Abstract: The present invention relates to a hypertonia gene located on chromosome 12p in the genomic region between genome markers AFM338WH5 and D12S1057 and uses of such a gene.

Abstract: The present invention relates to antibodies against heart muscle actin, processes for the production of such antibodies and their use.

Abstract: The invention relates to the identification of insoluble cytoskeletal proteins, or fragments thereof, which are characteristic of the origin of the tissue. The invention relates as well to the method for detecting such proteins by breaking down and solubilizing the protein for immunological detection and quantitation. The method allows detection of tissue lesions or other pathological foci and metastases.

Abstract: In a process for the purification of cytokeratin 20 (CK 20), a cytoskeletal fraction of cells containing CK 20 is produced, the proteins present therein are separated by gel electrophoresis or/and by chromatography and the CK 20 is isolated from the gel or the chromatographic fraction containing CK 20. In a process according to the present invention for the production of antibodies specific for CK 20, purified CK 20 is used for the immunization and then polyclonal or monoclonal antibodies are produced according to well-known methods. These antibodies are used for the immunologically identification of CK 20, or its .alpha.-helical central fragment obtained by proteolytic cleavage on tissue sections, in tissue homogenates and in body fluids.