Patents Assigned to Procognia LTD
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Publication number: 20120277116Abstract: Disclosed is a method for characterizing carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer is allowed to contact the substrate under conditions that allow for formation of a first complex between the first saccharide-binding agent and the carbohydrate polymer. In one aspect, the method is used in the diagnosis of a disease, including a viral disease, an autoimmune disease, a bacterial infection, or cancer.Type: ApplicationFiled: July 10, 2012Publication date: November 1, 2012Applicant: Procognia, Ltd.Inventors: Ofer Markman, Assaf (Assaph) Peretz Oron, Chana Rothmann-Schertz
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Patent number: 8119357Abstract: The invention relates generally the structural analysis of glycomolecule-containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides.Type: GrantFiled: September 30, 2010Date of Patent: February 21, 2012Assignee: Procognia, Ltd.Inventors: Yehudit Amor, Ofer Markman, Mirit Kolog Gulko, Albena Samokovlisky, Fredi Kleinman, Tal Alergand, Rakefet Rosenfeld, Ruth Maya, Sabina Rebe, Idil Kelson Kasuto, Haim Bangio
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Publication number: 20110071041Abstract: Disclosed is a method for characterizing carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer is allowed to contact the substrate under conditions that allow for formation of a first complex between the first saccharide-binding agent and the carbohydrate polymer. A second saccharide-binding agent, which preferably includes a label, is also contacted with the carbohydrate polymer under conditions that allow for formation of a second complex between the second binding agent and the first complex. Identification of the first and second binding agent allows for characterization of the polysaccharide.Type: ApplicationFiled: August 4, 2010Publication date: March 24, 2011Applicant: Procognia,Ltd.Inventors: Ofer Markman, Assaf (Assaph) Peretz Oron, Chana Rothmann-Schertz
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Publication number: 20110021376Abstract: The invention relates generally the structural analysis of glycomolecule-containing macromolecules, such as those that occur either attached to proteins (proteoglycans, glycoproteins), lipids, or as free saccharides.Type: ApplicationFiled: September 30, 2010Publication date: January 27, 2011Applicant: Procognia, Ltd.Inventors: Yehudit Amor, Ofer Markman, Mirit Kolog Gulko, Albena Samokovlisky, Fredi Kleinman, Tal Alergand, Rakefet Rosenfeld, Ruth Maya, Sabina Rebe, Idil Kelson Kasuto, Haim Bangio
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Patent number: 7741061Abstract: The invention provides a method for the structural analysis of a saccharide, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) washing or otherwise removing unbound saccharide or saccharide fragments; d) adding to the surface obtained in step c) an essentially sequence- and/or site-specific marker, or a mixture of essentially sequence- and/or site-specific markers; e) acquiring one or more images of the markers that are bound to said surface; and f) deriving information related to the identity of the saccharide being analyzed from said image.Type: GrantFiled: November 12, 2008Date of Patent: June 22, 2010Assignee: Procognia Ltd.Inventor: Ofer Markman
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Patent number: 7455979Abstract: The invention provides a method for the structural analysis of a saccharide, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) washing or otherwise removing unbound saccharide or saccharide fragments; d) adding to the surface obtained in step c) an essentially sequence- and/or site-specific marker, or a mixture of essentially sequence- and/or site-specific markers; e) acquiring one or more images of the markers that are bound to said surface; and f) deriving information related to the identity of the saccharide being analyzed from said image.Type: GrantFiled: April 12, 2006Date of Patent: November 25, 2008Assignee: Procognia Ltd.Inventor: Ofer Markman
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Patent number: 7407773Abstract: Disclosed is a method for characterizing carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer is allowed to contact the substrate under conditions that allow for formation of a first complex between the first saccharide-binding agent and the carbohydrate polymer. A second saccharide-binding agent, which preferably includes a label, is also contacted with the carbohydrate polymer under conditions that allow for formation of a second complex between the second binding agent and the first complex. Identification of the first and second binding agent allows for characterization of the polysaccharide.Type: GrantFiled: April 11, 2006Date of Patent: August 5, 2008Assignee: Procognia, Ltd.Inventors: Ofer Markman, Assaf (Assaph) Peretz Oron, Chana Rothmann-Schertz
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Patent number: 7132251Abstract: Disclosed is a method for characterizing a carbohydrate polymer by identifying at least two binding agents that bind to the carbohydrate polymer. Binding is preferably determined by contacting the carbohydrate polymer with substrate that contains a plurality of first saccharide-binding agents affixed at predetermined locations on the substrate. The carbohydrate polymer is allowed to contact the substrate under conditions that allow for formation of a first complex between the first saccharide-binding agent and the carbohydrate polymer. A second saccharide-binding agent, which preferably includes a label, is also contacted with the carbohydrate polymer under conditions that allow for formation of a second complex between the second binding agent and the first complex. Identification of the first and second binding agent allows for characterization of the polysaccharide.Type: GrantFiled: November 3, 2000Date of Patent: November 7, 2006Assignee: Procognia LtdInventors: Ofer Markman, Assaf (Assaph) Peretz Oron, Chana Rothemann-Schertz
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Patent number: 7079955Abstract: A system and method for characterizing carbohydrate polymers according to maps obtained from experimental data. Preferably, the data is obtained from a plurality of different types of experimental assays for characterizing the carbohydrate polymer. More preferably, at least one such assay involves binding a saccharide-binding agent to the carbohydrate polymer. One or more features of the carbohydrate polymer are then preferably characterized. These features are preferably derived from maps of the data obtained from assays involving the sample carbohydrate polymer. These maps are more preferably analyzed at a plurality of levels, with each level providing more abstract biological information. Most preferably, new types of experimental data are introduced to the process of analysis at each level, in order to support more complex analyses of the data. Optionally and most preferably, maps are eliminated at each level as being inconsistent with the experimental data.Type: GrantFiled: November 5, 2001Date of Patent: July 18, 2006Assignee: Procognia, Ltd.Inventors: Assaf Peretz Oron, Einat Or, Ofer Markman, Leonid Shvartser, Nava Zaarur
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Patent number: 7056678Abstract: The invention provides a method for the structural analysis of a saccharide, comprising: a) providing on a surface a plurality of essentially sequence- and/or site-specific binding agents; b) contacting said surface with a saccharide to be analyzed, or with a mixture comprising a plurality of fragments of said saccharide; c) washing or otherwise removing unbound saccharide or saccharide fragments; d) adding to the surface obtained in step c) an essentially sequence- and/or site-specific marker, or a mixture of essentially sequence- and/or site-specific markers; e) acquiring one or more images of the markers that are bound to said surface; and f) deriving information related to the identity of the saccharide being analyzed from said image.Type: GrantFiled: May 4, 2000Date of Patent: June 6, 2006Assignee: Procognia LTDInventor: Ofer Markman