Patents Assigned to Prospa B.V.
  • Patent number: 6121244
    Abstract: The use of some semisynthetic derivatives of the antifungal polyene partricin to selectively hinder the growth of tumor cells is here described. Their use can be associated with the use of other known antineoplastic agents, in particular in the cases where a resistance to these agents is present or has developed.The invention can be applied to systems of cell cultures as well as to the therapeutic practice.
    Type: Grant
    Filed: February 26, 1999
    Date of Patent: September 19, 2000
    Assignee: Prospa B.V.
    Inventor: Tiberio Bruzzese
  • Patent number: 5914321
    Abstract: The use of some semisynthetic derivatives of the antifungal polyene partricin to selectively hinder the growth of tumor cells is here described.Their use can be associated with the use of other known antineoplastic agents, in particular in the cases where a resistance to these agents is present or has developed.The invention can be applied to systems of cell cultures as well as to the therapeutic practice.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: June 22, 1999
    Assignee: Prospa B.V.
    Inventor: Tiberio Bruzzese
  • Patent number: 5908834
    Abstract: The use of ester and/or amide derivatives of partricin A and/or B to inhibit or forestall the growth of yeasts and molds in cell cultures of animal or vegetable origin, including hybridomas and cells whose DNA was modified. This use consists in adding the afore-said derivatives to the cell cultures in concentrations such as to inhibit the growth of yeast and molds but such as not to be toxic for the cell cultures themselves. The invention can be made use of, for instance, in the production of vaccines and in the conservation of organs and tissues intended for transplantation.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: June 1, 1999
    Assignee: Prospa B.V.
    Inventor: Tiberio Bruzzese
  • Patent number: 5869714
    Abstract: Salts of formula RCOOR'R".sub.2 N.sup.+ (CH.sub.2).sub.n OH wherein R represents the alkenyl radical of a C.sub.20 -C.sub.22 omega-3-polyunsaturated acid; R' represents a hydrogen atom or a C.sub.1 -C.sub.2 alkyl radical; R" represents R', as above defined, or (CH.sub.2).sub.n OH hydroxyalkyl radical where n is 2 or 3; and their use as cardiovascular agents.
    Type: Grant
    Filed: June 11, 1997
    Date of Patent: February 9, 1999
    Assignee: Prospa B.V.
    Inventor: Tiberio Bruzzese
  • Patent number: 5776978
    Abstract: Pharmaceutical preparations are described, useful in the prevention and/or treatment of atherosclerosis, of cardiovascular, nervous system, skin and malignant pathologies, containing 50 to 1000 mg of omega-3 fatty acids, their esters and their salts with inorganic and organic bases, as individual compounds or as a mixture, in combination with 10-40% by weight of antioxidant/reducing vitamins or provitamins.
    Type: Grant
    Filed: August 22, 1995
    Date of Patent: July 7, 1998
    Assignee: Prospa B.V.
    Inventor: Tiberio Bruzzese
  • Patent number: 5750572
    Abstract: 4,7,10,13,16,19-cis-Docosahexaenoic acid (DHA) salts with basic amino acids, in particular arginine and lysine, have favorable therapeutic and technological characteristics compared with the acid.
    Type: Grant
    Filed: July 5, 1996
    Date of Patent: May 12, 1998
    Assignee: Prospa B.V.
    Inventor: Tiberio Bruzzese
  • Patent number: 5736565
    Abstract: The present invention is referred to sulphur-acylated derivatives of L-pyroglutamyl-L-cysteine of formula (I) ##STR1## where R is a linear or branched alkyl containing 1 to 6 carbon atoms, their pharmaceutically acceptable salts, the process for their preparation, and the pharmaceutical compositions containing same. Said derivatives are suitable for the treatment of diseases connected with glutathione deficiency.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: April 7, 1998
    Assignee: Prospa B.V.
    Inventor: Lorenzo Ferrari
  • Patent number: 5472705
    Abstract: New pharmaceutical compositions for topical use containing esters of .omega.-3 polyunsaturated acids having a high concentration have been obtained. Such formulations have been added with phenolic antioxidants and with adjuvants.The present formulations have been found clinically useful in the treatment of morbid affections, in particular in the treatment of psoriasis, phlebitis and the correlated pathologies.
    Type: Grant
    Filed: July 23, 1993
    Date of Patent: December 5, 1995
    Assignee: Prospa B.V.
    Inventors: Tiberio Bruzzese, Giovanni Mozzi, Remo Ruggeri