Patents Assigned to Profos AG
  • Method for Detecting and for Removing Endotoxin
    Publication number: 20100028857
    Abstract: The invention relates to a method for identifying endotoxins for eliminating said endotoxins from a sample, with the aid of bacteriophage tail proteins.
    Type: Application
    Filed: July 28, 2009
    Publication date: February 4, 2010
    Applicant: PROFOS AG
    Inventors: Michael Schütz, Roman Meyer, Holger Grallert, Stefan Miller
  • Method for identifying and for extracting endotoxin
    Patent number: 7585620
    Abstract: The invention relates to a method for identifying endotoxins for eliminating said endotoxins from a sample, with the aid of bacteriophage tail proteins.
    Type: Grant
    Filed: June 24, 2003
    Date of Patent: September 8, 2009
    Assignee: Profos AG
    Inventors: Michael Schütz, Roman Meyer, Holger Grallert, Stefan Miller
  • Methods for purification of bacterial cells and components
    Patent number: 7579142
    Abstract: The present invention relates to a method for the selective purification of bacterial cells and/or cell components, whereby the purification is performed by means of a solid support.
    Type: Grant
    Filed: June 24, 2002
    Date of Patent: August 25, 2009
    Assignee: Profos AG
    Inventors: Michael Schütz, Renate Grassl, Roman Meyer, Sibylle Frick, Ingrid Robl, Thomas Zander, Stefan Miller
  • Method For Detecting And Removing Endotoxin
    Publication number: 20090017445
    Abstract: The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+ or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.
    Type: Application
    Filed: January 23, 2006
    Publication date: January 15, 2009
    Applicant: PROFOS AG
    Inventors: Stefan Miller, Roman Meyer, Renate Grassl, Manfred Biebl, Holger Graller
  • Protein
    Patent number: 7371375
    Abstract: A nucleic acid comprising a nucleotide sequence encoding a lysin, which nucleotide sequence comprises the sequence shown in SEQ ID No. 1 or a variant, homologue or derivative thereof. A novel lysin obtainable from a bacteriophage capable of colonising Clostridium perfringens, and the use thereof as a medicament for the treatment of a disorder associated with pathogenic Clostridium bacteria, for example.
    Type: Grant
    Filed: January 22, 2003
    Date of Patent: May 13, 2008
    Assignee: PROFOS AG
    Inventors: Markus Zimmer, Martin Loessner, Andrew John Morgan
  • Detection and identification of bacterial strains
    Patent number: 7087376
    Abstract: The present invention relates to a method to detect bacteria, the method comprising the following steps: coupling of the bacteriophages and/or bacteriophage proteins to a support, incubating the support coupled with the bacteriophages and/or bacteriophage proteins with a sample, optionally removing the sample and the bacteria in the sample not bound to the bacteriophages and/or bacteriophage proteins, optionally adding substances permeabilizing or destroying the bacterial membrane, and detecting the bacteria in the sample bound to the bacteriophages and/or bacteriophage proteins, wherein the bound bacteria are not subjected to a cultivation step.
    Type: Grant
    Filed: January 30, 2002
    Date of Patent: August 8, 2006
    Assignee: Profos AG
    Inventor: Stefan Miller
  • Detection and identification of bacterial strains
    Publication number: 20020127547
    Abstract: The present invention relates to a method to detect bacteria, the method comprising the following steps: coupling of the bacteriophages and/or bacteriophage proteins to a support, incubating the support coupled with the bacteriophages and/or bacteriophage proteins with a sample, optionally removing the sample and the bacteria in the sample not bound to the bacteriophages and/or bacteriophage proteins, optionally adding substances permeabilizing or destroying the bacterial membrane, and detecting the bacteria in the sample bound to the bacteriophages and/or bacteriophage proteins, wherein the bound bacteria are not subjected to a cultivation step.
    Type: Application
    Filed: January 30, 2002
    Publication date: September 12, 2002
    Applicant: PROFOS AG
    Inventor: Stefan Miller