Patents Assigned to PROCOM ONE, INC.
  • Low-Dose Doxepin For Treatment Of Sleep Disorders In Elderly Patients
    Publication number: 20220151975
    Abstract: Methods of treating sleep disorders, particularly certain aspects of insomnia, in elderly patients (65 years and older) by administering initial daily dosages of doxepin of 1-3 mg. These ultra-low initial dosages are more effective in elderly versus non-elderly patients in decreasing wake time during sleep, latency to persistent sleep and wake time after sleep, and are particularly efficacious in treating those conditions in the last hour of an 8-hour sleep cycle. Also, the dosages described herein are safe for elderly individuals.
    Type: Application
    Filed: January 31, 2022
    Publication date: May 19, 2022
    Applicants: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Roberta L. Rogowski, Susan Ellen Dube, Philip Jochelson, Neil B. Kavey
  • COMBINATION THERAPY USING LOW-DOSE DOXEPIN FOR THE IMPROVEMENT OF SLEEP
    Publication number: 20210283094
    Abstract: A composition comprising doxepin, or a pharmaceutically acceptable salt, or prodrug thereof, and a compound that enhances sleep onset, sleep maintenance or reduces early morning awakenings. These compositions are useful for treating multiple manifestations of insomnia.
    Type: Application
    Filed: May 24, 2021
    Publication date: September 16, 2021
    Applicants: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Philip Jochelson, Robert Mansbach, Michael Skinner, Neil B. Kavey
  • Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 11007168
    Abstract: The invention relates to use of the trans-(E) isomer or isomeric mixtures containing specified ratios of the trans-(E) and cis-(Z) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: May 18, 2021
    Assignees: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey
  • Methods Of Using Low-Dose Doxepin For The Improvement Of Sleep
    Publication number: 20200345680
    Abstract: Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
    Type: Application
    Filed: May 18, 2020
    Publication date: November 5, 2020
    Applicants: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Roberta L. Rogowski, Susan E. Dubé, Philip Jochelson, Neil B. Kavey
  • Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 10758510
    Abstract: The invention relates to use of the cis-(Z) isomer or isomeric mixtures containing specified ratios of the cis-(Z) and trans-(E) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders
    Type: Grant
    Filed: April 8, 2019
    Date of Patent: September 1, 2020
    Assignees: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey
  • Methods of using low-dose doxepin for the improvement of sleep
    Patent number: 10653662
    Abstract: Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
    Type: Grant
    Filed: March 25, 2019
    Date of Patent: May 19, 2020
    Assignees: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Roberta L. Rogowski, Susan E. Dubé, Philip Jochelson, Neil B. Kavey
  • Ultra low dose doxepin and methods of using the same to treat sleep disorders
    Patent number: 10507193
    Abstract: The invention relates to doxepin, pharmaceutically acceptable salts and prodrugs of doxepin; compositions containing the same, and the use of any of the aforementioned for the treatment of sleep disorders.
    Type: Grant
    Filed: March 5, 2018
    Date of Patent: December 17, 2019
    Assignees: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Philip Jochelson, Neil B. Kavey
  • Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 10493053
    Abstract: The invention relates to use of the trans-(E) isomer or isomeric mixtures containing specified ratios of the trans-(E) and cis-(Z) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders.
    Type: Grant
    Filed: December 3, 2018
    Date of Patent: December 3, 2019
    Assignees: Currax Pharmaceuticals LLC, ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey
  • Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 10251859
    Abstract: The invention relates to use of the cis-(Z) isomer or isomeric mixtures containing specified ratios of the cis-(Z) and trans-(E) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders.
    Type: Grant
    Filed: October 30, 2017
    Date of Patent: April 9, 2019
    Assignees: Pernix Sleep, Inc., ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey
  • Methods of using low-dose doxepin for the improvement of sleep
    Patent number: 10238620
    Abstract: Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: March 26, 2019
    Assignees: Pernix Sleep, Inc., ProCom One, Inc.
    Inventors: Roberta L. Rogowski, Susan E. Dubé, Philip Jochelson, Neil B. Kavey
  • Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 10143676
    Abstract: The invention relates to use of the trans-(E) isomer or isomeric mixtures containing specified ratios of the trans-(E) and cis-(Z) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: December 4, 2018
    Assignees: Pernix Sleep, Inc., ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey
  • Ultra low dose doxepin and methods of using the same to treat sleep disorders
    Patent number: 9907779
    Abstract: The invention relates to doxepin, pharmaceutically acceptable salts and prodrugs of doxepin; compositions containing the same, and the use of any of the aforementioned for the treatment of sleep disorders.
    Type: Grant
    Filed: October 3, 2013
    Date of Patent: March 6, 2018
    Assignees: Pernix Sleep, Inc., ProCom One, Inc.
    Inventors: Philip Jochelson, Neil B. Kavey
  • Methods of using low-dose doxepin for the improvement of sleep
    Patent number: 9861607
    Abstract: Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: January 9, 2018
    Assignees: Procom One, Inc., Pernix Sleep, Inc.
    Inventors: Roberta L. Rogowski, Susan E. Dubé, Philip Jochelson, Neil B. Kavey
  • Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 9801847
    Abstract: The invention relates to use of the cis-(Z) isomer or isomeric mixtures containing specified ratios of the cis-(Z) and trans-(E) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders.
    Type: Grant
    Filed: October 10, 2016
    Date of Patent: October 31, 2017
    Assignees: Pernix Sleep, Inc., ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey
  • Doxepin trans isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 9498462
    Abstract: The invention relates to use of the trans-(E) isomer or isomeric mixtures containing specified ratios of the trans-(E) and cis-(Z) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: November 22, 2016
    Assignees: Pernix Sleep, Inc., ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey
  • Methods of using low-dose doxepin for the improvement of sleep
    Patent number: 9486437
    Abstract: Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
    Type: Grant
    Filed: July 21, 2015
    Date of Patent: November 8, 2016
    Assignees: Pernix Sleep, Inc., ProCom One, Inc.
    Inventors: Roberta L. Rogowski, Susan E. Dubé, Philip Jochelson, Neil B. Kavey
  • Doxepin isomers and isomeric mixtures and methods of using the same to treat sleep disorders
    Patent number: 9463181
    Abstract: The invention relates to use of the cis-(Z) isomer or isomeric mixtures containing specified ratios of the cis-(Z) and trans-(E) isomers of doxepin, metabolites of doxepin, pharmaceutically-acceptable salts of doxepin and prodrugs of the same; compositions containing the same, for the treatment of sleep disorders.
    Type: Grant
    Filed: December 3, 2012
    Date of Patent: October 11, 2016
    Assignees: Pemix Sleep, Inc., ProCom One, Inc.
    Inventors: Susan E. Dubé, Neil B. Kavey
  • ULTRA LOW DOSE DOXEPIN AND METHODS OF USING THE SAME TO TREAT SLEEP DISORDERS
    Publication number: 20140107084
    Abstract: The invention relates to doxepin, pharmaceutically acceptable salts and prodrugs of doxepin; compositions containing the same, and the use of any of the aforementioned for the treatment of sleep disorders.
    Type: Application
    Filed: October 3, 2013
    Publication date: April 17, 2014
    Applicants: ProCom One, Inc., Somaxon Pharmaceuticals, Inc.
    Inventors: Philip Jochelson, Neil B. Kavey
  • LOW-DOSE DOXEPIN FOR TREATMENT OF SLEEP DISORDERS IN ELDERLY PATIENTS
    Publication number: 20140051750
    Abstract: Methods of treating sleep disorders, particularly certain aspects of insomnia, in elderly patients (65 years and older) by administering initial daily dosages of doxepin of 1-3 mg. These ultra-low initial dosages are more effective in elderly versus non-elderly patients in decreasing wake time during sleep, latency to persistent sleep and wake time after sleep, and are particularly efficacious in treating those conditions in the last hour of an 8-hour sleep cycle. Also, the dosages described herein are safe for elderly individuals.
    Type: Application
    Filed: August 16, 2013
    Publication date: February 20, 2014
    Applicants: PROCOM ONE, INC., SAMAXON PHARMACEUTICALS, INC.
    Inventors: Roberta L. Rogowski, Susan Ellen Dubé, Philip Jochelson, Neil Barton Kavey
  • Methods of using low-dose doxepin for the improvement of sleep
    Patent number: 8513299
    Abstract: Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: August 20, 2013
    Assignees: Pernix Sleep, Inc., Procom One, Inc.
    Inventors: Roberta L. Rogowski, Susan E. Dubé, Philip Jochelson