Abstract: The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat a pathology of the muscle or heart, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the muscle cells or heart cells.
Type:
Grant
Filed:
August 7, 2012
Date of Patent:
August 27, 2013
Assignee:
Prosena Technologies B.V.
Inventors:
Johannes Antonius Heemskerk, Judith Christina Theodora Van Deutekom, Petra Van Kuik-Romeijn, Gerard Johannes Platenburg