Abstract: The invention relates to novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment of a mammalian subject.
Type:
Grant
Filed:
October 16, 2008
Date of Patent:
September 9, 2014
Assignee:
Progen Pharmaceuticals Limited
Inventors:
Vito Ferro, Tomislav Karoli, Ligong Liu, Paul Newton Handley, Kenneth David Johnstone, Norbert Wimmer, Edward Timothy Hammond
Abstract: The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.
Type:
Grant
Filed:
December 3, 2010
Date of Patent:
May 8, 2012
Assignee:
Progen Pharmaceuticals Limited
Inventors:
Vito Ferro, Jon Krueger Fairweather, Tomislav Karoli, Ligong Liu
Abstract: The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.
Type:
Application
Filed:
December 3, 2010
Publication date:
June 2, 2011
Applicant:
Progen Pharmaceuticals Limited
Inventors:
Vito Ferro, Jon Krueger Fairweather, Tomislav Karoli, Ligong Liu
Abstract: The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.
Type:
Grant
Filed:
March 4, 2005
Date of Patent:
January 25, 2011
Assignee:
Progen Pharmaceuticals Limited
Inventors:
Vito Ferro, Jon Krueger Fairweather, Tomislav Karoli, Ligong Liu