Abstract: The present invention is directed to a two-handed tube squeezer for facilitating the expulsion of material from a collapsible container. In one embodiment, the tube squeezer includes a pair of frames that each has a handle portion and a tube engagement portion that supports a roller. The frames are connected by a hinge. When the frames are substantially parallel to one another, the handle and tube engagement portions all lie in a low profile plane. The handle portions also form a handle that is separated from the tube engagement portions. When a user is holding the handle with one hand and causing the rollers to squeeze a tube with the other hand, the hand that is holding the handle is separated from the tube engagement portions such that the squeezed portion of the tube is unlikely to come in contact with the hand that is gripping the handle.