Abstract: The present invention provides compounds that are effective against inhibiting topoisomerase (i.e., topoisomerase I and/or topoisomerase II). These compounds are used for treating cell-proliferative disorders. In some instances, these compounds have anticancer activity, e.g., against multi-drug resistant cancers.
Type:
Grant
Filed:
May 25, 2005
Date of Patent:
March 23, 2010
Assignee:
Propharmacon Inc.
Inventors:
Martin A. Murphy, John Robert Schullek, John S. Ward, Gary C. Look, Brian Siesel