Abstract: The present invention provides a method for ameliorating or treating inflammatory bowel disease (IBD) and/or irritable bowel syndrome (IBS), comprising administering extracellular vesicles derived from Kefir grains in a mammal in need thereof. The present invention also provides a pharmaceutical composition for ameliorating or treating IBD and/or IBS or a functional food composition for ameliorating or improving IBD and/or IBS, comprising said extracellular vesicles derived from Kefir grains as an active ingredient.
Type:
Grant
Filed:
May 23, 2019
Date of Patent:
April 28, 2020
Assignee:
PROSTEMICS CO. LTD.
Inventors:
Eun-Joo Park, Min-Koo Seo, Seong-Yeol Ko, Eun-Wook Choi, Won-Jong Lee
Abstract: The present invention relates to a method for producing large amounts of human growth factors from human adipose-derived stem cells. More specifically, the invention provides a method capable of synthesizing human growth factors in significantly large amounts by culturing adipose-derived stem cells extracted from human adipose cells in suitable media and conditions. Also, stem cell culture media produced according to the method of the invention, and human growth factors isolated from the culture media, can be advantageously used as raw materials for drugs and cosmetics.
Type:
Grant
Filed:
October 12, 2006
Date of Patent:
August 18, 2015
Assignees:
PROSTEMICS CO., LTD.
Inventors:
ByungSoon Park, BongGeun Choi, ChulHong Park
Abstract: Provided is a preparation method of a porous hyaluronic acid sponge comprising the steps of: dissolving hyaluronic acid in an aqueous sodium hydroxide solution; adding an epoxy-based crosslinking agent to the resultant aqueous sodium hydroxide solution in which hyaluronic acid is dissolved and homogenizing the hyaluronic acid solution; hydrogelating the homogenized hyaluronic acid solution; washing the hydrogelated hyaluronic acid hydrogel with ultrapure water; swelling the washed hyaluronic acid hydrogel to attain porosity; and freeze-drying the hyaluronic acid hydrogel to obtain a porous hyaluronic acid sponge.
Type:
Grant
Filed:
May 2, 2007
Date of Patent:
June 5, 2012
Assignees:
Seoul National University Industry Foundation, Prostemics Co., Ltd.
Inventors:
Dae-Duk Kim, Jeong-Yeon Kang, Chung-Wook Chung, In-Soo Yoon, Sun-Young Kim, Byung-Soon Park, Jong-Hyuk Sung
Abstract: The present invention relates to a method for producing large amounts of human growth factors from human adipose-derived stem cells. More specifically, the invention provides a method capable of synthesizing human growth factors in significantly large amounts by culturing adipose-derived stem cells extracted from human adipose cells in suitable media and conditions. Also, stem cell culture media produced according to the method of the invention, and human growth factors isolated from the culture media, can be advantageously used as raw materials for drugs and cosmetics.
Type:
Application
Filed:
September 7, 2011
Publication date:
March 15, 2012
Applicants:
PROSTEMICS CO., LTD.
Inventors:
ByungSoon Park, BongGeun Choi, ChulHong Park
Abstract: The present invention provides a pharmaceutical composition for treating cancer, comprising a culture of adult stem cells or a fraction of the culture as an active ingredient. The culture of adult stem cells and its fraction, especially a specific fraction of adult stem cell culture, inhibit proliferation of a variety of cancer such as melanoma, pancreatic cancer, breast cancer, hepatic cancer, gastric cancer, colon cancer, lung cancer, and cervical cancer, thereby having excellent cancer-treating activity. The composition according to the present invention includes, not stem cells, but a complex of active proteins secreted from the stem cells, and thus both pharmaceutical problems in formulation and individual variation, which usually occurred when using stem cells, can be minimized. And also, side effects caused by direct administration of cells into the human bodies can be thoroughly prevented.
Type:
Application
Filed:
May 14, 2009
Publication date:
November 26, 2009
Applicant:
PROSTEMICS CO., LTD.
Inventors:
Byung-Soon Park, Won-Serk Kim, Jong-Hyuk Sung
Abstract: The present invention provides a whitening cosmetic composition comprising a stem cell, a culture medium thereof or a protein isolated from the culture medium and a method of whitening a skin which comprises administering to the skin an therapeutically effective amount of a stem cell, a culture medium thereof or a protein isolated from the culture medium.
Type:
Application
Filed:
July 28, 2008
Publication date:
February 5, 2009
Applicant:
PROSTEMICS CO., LTD.
Inventors:
ByungSoon Park, WonSerk Kim, Jong-Hyuk Sung, SeJin Ahn
Abstract: The present invention relates to a method for producing large amounts of human growth factors from human adipose-derived stem cells. More specifically, the invention provides a method capable of synthesizing human growth factors in significantly large amounts by culturing adipose-derived stem cells extracted from human adipose cells in suitable media and conditions. Also, stem cell culture media produced according to the method of the invention, and human growth factors isolated from the culture media, can be advantageously used as raw materials for drugs and cosmetics.
Type:
Application
Filed:
October 12, 2006
Publication date:
January 1, 2009
Applicants:
PROSTEMICS CO., LTD.
Inventors:
ByungSoon Park, BongGeun Choi, ChulHong Park