Patents Assigned to Profibrix B.V.
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Patent number: 9205240Abstract: A device for the topical dispensing of a powder, typically a powder medicament, comprises, or is adapted to be coupled to, a powder receptacle and a gasflow generator. The gasflow generator is adapted, in use, to cause gas to flow through the device, which further comprises an agitator by which the powder and/or the powder receptacle can be mechanically agitated. Actuation of the gasflow generator, which causes gas to flow through the device and to entrain powder from the powder receptacle, thereby to dispense powder from the device, is accompanied by actuation of the agitator, causing the powder receptacle to be mechanically agitated, thereby facilitating the release of powder from the powder receptacle.Type: GrantFiled: December 15, 2009Date of Patent: December 8, 2015Assignee: PROFIBRIX B.V.Inventors: Paul Greenhalgh, Joseph Maria Grimbergen, Oliver Harvey
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Patent number: 9119897Abstract: A fibrin sealant comprises a mixture of first microparticles that comprise fibrinogen, second microparticles that comprise thrombin, and additive material. The additive material may be particulate, and may be, for instance, a biocompatible, water-absorbent, material, a biocompatible, water-swellable material, a biocompatible, water-insoluble material, a polysaccharide or silica.Type: GrantFiled: May 28, 2010Date of Patent: September 1, 2015Assignee: PROFIBRIX B.V.Inventors: Glen Patrick Martyn, Jacob Koopman
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Patent number: 9089584Abstract: Dry powder compositions are useful in the treatment or prevention of tissue adhesions during or after surgery or during wound therapy. The dry powder compositions may contain trehalose. The dry powder compositions may be fibrin sealant compositions comprising fibrinogen and/or thrombin.Type: GrantFiled: May 28, 2010Date of Patent: July 28, 2015Assignee: PROFIBRIX B.V.Inventor: Jacob Koopman
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Patent number: 8846105Abstract: The present invention relates to a dry powder fibrin sealant which comprises a mixture of fibrinogen and thrombin for use in surgery, trauma and other wounds or injuries. It further relates to novel formulations comprising said dry powder fibrin sealant for use in the treatment of wounds or for surgical intervention or as a topical hemostat.Type: GrantFiled: January 7, 2011Date of Patent: September 30, 2014Assignee: Profibrix, B.V.Inventors: Jacob Koopman, Glen Martyn
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Publication number: 20130274690Abstract: Provided is a device for the dispensing of powders of the type in which a generated gas flow entrains the powder to be dispensed and carries the powder from the device via a barrel. The barrel has a bore including a main portion with a continuous internal surface, and is characterized in that the length of the main portion is at least fifteen times its maximum internal diameter; and/or the internal bore of the main portion is tapered; and/or the barrel has an outwardly flared outlet portion.Type: ApplicationFiled: December 23, 2011Publication date: October 17, 2013Applicant: PROFIBRIX B.V.Inventors: Paul Greenhalgh, Eliane Schutte
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Publication number: 20120070477Abstract: A fibrin sealant comprises a mixture of first microparticles that comprise fibrinogen, second microparticles that comprise thrombin, and additive material. The additive material may be particulate, and may be, for instance, a biocompatible, water-absorbent, material, a biocompatible, water-swellable material, a biocompatible, water-insoluble material, a polysaccharide or silica.Type: ApplicationFiled: May 28, 2010Publication date: March 22, 2012Applicant: PROFIBRIX B.V.Inventors: Glen Patrick Martyn, Jacob Koopman
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Publication number: 20120064165Abstract: Dry powder compositions are useful in the treatment or prevention of tissue adhesions during or after surgery or during wound therapy. The dry powder compositions may contain trehalose. The dry powder compositions may be fibrin sealant compositions comprising fibrinogen and/or thrombin.Type: ApplicationFiled: May 28, 2010Publication date: March 15, 2012Applicant: PROFIBRIX B.V.Inventor: Jacob Koopman
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Publication number: 20120016465Abstract: The present invention relates to extravascular supports. In particular, to extravascular supports which are used in vein grafting. More in particular, it relates to extravascular supports which are biodegradable.Type: ApplicationFiled: February 5, 2010Publication date: January 19, 2012Applicant: PROFIBRIX, B.V.Inventor: Jacob Laurens Koopman
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Publication number: 20110251580Abstract: A device for the topical dispensing of a powder, typically a powder medicament, comprises, or is adapted to be coupled to, a powder receptacle and a gasflow generator. The gasflow generator is adapted, in use, to cause gas to flow through the device, which further comprises an agitator by which the powder and/or the powder receptacle can be mechanically agitated. Actuation of the gasflow generator, which causes gas to flow through the device and to entrain powder from the powder receptacle, thereby to dispense powder from the device, is accompanied by actuation of the agitator, causing the powder receptacle to be mechanically agitated, thereby facilitating the release of powder from the powder receptacle.Type: ApplicationFiled: December 15, 2009Publication date: October 13, 2011Applicant: PROFIBRIX B.V.Inventors: Paul Greenhalgh, Joseph Maria Grimbergen, Oliver Harvey
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Patent number: D628692Type: GrantFiled: June 23, 2009Date of Patent: December 7, 2010Assignee: Profibrix B.V.Inventor: Paul Greenhalgh
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Patent number: D683851Type: GrantFiled: June 23, 2011Date of Patent: June 4, 2013Assignee: ProFibrix B.V.Inventor: Paul Greenhalgh