Patents Assigned to Prosensa Technologies B.V.
-
Patent number: 9139828Abstract: The invention relates to oligonucleotides that bind to and induce skipping of exon 44 in the human dystrophin pre-mRNA, and methods of use.Type: GrantFiled: November 11, 2010Date of Patent: September 22, 2015Assignees: Prosensa Technologies B.V., Academisch Ziekenhuis LeidenInventors: Gerard Johannes Platenburg, Josephus Johannes de Kimpe, Judith Christina Theodora van Deutekom, Garrit-Jan Boudewijn van Ommen, Annemieke Aartsma-Rus
-
Patent number: 8802645Abstract: The invention provides two types of oligonucleotides for treating an inflammatory disorder: an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a C5 in order to decrease the amount of a C5a and an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a IL-1RAcP in order to increase the amount of a soluble IL-1RAcP. The invention further provides the use of said oligonucleotides for preventing or treating an inflammatory disorder.Type: GrantFiled: June 21, 2012Date of Patent: August 12, 2014Assignees: Prosensa Technologies B.V., Academisch Ziekenhuis Leiden H.O.D.N. LUMCInventors: Garrit-Jan Boudewijn Van Ommen, Annemieke Aartsma-Rus, Judith Christina Theodora Van Deutekom, Josephus Johannes De Kimpe, Joseph Stephan Verbeek, Aliye Seda Ylmaz-Elis
-
Publication number: 20140221458Abstract: The invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing an isolate muscle cell with a molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such molecule used in the method.Type: ApplicationFiled: March 7, 2014Publication date: August 7, 2014Applicants: Prosensa Technologies B.V., Academisch Ziekenhuis Leiden, Prosensa Holding B.V., Prosensa B.V.Inventors: Josephus Johannes De Kimpe, Annemieke Aartsma-Rus, Gerard Johannes Platenburg, Judith Christina Theodora Van Deutekom, Garrit-Jan Boudewijn Van Ommen
-
Publication number: 20140128592Abstract: The invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing an isolate muscle cell with a molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such molecule used in the method.Type: ApplicationFiled: December 19, 2013Publication date: May 8, 2014Applicants: Prosensa Technologies B.V., Academisch Ziekenhuis Leiden, Prosensa Holding B.V., Prosensa B.V.Inventors: Josephus Johannes De Kimpe, Annemieke Aartsma-Rus, Gerard Johannes Platenburg, Judith Christina Theodora Van Deutekom, Garrit-Jan Boudewijn Van Ommen
-
Publication number: 20140113955Abstract: The invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing an isolate muscle cell with a molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such molecule used in the method.Type: ApplicationFiled: December 4, 2013Publication date: April 24, 2014Applicants: Prosensa Technologies B.V., Academisch Ziekenhuis Leiden, Prosensa Holding B.V., Prosensa B.V.Inventors: Josephus Johannes De Kimpe, Annemieke Aartsma-Rus, Gerard Johannes Platenburg, Judith Christina Theodora Van Deutekom, Garrit-Jan Boudewijn Van Ommen
-
Publication number: 20140045763Abstract: The current invention provides new compounds for treating, delaying and/or preventing a human genetic disorder such as myotonic dystrophy type 1 (DM1), spino-cerebellar ataxia 8 and/or Huntington's disease-like 2 caused by expansions of CUG repeats in the transcripts of DM1/DMPK, SCA8 or JPH3 genes.Type: ApplicationFiled: October 17, 2013Publication date: February 13, 2014Applicant: PROSENSA TECHNOLOGIES B.V.Inventors: Maria BegoƱa Aguilera Diez, Peter Christian de Visser, Susan Allegonda Maria Mulders
-
Patent number: 8609065Abstract: The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat neuronal or neuromuscular disease, or a pathology of the brain, or a tumor of neuronal or neuroectodermal origin, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the brain cells or neuronal cells, or by the tumor cells of neuronal or neuroectodermal origin. The invention also provides a method of identifying and measuring neurite growth in neuronal cells.Type: GrantFiled: January 8, 2010Date of Patent: December 17, 2013Assignee: Prosensa Technologies B.V.Inventors: Petra Van Kuik-Romeijn, Gerard Johannes Platenburg
-
Publication number: 20120322724Abstract: The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat a pathology of the muscle or heart, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the muscle cells or heart cells.Type: ApplicationFiled: August 7, 2012Publication date: December 20, 2012Applicant: Prosensa Technologies B.V.Inventors: Johannes Antonius Heemskerk, Judith Christina Theodora Van Deutekom, Petra Van Kuik-Romeijn, Gerard Johannes Platenburg
-
Publication number: 20120259002Abstract: The invention provides two types of oligonucleotides for treating an inflammatory disorder: an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a C5 in order to decrease the amount of a C5a and an oligonucleotide which is able of altering the splicing of a pre-mRNA encoding a IL-1RAcP in order to increase the amount of a soluble IL-1RAcP. The invention further provides the use of said oligonucleotides for preventing or treating an inflammatory disorder.Type: ApplicationFiled: June 21, 2012Publication date: October 11, 2012Applicants: Acedemisch Ziekenhuis Leiden h.o.d.n. LUMC, Prosensa Technologies B.V.Inventors: Garrit-Jan Boudewijn Van Ommen, Annemieke Aartsma-Rus, Judith Christina Theodora Van Deutekom, Josephus Johannes De Kimpe, Joseph Stephan Verbeek, Aliye Seda Ylmaz-Elis
-
Patent number: 8268962Abstract: The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat a pathology of the muscle or heart, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the muscle cells or heart cells.Type: GrantFiled: January 11, 2010Date of Patent: September 18, 2012Assignee: Prosensa Technologies B.V.Inventors: Johannes Antonius Heemskerk, Judith Christina Theodora Van Deutekom, Petra Van Kuik-Romeijn, Gerard Johannes Platenburg
-
Publication number: 20120059042Abstract: The invention relates to a nucleic acid molecule that binds and/or is complementary to the nucleotide molecule having sequence 5?-GUGGCUAACAGAAGCU (SEQ ID NO 1) and to its use in a method for inducing skipping of exon 44 of the DMD gene in a DMD patient.Type: ApplicationFiled: November 11, 2010Publication date: March 8, 2012Applicants: PROSENSA TECHNOLOGIES B.V., ACADEMISCH ZIEKENHUIS LEIDENInventors: Gerard Johannes Platenburg, Josephus Johannes de Kimpe, Judith Christina Theodora van Deutekom, Garrit-Jan Boudewijn van Ommen, Annemieke Aartsma-Rus
-
Publication number: 20120046342Abstract: The invention provides an oligonucleotide comprising an inosine, and/or a nucleotide containing a base able to form a wobble base pair or a functional equivalent thereof, wherein the oligonucleotide, or a functional equivalent thereof, comprises a sequence which is complementary to at least part of a dystrophin pre-m RNA exon or at least part of a non-exon region of a dystrophin pre-m RNA said part being a contiguous stretch comprising at least 8 nucleotides. The invention further provides the use of said oligonucleotide for preventing or treating DMD or BMD.Type: ApplicationFiled: April 26, 2010Publication date: February 23, 2012Applicant: Prosensa Technologies B.V.Inventors: Judith Christina Theodora Van Deutekom, Josephus Johannes De Kimpe, Gerardus Johannes Platenburg
-
Publication number: 20120022134Abstract: The invention relates to a method for inducing or promoting skipping of exon 45 of DMD pre-mRNA in a Duchenne Muscular Dystrophy patient, preferably in an isolated (muscle) cell, the method comprising providing said cell with a molecule that binds to a continuous stretch of at least 21 nucleotides within said exon. The invention further relates to such molecule used in said method.Type: ApplicationFiled: April 26, 2011Publication date: January 26, 2012Applicants: PROSENSA TECHNOLOGIES B.V., ACADEMISCH ZIEKENHUIS LEIDEN, PROSENSA HOLDING BV, PROSENSA B.V.Inventors: JOSEPHUS JOHANNES DE KIMPE, GERARDUS JOHANNES PLATENBURG, JUDITH CHRISTINA THEODORA VAN DEUTEKOM, ANNEMIEKE AARTSMA-RUS, GARRIT-JAN BOUDEWIJN VAN OMMEN
-
Publication number: 20110294753Abstract: The invention provides means and methods for alleviating one or more symptom(s) of Duchenne Muscular Dystrophy and/or Becker Muscular Dystrophy. Therapies using compounds for providing patients with functional muscle proteins are combined with at least one adjunct compound for reducing inflammation, preferably for reducing muscle tissue inflammation, and/or at least one adjunct compound for improving muscle fiber function, integrity and/or survival.Type: ApplicationFiled: April 26, 2010Publication date: December 1, 2011Applicants: Prosensa Technologies B.V., Academisch Ziekenhuis LeidenInventors: Josephus Johannes De Kimpe, Gerard Johannes Platenburg, Judith Christina Theodora Van Deutekom, Annemieke Aartsma-Rus, Garrit-Jan Boudewijn Van Ommen
-
Publication number: 20110263682Abstract: The invention relates a method wherein a molecule is used for inducing and/or promoting skipping of at least one of exon 43, exon 46, exons 50-53 of the DMD pre-mRNA in a patient, preferably in an isolated cell of a patient, the method comprising providing said cell and/or said patient with a molecule. The invention also relates to said molecule as such.Type: ApplicationFiled: April 26, 2011Publication date: October 27, 2011Applicants: Academisch Ziekenhuis Leiden, Prosensa Holding BV, Prosensa Technologies B.V., Prosensa B.V.Inventors: Josephus Johannes De Kimpe, Gerardus Johannes Platenburg, Judith Christina Theodora Van Deutekom, Annemieke Aartsma-Rus, Garrit-Jan Boudewijn Van Ommen
-
Publication number: 20100184947Abstract: The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat neuronal or neuromuscular disease, or a pathology of the brain, or a tumor of neuronal or neuroectodermal origin, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the brain cells or neuronal cells, or by the tumor cells of neuronal or neuroectodermal origin. The invention also provides a method of identifying and measuring neurite growth in neuronal cells.Type: ApplicationFiled: January 8, 2010Publication date: July 22, 2010Applicant: Prosensa Technologies B.V.Inventors: Petra Van Kuik-Romeijn, Gerard Johannes Platenburg
-
Publication number: 20100184948Abstract: The invention provides conjugates, comprising an organ, tissue or tumor cell homing molecule linked to a moiety. Such a moiety can be, for example, an oligonucleotide, small interfering RNA, gene, virus, protein, pharmaceutical or detectable agent. In addition the invention provides methods to diagnose or treat a pathology of the muscle or heart, by administrating to a subject having or suspected of having a pathology a molecule or conjugate that homes to, binds to and is taken up by the muscle cells or heart cells.Type: ApplicationFiled: January 11, 2010Publication date: July 22, 2010Applicant: PROSENSA TECHNOLOGIES B.V.Inventors: JOHANNES ANTONIUS HEEMSKERK, JUDITH CHRISTINA THEODORA VAN DEUTEKOM, PETRA VAN KUIK-ROMEIJN, GERARD JOHANNES PLATENBURG
-
Publication number: 20090318403Abstract: The present invention provides antimicrobial compositions comprising an antibiotic and a sensitizer that enhances the effectiveness or activity of the antibiotic, wherein the sensitizer is preferably a primary amine containing a long alkyl chain. Such compositions are particularly useful for the treatment of infections by drug resistant bacteria.Type: ApplicationFiled: August 2, 2007Publication date: December 24, 2009Applicant: Prosensa Technologies B.V.Inventors: Peter Christian De Visser, Gerard Johannes Platenburg, Jaap Tamino Van Dissel