Patents Assigned to PROSONIX LIMITED
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Patent number: 9682038Abstract: Pharmaceutical compositions comprising multi-component crystalline particles suitable for use in inhalation therapy and for delivery by oral or nasal inhalation are provided, wherein said compositions additionally comprise particles of at least one additional active agent. Also provided are methods of preparation of the compositions and their use in medicine.Type: GrantFiled: January 29, 2014Date of Patent: June 20, 2017Assignee: Prosonix LimitedInventors: John Burns, Dipesh Parikh
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Patent number: 9637840Abstract: This invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising contacting said solid material with solvent in which the solid material is insoluble or poorly soluble (a non-solvent); and applying ultrasound to the solid material when in contact with said non-solvent.Type: GrantFiled: July 20, 2009Date of Patent: May 2, 2017Assignee: Prosonix LimitedInventors: Graham Ruecroft, Dipesh Parikh, David Hipkiss
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Patent number: 9278323Abstract: A process for preparing an emulsion or a dispersion comprising crystalline particles of at least one active principal that comprises contacting a solution of at least one solute in a solvent or mixture of solvents in a first flowing stream with a non-solvent in a second flowing stream wherein the non-solvent and solvent are not miscible with each other, so as to form an emulsion or a dispersion. Super saturation is brought about by suitable means, and the emulsion or dispersion is subjected to ultrasonic irradiation to mediate crystal nucleation.Type: GrantFiled: June 17, 2008Date of Patent: March 8, 2016Assignee: Prosonix LimitedInventors: Graham Ruecroft, James Robinson, Dipesh Parikh
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Publication number: 20160001252Abstract: A process for preparing crystalline particles of an active principal in the presence of ultrasonic irradiation that comprises contacting a solution of a solute in a solvent in a first flowing stream with an anti-solvent in a second flowing stream causing the mixing thereof, wherein the flow rate ratio of the anti-solvent: solvent is higher than 20:1, and collecting crystals that are generated.Type: ApplicationFiled: September 15, 2015Publication date: January 7, 2016Applicant: PROSONIX LIMITEDInventors: James Robinson, Graham Ruecroft
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Patent number: 9220708Abstract: This invention provides a pharmaceutical composition comprising a eutectic composition of two pharmacologically active ingredients for delivery to the lung by inhalation. This invention also provides a pharmaceutical composition comprising a eutectic composition of two pharmacologically active ingredients for the treatment of respiratory disease.Type: GrantFiled: August 8, 2012Date of Patent: December 29, 2015Assignee: Prosonix LimitedInventors: Graham Ruecroft, Dipesh Parikh
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Publication number: 20150366804Abstract: Pharmaceutical compositions comprising multi-component crystalline particles suitable for use in inhalation therapy and for delivery by oral or nasal inhalation are provided, wherein said compositions additionally comprise particles of at least one additional active agent. Also provided are methods of preparation of the compositions and their use in medicine.Type: ApplicationFiled: January 29, 2014Publication date: December 24, 2015Applicant: Prosonix LimitedInventors: John Burns, Dipesh Parikh
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Publication number: 20150352077Abstract: Pharmaceutical Preparations Multi-component crystalline particles and compositions, methods for their preparation, their uses in inhalation therapy and inhaler devices containing said particles are provided, in particular particles comprising glycopyrrolate. The particles can be prepared substantially free of excipients and agents other than active agents or their precursors in the presence of ultrasonic irradiation in a process comprising contacting a solution in a first flowing stream with an anti-solvent in a re-circulating second flowing stream, causing the mixing thereof and collecting crystals that are generated.Type: ApplicationFiled: January 29, 2014Publication date: December 10, 2015Applicant: Prosonix LimitedInventors: John Burns, Dipesh Parikh, Shyam Karki
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Patent number: 9162160Abstract: A process for preparing crystalline particles of an active principal in the presence of ultrasonic irradiation that comprises contacting a solution of a solute in a solvent in a first flowing stream with an anti-solvent in a second flowing stream causing the mixing thereof, wherein the flow rate ratio of the anti-solvent: solvent is higher than 20:1, and collecting crystals that are generated.Type: GrantFiled: March 18, 2008Date of Patent: October 20, 2015Assignee: Prosonix LimitedInventors: James Robinson, Graham Ruecroft
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Patent number: 8771744Abstract: The invention provides a process for increasing the crystallinity of at least one solid material which is less than 100% crystalline, comprising applying ultrasound to the substantially dry solid material.Type: GrantFiled: October 20, 2010Date of Patent: July 8, 2014Assignee: Prosonix LimitedInventors: Graham Ruecroft, Dipesh Parikh
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Publication number: 20110288060Abstract: This invention provides an oscillating baffled reactor apparatus for preparing crystalline particles of at least one substance comprising: a reactor vessel; means for supplying a first flowing stream; means for oscillating fluid within the reactor vessel; a plurality of baffles; source of ultrasonic radiation; and means for collecting said particles.Type: ApplicationFiled: January 5, 2010Publication date: November 24, 2011Applicant: PROSONIX LIMITEDInventors: Graham Ruecroft, John Burns
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Publication number: 20100190760Abstract: A process for preparing an emulsion or a dispersion comprising crystalline particles of at least one active principal that comprises contacting a solution of at least one solute in a solvent or mixture of solvents in a first flowing stream with a non-solvent in a second flowing stream wherein the non-solvent and solvent are not miscible with each other, so as to form an emulsion or a dispersion. Super saturation is brought about by suitable means, and the emulsion or dispersion is subjected to ultrasonic irradiation to mediate crystal nucleation.Type: ApplicationFiled: June 17, 2008Publication date: July 29, 2010Applicant: PROSONIX LIMITEDInventors: Graham Ruecroft, James Robinson, Dipesh Parikh
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Publication number: 20100018853Abstract: A process for preparing crystalline particles of an active principal in the presence of ultrasonic irradiation that comprises contacting a solution of a solute in a solvent in a first flowing stream with an anti-solvent in a second flowing stream causing the mixing thereof, wherein the flow rate ratio of the anti-solvent: solvent is higher than 20:1, and collecting crystals that are generated.Type: ApplicationFiled: March 18, 2008Publication date: January 28, 2010Applicant: PROSONIX LIMITEDInventors: James Robinson, Graham Ruecroft