Patents Assigned to PROFUSA, INC.
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Patent number: 11903702Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.Type: GrantFiled: September 14, 2020Date of Patent: February 20, 2024Assignee: Profusa, Inc.Inventors: Mary K. Balaconis, Scott Nichols, Sierra Guidry, Yu Zhang, Ryan Schweller, Soya Gamsey, Jacob William Clary, Sulolit Pradhan, Natalie Wisniewski
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Patent number: 11866588Abstract: The present invention is directed, in certain embodiments, to polymerizable near-IR dyes and polymers comprising said dyes as monomeric residues. In other embodiments, the present invention also relates to methods for the preparation of polymerizable near-IR dyes, and to the use of polymerizable near-IR dyes in the preparation of fluorescent polymers.Type: GrantFiled: June 21, 2019Date of Patent: January 9, 2024Assignee: Profusa, Inc.Inventors: Soya Gamsey, Alex Kutyavin, Jacob William Clary
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Publication number: 20230337951Abstract: Some embodiments described herein relate to an apparatus including a light source configured to transmit an excitation optical signal to an implanted sensor and a detector configured to detect an analyte-dependent optical signal emitted from an implanted sensor. The apparatus can include a lens configured to focus at least a portion of the analyte-dependent optical signal onto the detector.Type: ApplicationFiled: November 18, 2022Publication date: October 26, 2023Applicant: Profusa, Inc.Inventors: Gregory J. KINTZ, William A. MCMILLAN, Natalie A. WISNIEWSKI
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Publication number: 20230044094Abstract: Some embodiments described herein relate to a method that includes receiving an optical emission signal from a sensor disposed in a vessel. The vessel can be configured for an in vitro biological process (e.g., a bioreactor), and the emission signal can be received while the sensor is in contact with a biological matrix. The emission signal can be received by a reader that is disposed outside the vessel. At least one of a presence, quantity, or concentration of an analyte can be determined based on the emission signal. Similarly stated, the emission signal emitted by the sensor can be dependent on at least one of a presence, quantity, or concentration of the analyte. In some embodiments, the emission signal can be an optical signal emitted by a sensor in response to the sensor being excited by an excitation optical signal emitted by, for example, the reader.Type: ApplicationFiled: October 20, 2022Publication date: February 9, 2023Applicant: Profusa, Inc.Inventors: Ben HWANG, Soya GAMSEY
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Patent number: 11534503Abstract: Oxidase-based sensors and methods of using the sensors are provided.Type: GrantFiled: December 28, 2018Date of Patent: December 27, 2022Assignee: Profusa, Inc.Inventors: Mary K. Balaconis, Scott Nichols
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Patent number: 11504035Abstract: Some embodiments described herein relate to an apparatus including a light source configured to transmit an excitation optical signal to an implanted sensor and a detector configured to detect an analyte-dependent optical signal emitted from an implanted sensor. The apparatus can include a lens configured to focus at least a portion of the analyte-dependent optical signal onto the detector.Type: GrantFiled: March 4, 2019Date of Patent: November 22, 2022Assignee: Profusa, Inc.Inventors: Gregory J. Kintz, William A. McMillan, Natalie A. Wisniewski
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Publication number: 20220160263Abstract: An optical filter device, system, and method for improved optical rejection of out-of-band wavelengths is disclosed. For example, an analyte detection system is provided that includes an excitation light source for illuminating an implantable sensor and an optical detector for collecting emission light from the implantable sensor. Further, the analyte detection system includes an optical filter device arranged between the implantable sensor and the optical detector, wherein the optical filter device provides high optical rejection of out-of-band wavelengths of the emission light.Type: ApplicationFiled: February 11, 2022Publication date: May 26, 2022Applicant: Profusa, Inc.Inventor: Clayton LEPAK
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Patent number: 11331018Abstract: Some embodiments described herein relate to a sensor that includes an analyte-sensing dye and a reference dye. The analyte-sensing dye can be configured to emit an analyte-dependent optical signal in the presence of an analyte. Similarly stated, the intensity and/or duration of the analyte-dependent optical signal can be modulated by a quantity and/or concentration of the analyte in the environment of the sensor. The reference dye can be configured to emit an analyte-independent optical signal. The analyte-dependent optical signal and the analyte-independent optical signal have an analyte-dependent spectrum and an analyte-independent spectrum, respectfully. The analyte-dependent optical spectrum and the analyte-independent spectrum can be the same, substantially the same, and/or overlapping. The analyte-dependent optical signal can have a duration of lifetime that is shorter than a duration or lifetime of the analyte-independent optical signal.Type: GrantFiled: December 22, 2017Date of Patent: May 17, 2022Assignee: Profusa, Inc.Inventors: Brad Rice, Soya Gamsey, William A. McMillan
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Publication number: 20220095960Abstract: An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.Type: ApplicationFiled: October 4, 2021Publication date: March 31, 2022Applicant: Profusa, Inc.Inventors: Gregory J. KINTZ, William MCMILLAN, Natalie WISNIEWSKI
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Patent number: 11134871Abstract: An optical device is used to monitor an implant embedded in the tissue of a mammal (e.g., under the skin). The implant receives excitation light from the optical device and emits light that is detected by the optical device, including an analyte-dependent optical signal. Scatter and absorption properties of tissue change over time due to changes in hydration, blood perfusion and oxygenation. The optical device has an arrangement of light sources, filters and detectors to transmit excitation light within excitation wavelength ranges and to measure emitted light within detection wavelengths. Changes in scattering and absorption of light in the tissue, such as diffuse reflectance, are monitored. The light sources, filters and detectors may also be used to monitor autofluorescence in the tissue to correct autofluorescence background.Type: GrantFiled: August 13, 2018Date of Patent: October 5, 2021Assignee: Profusa, Inc.Inventors: Gregory J. Kintz, William A. McMillan, Natalie Wisniewski
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Publication number: 20210255378Abstract: An optical filter device, system, and methods for improved optical rejection of high angle of incidence (AOI) light is disclosed. For example, an analyte detection system is provided that includes an excitation light source for illuminating an implantable sensor and an optical detector for collecting emission light from the implantable sensor. Further, the optical detector portion of the analyte detection system features an optical filter device including a surface-treated microchannel wherein the surface-treated microchannel serves to absorb, trap, and/or block high-AOI light. Further, a method of operation of the presently disclosed microchannel-based optical filter device including a surface-treated microchannel is provided with respect to the high optical rejection of high-AOI light.Type: ApplicationFiled: February 19, 2021Publication date: August 19, 2021Applicant: Profusa, Inc.Inventors: Benjamin JACOBSON, Gregory KINTZ
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Publication number: 20210128035Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.Type: ApplicationFiled: September 14, 2020Publication date: May 6, 2021Applicant: Profusa, Inc.Inventors: Mary K. BALACONIS, Scott NICHOLS, Sierra GUIDRY, Yu ZHANG, Ryan SCHWELLER, Soya GAMSEY, Jacob William CLARY, Sulolit PRADHAN, Natalie WISNIEWSKI
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Publication number: 20210101915Abstract: Glucose-sensing luminescent dyes, polymers, and sensors are provided. Additionally, systems including the sensors and methods of using these sensors and systems are provided.Type: ApplicationFiled: May 26, 2020Publication date: April 8, 2021Applicant: Profusa, Inc.Inventors: Soya GAMSEY, Viachaslau BERNAT, Alex KUTYAVIN, Jacob William CLARY, Sulolit PRADHAN
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Publication number: 20210093239Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.Type: ApplicationFiled: December 8, 2020Publication date: April 1, 2021Applicant: Profusa, Inc.Inventors: Soya GAMSEY, Natalie WISNIEWSKI, Kristen HELTON, William A. MCMILLAN
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Patent number: 10874337Abstract: Oxygen sensing luminescent dyes, polymers and sensors comprising these sensors and methods of using these sensors and systems are provided.Type: GrantFiled: July 18, 2019Date of Patent: December 29, 2020Assignee: Profusa, Inc.Inventors: Soya Gamsey, Natalie Wisniewski, Kristen Helton, William A. McMillan
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Publication number: 20200305770Abstract: Tissue-integrating biosensors, systems comprising these sensors and methods of using these sensors and systems for the detection of one or more analytes are provided.Type: ApplicationFiled: November 4, 2019Publication date: October 1, 2020Applicant: Profusa, Inc.Inventors: Natalie A. WISNIEWSKI, Kristen HELTON, William A. MCMILLAN
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Patent number: 10772546Abstract: Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.Type: GrantFiled: June 29, 2018Date of Patent: September 15, 2020Assignee: Profusa, Inc.Inventors: Mary K. Balaconis, Scott Nichols, Sierra Guidry, Yu Zhang, Ryan Schweller, Soya Gamsey, Jacob William Clary, Sulolit Pradhan, Natalie Wisniewski
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Patent number: 10717751Abstract: The present disclosure provides polymerizable luminescent dyes useful for incorporation into polymers. The dyes and the polymers can be used in sensing and imaging applications, for example, to provide accurate and optionally long term measurements of glucose in vivo. The present disclosure also provides sensors including the polymers described herein. The sensors can be implanted into a tissue of a subject and used for long-term or short-term continuous and semi-continuous collection of data of various biochemical analytes, optionally without the use of implantable hardware of any type and/or enzymatic and electrochemical detection methods.Type: GrantFiled: December 27, 2017Date of Patent: July 21, 2020Assignee: Profusa, Inc.Inventors: Soya Gamsey, Viachaslau Bernat, Alex Kutyavin, Jacob William Clary, Sulolit Pradhan
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Patent number: 10662333Abstract: The invention relates to a porphyrin time domain indicator. The indicator may be used for detection of a particular analyte in vivo or in vitro. The indicator may be used for detection of glucose in vivo or in vitro.Type: GrantFiled: June 16, 2017Date of Patent: May 26, 2020Assignee: Profusa, Inc.Inventor: Arthur E. Colvin, Jr.
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Publication number: 20200140690Abstract: The present invention is directed, in certain embodiments, to polymerizable near-IR dyes and polymers comprising said dyes as monomeric residues. In other embodiments, the present invention also relates to methods for the preparation of polymerizable near-IR dyes, and to the use of polymerizable near-IR dyes in the preparation of fluorescent polymers.Type: ApplicationFiled: June 21, 2019Publication date: May 7, 2020Applicant: Profusa, Inc.Inventors: Soya GAMSEY, Alex KUTYAVIN, Jacob William CLARY