Abstract: Apparatuses, methods, and systems for automated cell classification, embryo ranking, and/or embryo categorization are provided. An apparatus includes a classification module configured to apply classifiers to images of one or more cells to determine, for each image, a classification probability associated with each classifier. Each classifier is associated with a distinct first number of cells, and is configured to determine the classification probability for each image based on cell features including one or more machine learned cell features. The classification probability indicates an estimated likelihood that the distinct first number of cells is shown in each image. The classification module is further configured to classify each image as showing a second number of cells based on the distinct first number of cells and the classification probabilities associated therewith. The classification module is implemented in at least one of a memory or a processing device.
Type:
Grant
Filed:
September 17, 2015
Date of Patent:
July 18, 2017
Assignee:
Progyny, Inc.
Inventors:
Yu Wang, Farshid Moussavi, Peter Lorenzen, Stephen Gould
Abstract: Apparatuses, methods, and systems for automated, non-invasive evaluation of cell activity are provided. In one embodiment, an apparatus includes a hypothesis selection module configured to select a hypothesis from a plurality of hypotheses characterizing one or more cells shown in an image. Each of the plurality of hypotheses includes an inferred characteristic of the one or more cells based on geometric features of the one or more cells shown in the image. The hypothesis selection module is implemented in at least one of a memory or a processing device.
Type:
Grant
Filed:
February 28, 2014
Date of Patent:
January 10, 2017
Assignee:
PROGYNY, INC.
Inventors:
Farshid Moussavi, Yu Wang, Peter Lorenzen, Stephen Gould
Abstract: Apparatuses, methods, and systems for the automated imaging and evaluation of human embryos, oocytes, or pluripotent cells are described. An apparatus and method for automated dish detection and well occupancy determination are described. In addition, a multi-well culture dish and an illumination assembly for bimodal imaging are described. These inventions find use at least in identifying or in facilitating identification of embryos and oocytes in vitro that are most useful in treating infertility in humans.
Type:
Grant
Filed:
September 27, 2011
Date of Patent:
November 1, 2016
Assignee:
PROGYNY, INC.
Inventors:
Kevin Loewke, Lisa Young, Edward Menard, Shehua Shen, Lissa Goldenstein, Farshid Moussavi, Eugene Tucker
Abstract: Apparatuses, methods, and systems for the automated imaging and evaluation of human embryos, oocytes, or pluripotent cells are described. An apparatus and method for automated dish detection and well occupancy determination are described. In addition, a multi-well culture dish and an illumination assembly for bimodal imaging are described. These inventions find use at least in identifying or in facilitating identification of embryos and oocytes in vitro that are most useful in treating infertility in humans.
Type:
Application
Filed:
September 29, 2015
Publication date:
June 30, 2016
Applicant:
PROGYNY, INC.
Inventors:
Kevin Loewke, Lisa Young, Edward Menard, Shehua Shen, Lissa Goldenstein, Farshid Moussavi, Eugene Tucker
Abstract: Apparatuses, methods, and systems for automated cell classification, embryo ranking, and/or embryo categorization are provided. An apparatus includes a classification module configured to apply classifiers to images of one or more cells to determine, for each image, a classification probability associated with each classifier. Each classifier is associated with a distinct first number of cells, and is configured to determine the classification probability for each image based on cell features including one or more machine learned cell features. The classification probability indicates an estimated likelihood that the distinct first number of cells is shown in each image. The classification module is further configured to classify each image as showing a second number of cells based on the distinct first number of cells and the classification probabilities associated therewith. The classification module is implemented in at least one of a memory or a processing device.
Type:
Grant
Filed:
February 28, 2014
Date of Patent:
November 3, 2015
Assignee:
Progyny, Inc.
Inventors:
Yu Wang, Farshid Moussavi, Peter Lorenzen, Stephen Gould