Abstract: An assay method for detecting the presence or amounts of VCAM-1 and A2M in a sample using fluorescence resonance energy transfer (FRET).

Abstract: An assay method for detecting the presence or amounts of VCAM-1 and A2M in a sample using fluorescence resonance energy transfer (FRET).

Abstract: The disclosure provides fluorescence resonance energy transfer (FRET) assays to detect the presence of anti-TNF? biologics and/or their autoantibodies in a patient sample to monitor TNF? inhibitor therapy and to guide treatment decisions.

Abstract: An assay method for detecting the presence or amounts of VCAM-1 and A2M in a sample using fluorescence resonance energy transfer (FRET).

Abstract: The present disclosure provides solution based assays for detecting antibodies induced by SARS-CoV-2 (anti-SARS-CoV-2) in a biological sample.

Abstract: Methods and compositions are disclosed for preparing a predetermined standardized calibration curve, which can be stored on a label, barcode or tag. A lyophilized product containing assay reagents for use in a bioassay and a known amount of analyte. A predetermined calibration curve associated with the lyophilized product. A predetermined calibration curve makes the preparation of a new calibration curve unnecessary. The methods and compositions are useful in bioassays such as a FRET assay, a real-time reverse transcription polymerase (RT-PCR) assay, a chemiluminescence assay, or any other bioassay that elicits a detectable response based on a change in, or appearance of, color, fluorescence, or reflectance.

Abstract: The present disclosure provides assay methods to detect and measure proteins in order to distinguish between a bacterial infection and a viral infection.

Abstract: Provided herein are methods for accommodating for sample matrix effects in light measurement assays. A selected amount of a light emitting material is added to a sample, and the light output from the sample is measured. By using an algorithm based on the known light emitting material amount and the measured light output, a correction factor for the assay of the sample is determined. The correction factor can be used to adjust subsequent light output measurements of other samples recorded using the assay.

Abstract: An assay method for detecting the presence or amount of human serum albumin vitamin D, C-reactive protein, or anti-transglutaminase autoantibody (ATA) immunoglobulin A (IgA) and/or ATA IgG in a sample using fluorescence resonance energy transfer (FRET).

Abstract: An assay method for detecting and measuring the presence or amount of glycated hemoglobin in a sample using fluorescence resonance energy transfer (FRET).

Abstract: Assay methods for detecting the presence or amount of VCAM-1 or calprotectin in a sample using fluorescence resonance energy transfer (FRET).

Abstract: Provided herein are containers for holding a portion of a biological sample such as a fecal sample. The containers include a body that can be sealed with an upper cap that is attached to a sampling pin and a grip member. The sampling pin is configured to collect a predetermined amount of sample in one or more sampling grooves, with excess sample amount optionally removed from the sampling pin by an interior flange of the container body. The grip member is configured to provide the user of the container with improved torque and grip, and to distance the fingers of the user from the sample being collected. Also provided are kits and methods including the disclosed containers.

Abstract: Provided herein are analyzers as well as related methods for measuring both an absorbance and emission of a sample. The analyzer includes light sources for epi-illumination and transillumination of the sample, and detectors for measuring the intensities of excitation, emission, and transillumination light. A dichroic mirror permits a portion of the excitation light to transmit to a detector that monitors changes in excitation light intensity. Temperature sensors allow for signal corrections based on temperature variations of the detectors and sample.