Abstract: A heating and cooling device includes a thermoelectric module that is configured to move heat to or from a conductive surface thereof in response to low voltage power applied to the thermoelectric module. A composite structure is configured to conductively transfer heat between the thermoelectric module and the body. The composite structure includes a graphene sheet material that has an interfacing portion that is thermally coupled with and overlaying the conductive surface of the thermoelectric module. A high thermal conductivity isotropic cladding is disposed at least partially over an outlying portion of the graphene sheet material outside of the interfacing portion. The isotropic cladding conductively transfers heat in a direction orthogonal to a planar extent of the graphene sheet material with a higher thermal conductively than the graphene sheet material in this direction.