Patents Assigned to Promimic AB
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Production of nanosized calcium phosphate particles as powder or coating via bifunctional precursors
Patent number: 9975772Abstract: Method of producing calcium phosphate particles, such as hydroxyapatite particles, in the form of a powder or coating on a solid support comprising an oxide surface or a polymer surface, such as titanium, titanium alloys, stainless steel, zirconia, glass and poly(styrene), poly(ether ether ketone) (PEEK), and poly(imide) is described. The method comprises I) providing a water solution containing calcium ions and water-soluble organic compound(s) comprising at least two functional groups, II) providing another water solution containing phosphate ions and water-soluble organic compound(s) comprising at least two functional groups, followed by III) mixing the solutions of (I) and (II) to create calcium phosphate particles coated with said water-soluble organic compounds. After washing and drying, the coated particles may be used as scaffolds or for production of a powder of calcium phosphate particles or crystals.Type: GrantFiled: November 26, 2008Date of Patent: May 22, 2018Assignee: Promimic ABInventor: Per Kjellin -
Patent number: 9782435Abstract: Composites and methods of producing a mouldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.Type: GrantFiled: June 12, 2015Date of Patent: October 10, 2017Assignee: Promimic ABInventors: Per Kjellin, Paul Handa
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Patent number: 9066935Abstract: Composites and methods of producing a moldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.Type: GrantFiled: July 8, 2013Date of Patent: June 30, 2015Assignee: Promimic ABInventors: Per Kjellin, Paul Handa
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Patent number: 8632843Abstract: The invention provides methods and systems that control the application of a material onto micro-rough implant surfaces. Thus, the present invention provides method of applying crystalline nanoparticles onto the surface of an implant to produce an implant with a crystalline nanoparticle layer on its surface, the method comprising: providing an implant substrate body; applying crystalline nanoparticles onto the surface of the implant; and rotating the implant, to produce an implant with a crystalline nanoparticle layer on its surface. This method of nanoparticle application is designed to promote the integration of implants, such as dental and orthopedic screws, into living tissue, and offers the ability to control the thickness and uniformity of the nanoparticle layer, in one or several layers, while simultaneously retaining the microroughness of the implant.Type: GrantFiled: November 24, 2008Date of Patent: January 21, 2014Assignee: Promimic ABInventors: Martin Andersson, Fredrik Currie, Per Kjellin
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Patent number: 8460788Abstract: Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described.Type: GrantFiled: May 30, 2012Date of Patent: June 11, 2013Assignee: Promimic ABInventors: Per Kjellin, Martin Andersson
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Patent number: 8206813Abstract: Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described.Type: GrantFiled: June 14, 2005Date of Patent: June 26, 2012Assignee: Promimic ABInventors: Per Kjellin, Martin Andersson
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PRODUCTION OF NANOSIZED CALCIUM PHOSPHATE PARTICLES AS POWDER OR COATING VIA BIFUNCTIONAL PRECURSORS
Publication number: 20110282095Abstract: Method of producing calcium phosphate particles, such as hydroxyapatite particles, in the form of a powder or coating on a solid support comprising an oxide surface or a polymer surface, such as titanium, titanium alloys, stainless steel, zirconia, glass and poly(styrene), poly(ether ether ketone) (PEEK), and poly(imide) is described. The method comprises I) providing a water solution containing calcium ions and water-soluble organic compound(s) comprising at least two functional groups, II) providing another water solution containing phosphate ions and water-soluble organic compound(s) comprising at least two functional groups, followed by III) mixing the solutions of (I) and (II) to create calcium phosphate particles coated with said water-soluble organic compounds. After washing and drying, the coated particles may be used as scaffolds or for production of a powder of calcium phosphate particles or crystals.Type: ApplicationFiled: November 26, 2008Publication date: November 17, 2011Applicant: Promimic ABInventor: Per Kjellin -
Publication number: 20080220233Abstract: Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described.Type: ApplicationFiled: June 14, 2005Publication date: September 11, 2008Applicant: PROMIMIC ABInventors: Per Kjellin, Martin Andersson