalver Mellado, Pedro Martinez Ortiz
Abstract: Hydroxytyrosol is extracted from olives and/or from the solid residues of olives after the extraction of olive oil, by carrying out acid hydrolysis at a temperature within the range of 110° C. to 140° C. and at a pH within the range of 1.0 to 6.0, and by purifying the obtained solution on a column containing acid activated anion exchange resins, and a column containing an adsorbent non-ionic resin; both columns being eluted with water to recover the hydroxytyrosol.
Type:
Grant
Filed:
January 25, 2008
Date of Patent:
August 7, 2012
Assignee:
Probelte Pharma, S.A.
Inventors:
José A. López Más, Sergio A. Streitenberger, Marcos Peñalver Mellado, Pedro Martinez Ortiz
Abstract: An orally administrable immunostimulant product comprises a microencapsulated cytokine and an enteric protection polymer to protect the cytokine, the cytokine is a fish, mollusc or crustacean cytokine, preferably a recombinant cytokine such as tumor necrosis factor ? (TNF?) over-expressed in a host microorganism.
Type:
Application
Filed:
October 10, 2008
Publication date:
September 15, 2011
Applicant:
PROBELTE PHARMA, S.A.
Inventors:
Sergio A. Streitenberger, Marcos Peñalver Mellado, José A. López Más, Yolanda Pedreño López, Juan P. Sola González, Pedro Martínez Ortiz, Victoriano Mulero Mendez, Francisco Roca Soler, Jorge Galindo Villegas
Abstract: The present invention relates to new pomegranate extracts, combined or not with soluble fiber, compositions free of any kind of organic solvent, soluble in cold water in high concentration, with very low sugar content and specially standardized to punicalagins, and its addition to foods to provide nutritional products and beverages with increased antioxidant capacity to be used as a source of punicalagins for preventing or treating cardiovascular diseases, plaque build-up in the arteries, arterial hypertension, and metabolic syndrome.
Type:
Application
Filed:
September 5, 2008
Publication date:
August 19, 2010
Applicant:
PROBELTE PHARMA, S.A.
Inventors:
Jose A. Lopez Mas, Sergio A. Streitenberger, Marcos Penalver Mellado, Yolanda Pedreno Lopez, Pedro Martinez Ortiz