Patents Assigned to Progenity, Inc.
  • Patent number: 11333672
    Abstract: Disclosed herein are methods, kits, tests, and systems for detecting, predicting, monitoring, or ruling out preeclampsia in pregnant women. Also provided herein are novel diagnostic markers, methods of data analysis, assay formats, and kits employing such markers to improve one or more characteristics of a test for identifying or ruling out preeclampsia based on biomarkers from patient samples.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: May 17, 2022
    Assignee: PROGENITY, INC.
    Inventors: Matthew Cooper, Sharat Singh, Karen A. F. Copeland, Lyndal Hesterberg, Amin R. Mazloom, Mohammad Abbasi, Richard Giulio Del Mastro
  • Patent number: 11327071
    Abstract: Described herein are methods, compositions, kits, and systems for detecting free and bound PlGF, and using detection of such species to distinguish between pregnant women with or without preeclampsia or related conditions.
    Type: Grant
    Filed: August 4, 2021
    Date of Patent: May 10, 2022
    Assignee: PROGENITY, INC.
    Inventors: Pankaj Oberoi, Sharat Singh, Amin Mazloom
  • Patent number: 11241562
    Abstract: Ingestible devices with a relatively large payload volume or sample volume, as well as related components, systems and methods, are disclosed.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: February 8, 2022
    Assignee: Progenity, Inc.
    Inventors: Mitchell Lawrence Jones, Russell B. Ford, Edward G. Solomon, Jeffrey A. Shimizu
  • Patent number: 11224364
    Abstract: An ingestible device is disclosed which can produce spectral data of one or more analytes, as well as associated methods for characterizing the gastrointestinal tract of a subject which contains such analytes. Related kits and systems are also disclosed.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: January 18, 2022
    Assignee: Progenity, Inc.
    Inventors: Ryan Elliott Jones, Hamilton Roger Tang, Rachel Ellen Gerver, Mitchell Lawrence Jones
  • Patent number: 11186863
    Abstract: Compositions and methods, systems, and kits for detecting and quantifying variations in numbers of molecules, particularly variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are normally found in diploid pairs, without digital sequencing.
    Type: Grant
    Filed: January 15, 2021
    Date of Patent: November 30, 2021
    Assignee: Progenity, Inc.
    Inventors: Matthew Sekedat, Jeffrey Buis, Ronald David Beaubien, Jr., Sharat Singh, Jeff Perry, Steven Lockton, Chandni Jain, Natalie Mae Jameson-Kiesling
  • Patent number: 11134889
    Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a SMAD7 inhibitor.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: October 5, 2021
    Assignee: Progenity, Inc.
    Inventors: Mitchell Lawrence Jones, Sharat Singh, Christopher Loren Wahl, Harry Stylli
  • Patent number: 11112403
    Abstract: Described herein are methods, compositions, kits, and systems for detecting free and bound PlGF, and using detection of such species to distinguish between pregnant women with or without preeclampsia or related conditions.
    Type: Grant
    Filed: December 11, 2020
    Date of Patent: September 7, 2021
    Assignee: PROGENITY, INC.
    Inventors: Pankaj Oberoi, Sharat Singh, Amin Mazloom
  • Patent number: 11033490
    Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a JAK inhibitor.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: June 15, 2021
    Assignee: Progenity, Inc.
    Inventors: Mitchell Lawrence Jones, Sharat Singh, Christopher Loren Wahl, Harry Stylli
  • Patent number: 11007356
    Abstract: An ingestible device, includes a storage reservoir configured to store a dispensable substance and a pressurized chamber configured so that, when a restraining force is removed from the pressurized chamber, the dispensable substance exits the ingestible device via openings in the ingestible device.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: May 18, 2021
    Assignee: Progenity, Inc.
    Inventors: Jeffrey A. Shimizu, Mitchell Lawrence Jones, Mark Sasha Drlik, Iman Niknia, Nathan John Muller, Tuyen Nguyen, Christopher Loren Wahl, Edward Mudge, Nicholas Mark Salt, Nia Eleri Stevens, Stuart Robert Abercrombie, Christopher Ian Bunce, Nelson Quintana
  • Patent number: 10980739
    Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: April 20, 2021
    Assignee: Progenity, Inc.
    Inventors: Mitchell Lawrence Jones, Christopher Loren Wahl, Sharat Singh, Harry Stylli, Allison Luo
  • Patent number: 10947595
    Abstract: Methods and nucleic acid molecules for detecting chromosomal abnormalities such as aneuploidy. Methods for selecting nucleic acid molecules for use in the methods of the disclosure.
    Type: Grant
    Filed: July 30, 2020
    Date of Patent: March 16, 2021
    Assignee: Progenity, Inc.
    Inventors: Tobias Mann, Heng Wang, Jung H. Kim, Matthew Sekedat
  • Patent number: 10835152
    Abstract: Various embodiments are described herein for a device, system, and method for identifying a location of an ingestible device within a gastrointestinal tract of a body. In some embodiments, the ingestible device includes a sensing unit with an axial optical sensing sub-unit located proximal to at least one end of the device, and a radial optical sensing sub-unit located proximal to a radial wall of the device, and may autonomously identify a location within the gastrointestinal tract. In some embodiments, the ingestible device includes optical illumination sources and detectors that operate at a plurality of different wavelengths, and may discern regions of a gastrointestinal tract by using the reflection properties of organ tissue and occasional particulates. In some embodiments, the ingestible device may sample fluid or release medicament based on a detected device location.
    Type: Grant
    Filed: September 25, 2015
    Date of Patent: November 17, 2020
    Assignee: Progenity, Inc.
    Inventors: Mitchell Lawrence Jones, Alain Labbe, Mark Sasha Drlik, Christian Terry Proch McMechan
  • Publication number: 20200170937
    Abstract: This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor.
    Type: Application
    Filed: December 14, 2017
    Publication date: June 4, 2020
    Applicant: Progenity, Inc.
    Inventors: Mitchell Lawrence JONES, Christopher Loren WAHL, Sharat SINGH, Harry STYLLI, Allison LUO
  • Patent number: 10610104
    Abstract: The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.
    Type: Grant
    Filed: December 7, 2017
    Date of Patent: April 7, 2020
    Assignee: Progenity, Inc.
    Inventors: Brian Pak, John Mitchell McLean, Paul Timothy Smith, Mitchell Lawrence Jones, Christopher Loren Wahl
  • Patent number: 10588608
    Abstract: Sampling systems that include an absorbent material a preservative, such as an analyte preservative, as well as related materials and methods, are disclosed.
    Type: Grant
    Filed: August 18, 2017
    Date of Patent: March 17, 2020
    Assignee: Progenity, Inc.
    Inventors: Mitchell Lawrence Jones, Christopher Loren Wahl, Aaron Olafur Laurence Philippsen, Nicholas David Allan, Mark Sasha Drlik, Ryan Paul McGuinness, Sharat Singh, Robert S. Magyar
  • Patent number: 10465245
    Abstract: Methods and nucleic acid molecules for detecting chromosomal abnormalities such as aneuploidy. Methods for selecting nucleic acid molecules for use in the methods of the disclosure.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: November 5, 2019
    Assignee: Progenity, Inc.
    Inventors: Tobias Mann, Heng Wang, Jung H. Kim, Matthew Sekedat
  • Patent number: 10172598
    Abstract: Various embodiments are described herein for a device and method for an ingestible medical device with a rotatable element. In some described embodiments, the ingestible medical device includes a storage sub-unit with multiple chambers each having an opening for collecting or dispensing substances from the GI tract. The device further comprises a chamber enclosure with an access port. One of the chamber enclosure and the storage sub-unit are rotatable to allow for aligning the access port with a chamber opening. The ingestible medical device includes a sensor for positioning the access port of the chamber enclosure or the storage sub-unit as one of these elements rotates.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: January 8, 2019
    Assignee: Progenity, Inc.
    Inventors: Yaw Amoako-Tuffour, Mitchell Jones, Satya Prakash
  • Publication number: 20180318496
    Abstract: A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).
    Type: Application
    Filed: July 13, 2018
    Publication date: November 8, 2018
    Applicant: Progenity, Inc.
    Inventors: Hans Zou, Jeff Shimizu, Johan Frederik Dijksman
  • Publication number: 20180296814
    Abstract: The invention relates to a method and an electronic pill (20) for administration of at least one drug (3) to a patient, wherein a delivery profile of the at least one drug is determined according to at least one individual parameter of the patient. The at least one individual parameter may particularly relate to a genotype (GEN) or phenotype of the patient and for example comprise a distribution of proteins in the patient's gastrointestinal tract (GIT). Optionally, the individual parameter may be adjusted based on measurements by the electronic pill or external devices during its passage through the patient's gastrointestinal tract.
    Type: Application
    Filed: June 1, 2018
    Publication date: October 18, 2018
    Applicant: Progenity, Inc.
    Inventor: Jeff Shimizu
  • Patent number: 10046109
    Abstract: A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug de delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).
    Type: Grant
    Filed: August 10, 2010
    Date of Patent: August 14, 2018
    Assignee: Progenity, Inc.
    Inventors: Hans Zou, Jeff Shimizu, Johan Frederik Dijksman