Patents Assigned to Progenics, Inc.
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Patent number: 11814662Abstract: This application provides methods and compositions related to constructing nucleic acid hydrogels (e.g., RNA hydrogels) having repetitive monomer units, each monomer unit includes one or more G-quadruplex sequences. These G-quadruplex sequences cross-link the nucleic acid concatemer such that it self-assembles into a hydrogel under appropriate conditions. In some embodiments, each monomeric unit of the nucleic acid concatemer comprises a coding sequence for polypeptide of interest; and the nucleic acid hydrogel formed by the nucleic acid concatemer can be used for expressing the polypeptide in high quantities. In some embodiments, at least two RNA concatemers comprising G-quadruplex sequences are produced, one further comprising a spacer and the other further comprising a sequence encoding a polypeptide of interest. These two RNA concatemers are combined and self assembled to form a single, wideband RNA hydrogel.Type: GrantFiled: October 29, 2020Date of Patent: November 14, 2023Assignee: Progeneer, Inc.Inventors: So Yeon Ahn, Srivithya Vellampatti Krishnamoorthy, Soong Ho Um, Sung Oh, Seung Won Shin
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Publication number: 20230100429Abstract: The present invention relates to: a lyophilized preparation of a pathogen cell wall skeleton, the preparation containing the pathogen cell wall skeleton as an active ingredient; various live-pathogen-mimetic nanoparticles produced by using the lyophilized preparation and antagonists of toll-like receptor 7 or 8 which can induce the efficacy of the live pathogen; a use thereof; and a production method thereof.Type: ApplicationFiled: February 26, 2021Publication date: March 30, 2023Applicant: Progeneer Inc.Inventors: Yong Taik LIM, Sang Nam LEE
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Patent number: 11241562Abstract: Ingestible devices with a relatively large payload volume or sample volume, as well as related components, systems and methods, are disclosed.Type: GrantFiled: March 12, 2019Date of Patent: February 8, 2022Assignee: Progenity, Inc.Inventors: Mitchell Lawrence Jones, Russell B. Ford, Edward G. Solomon, Jeffrey A. Shimizu
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Patent number: 11224364Abstract: An ingestible device is disclosed which can produce spectral data of one or more analytes, as well as associated methods for characterizing the gastrointestinal tract of a subject which contains such analytes. Related kits and systems are also disclosed.Type: GrantFiled: December 15, 2017Date of Patent: January 18, 2022Assignee: Progenity, Inc.Inventors: Ryan Elliott Jones, Hamilton Roger Tang, Rachel Ellen Gerver, Mitchell Lawrence Jones
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Patent number: 11186863Abstract: Compositions and methods, systems, and kits for detecting and quantifying variations in numbers of molecules, particularly variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are normally found in diploid pairs, without digital sequencing.Type: GrantFiled: January 15, 2021Date of Patent: November 30, 2021Assignee: Progenity, Inc.Inventors: Matthew Sekedat, Jeffrey Buis, Ronald David Beaubien, Jr., Sharat Singh, Jeff Perry, Steven Lockton, Chandni Jain, Natalie Mae Jameson-Kiesling
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Patent number: 11134889Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a SMAD7 inhibitor.Type: GrantFiled: December 14, 2017Date of Patent: October 5, 2021Assignee: Progenity, Inc.Inventors: Mitchell Lawrence Jones, Sharat Singh, Christopher Loren Wahl, Harry Stylli
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Patent number: 11033490Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a JAK inhibitor.Type: GrantFiled: December 14, 2017Date of Patent: June 15, 2021Assignee: Progenity, Inc.Inventors: Mitchell Lawrence Jones, Sharat Singh, Christopher Loren Wahl, Harry Stylli
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Patent number: 11007356Abstract: An ingestible device, includes a storage reservoir configured to store a dispensable substance and a pressurized chamber configured so that, when a restraining force is removed from the pressurized chamber, the dispensable substance exits the ingestible device via openings in the ingestible device.Type: GrantFiled: September 17, 2020Date of Patent: May 18, 2021Assignee: Progenity, Inc.Inventors: Jeffrey A. Shimizu, Mitchell Lawrence Jones, Mark Sasha Drlik, Iman Niknia, Nathan John Muller, Tuyen Nguyen, Christopher Loren Wahl, Edward Mudge, Nicholas Mark Salt, Nia Eleri Stevens, Stuart Robert Abercrombie, Christopher Ian Bunce, Nelson Quintana
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Patent number: 10980739Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor.Type: GrantFiled: December 14, 2017Date of Patent: April 20, 2021Assignee: Progenity, Inc.Inventors: Mitchell Lawrence Jones, Christopher Loren Wahl, Sharat Singh, Harry Stylli, Allison Luo
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Patent number: 10947595Abstract: Methods and nucleic acid molecules for detecting chromosomal abnormalities such as aneuploidy. Methods for selecting nucleic acid molecules for use in the methods of the disclosure.Type: GrantFiled: July 30, 2020Date of Patent: March 16, 2021Assignee: Progenity, Inc.Inventors: Tobias Mann, Heng Wang, Jung H. Kim, Matthew Sekedat
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Patent number: 10835152Abstract: Various embodiments are described herein for a device, system, and method for identifying a location of an ingestible device within a gastrointestinal tract of a body. In some embodiments, the ingestible device includes a sensing unit with an axial optical sensing sub-unit located proximal to at least one end of the device, and a radial optical sensing sub-unit located proximal to a radial wall of the device, and may autonomously identify a location within the gastrointestinal tract. In some embodiments, the ingestible device includes optical illumination sources and detectors that operate at a plurality of different wavelengths, and may discern regions of a gastrointestinal tract by using the reflection properties of organ tissue and occasional particulates. In some embodiments, the ingestible device may sample fluid or release medicament based on a detected device location.Type: GrantFiled: September 25, 2015Date of Patent: November 17, 2020Assignee: Progenity, Inc.Inventors: Mitchell Lawrence Jones, Alain Labbe, Mark Sasha Drlik, Christian Terry Proch McMechan
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Publication number: 20200170937Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor.Type: ApplicationFiled: December 14, 2017Publication date: June 4, 2020Applicant: Progenity, Inc.Inventors: Mitchell Lawrence JONES, Christopher Loren WAHL, Sharat SINGH, Harry STYLLI, Allison LUO
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Patent number: 10610104Abstract: The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.Type: GrantFiled: December 7, 2017Date of Patent: April 7, 2020Assignee: Progenity, Inc.Inventors: Brian Pak, John Mitchell McLean, Paul Timothy Smith, Mitchell Lawrence Jones, Christopher Loren Wahl
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Patent number: 10588608Abstract: Sampling systems that include an absorbent material a preservative, such as an analyte preservative, as well as related materials and methods, are disclosed.Type: GrantFiled: August 18, 2017Date of Patent: March 17, 2020Assignee: Progenity, Inc.Inventors: Mitchell Lawrence Jones, Christopher Loren Wahl, Aaron Olafur Laurence Philippsen, Nicholas David Allan, Mark Sasha Drlik, Ryan Paul McGuinness, Sharat Singh, Robert S. Magyar
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Patent number: 10465245Abstract: Methods and nucleic acid molecules for detecting chromosomal abnormalities such as aneuploidy. Methods for selecting nucleic acid molecules for use in the methods of the disclosure.Type: GrantFiled: July 29, 2016Date of Patent: November 5, 2019Assignee: Progenity, Inc.Inventors: Tobias Mann, Heng Wang, Jung H. Kim, Matthew Sekedat
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Patent number: 10172598Abstract: Various embodiments are described herein for a device and method for an ingestible medical device with a rotatable element. In some described embodiments, the ingestible medical device includes a storage sub-unit with multiple chambers each having an opening for collecting or dispensing substances from the GI tract. The device further comprises a chamber enclosure with an access port. One of the chamber enclosure and the storage sub-unit are rotatable to allow for aligning the access port with a chamber opening. The ingestible medical device includes a sensor for positioning the access port of the chamber enclosure or the storage sub-unit as one of these elements rotates.Type: GrantFiled: August 15, 2014Date of Patent: January 8, 2019Assignee: Progenity, Inc.Inventors: Yaw Amoako-Tuffour, Mitchell Jones, Satya Prakash
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Publication number: 20180318496Abstract: A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).Type: ApplicationFiled: July 13, 2018Publication date: November 8, 2018Applicant: Progenity, Inc.Inventors: Hans Zou, Jeff Shimizu, Johan Frederik Dijksman
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Publication number: 20180296814Abstract: The invention relates to a method and an electronic pill (20) for administration of at least one drug (3) to a patient, wherein a delivery profile of the at least one drug is determined according to at least one individual parameter of the patient. The at least one individual parameter may particularly relate to a genotype (GEN) or phenotype of the patient and for example comprise a distribution of proteins in the patient's gastrointestinal tract (GIT). Optionally, the individual parameter may be adjusted based on measurements by the electronic pill or external devices during its passage through the patient's gastrointestinal tract.Type: ApplicationFiled: June 1, 2018Publication date: October 18, 2018Applicant: Progenity, Inc.Inventor: Jeff Shimizu
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Patent number: 10046109Abstract: A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug de delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).Type: GrantFiled: August 10, 2010Date of Patent: August 14, 2018Assignee: Progenity, Inc.Inventors: Hans Zou, Jeff Shimizu, Johan Frederik Dijksman
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Patent number: 10041106Abstract: Disclosed are methods and compositions for amplification of genetic material, including isothermal WGA of single cells.Type: GrantFiled: May 4, 2012Date of Patent: August 7, 2018Assignee: Progenity, Inc.Inventors: Haichuan Zhang, Zuxu Yao, Kerry Gunning